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htrA htrA isp isp flgB flgB flgC flgC fliE fliE fliG fliG fliF fliF fliH fliH fliI fliI fliK fliK flgD flgD flgE flgE fliM fliM fliP fliP fliQ fliQ fliR fliR flhB flhB flhA flhA ymfF ymfF ymfH ymfH aprX aprX eglS eglS phy phy sacC sacC phoR phoR phoP phoP yugT yugT htrB htrB levB levB fliT fliT fliS fliS fliD fliD flgL flgL flgK flgK rbsB rbsB ywhC ywhC sacA sacA vpr vpr epr epr bglS bglS htrC htrC ftsH ftsH phoD phoD malA malA phoA phoA yhfN yhfN phoE phoE
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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htrAMembrane bound serine protease Do, quality control protease (heat-shock protein); Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth (Probable); Belongs to the peptidase S1C family. (449 aa)
ispIntracellular serine protease; Major intracellular protease produced by Bacillus subtilis. (319 aa)
flgBFlagellar component of cell-proximal portion of basal-body rod; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (129 aa)
flgCFlagellar component of cell-proximal portion of basal-body rod; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type s: structure; Belongs to the flagella basal body rod proteins family. (150 aa)
fliEFlagellar basal body protein; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type s: structure. (106 aa)
fliGFlagellar motor switching and energizing component; One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation; Belongs to the FliG family. (338 aa)
fliFFlagellar basal-body M-ring protein; The M ring may be actively involved in energy transduction. (536 aa)
fliHFlagellar export apparatus component; Needed for flagellar regrowth and assembly. (208 aa)
fliIFlagellar-specific ATPase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. (438 aa)
fliKFlagellar hook-length control protein; Controls the length of the flagellar hook. (487 aa)
flgDFlagellar hook assembly protein; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type pf: putative factor; Belongs to the FlgD family. (140 aa)
flgEFlagellar hook protein; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type f: factor; Belongs to the flagella basal body rod proteins family. (264 aa)
fliMFlagellar motor switching and energizing component; One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation; Belongs to the FliM family. (332 aa)
fliPComponent of the flagellar export machinery; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (221 aa)
fliQComponent of the flagellar export machinery; Role in flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRComponent of the flagellar export machinery; Role in flagellar biosynthesis; Belongs to the FliR/MopE/SpaR family. (259 aa)
flhBComponent of the flagellar export machinery; May be involved in the export of flagellum proteins; Belongs to the type III secretion exporter family. (360 aa)
flhAComponent of the flagellar export machinery; Involved in the export of flagellum proteins. (677 aa)
ymfFPutative metalloprotease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase M16 family. (426 aa)
ymfHPutative processing protease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme. (428 aa)
aprXAlkaline serine protease; Displays serine protease activity. Seems to have a broad substrate specificity. (442 aa)
eglSEndo-1,4-beta-glucanase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (499 aa)
phyPhytase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme. (382 aa)
sacCLevanase; Exo-fructosidase that can hydrolyze both levan and inulin, leading to the production of free fructose. Is also able to hydrolyze sucrose and to a small extent raffinose, but not melezitose, stachylose, cellobiose, maltose, and lactose. (677 aa)
phoRTwo-component sensor histidine kinase; Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. (579 aa)
phoPTwo-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. (240 aa)
yugTPutative oligo-1,6-glucosidase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 13 family. (554 aa)
htrBHtrA-like serine protease; Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth (Probable); Belongs to the peptidase S1C family. (458 aa)
levBEndolevanase; Catalyzes the degradation of levan mainly into levanbiose (difructose). Is not active on sucrose; Belongs to the glycosyl hydrolase 32 family. (516 aa)
fliTFlagellar assembly protein FliT involved in control of flagella expression; May act as an export chaperone for the filament capping protein FliD; Belongs to the bacillales FliT family. (113 aa)
fliSFlagellar assembly protein FliS; Essential for filament assembly. May act as a facilitator of flagellin (hag) secretion. Antagonizes translational repressor CsrA indirectly. Belongs to the FliS family. (133 aa)
fliDFlagellar hook-associated capping protein 2 (HAP2); Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity); Belongs to the FliD family. (498 aa)
flgLFlagellar hook-filament junction; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; structure. (298 aa)
flgKFlagellar hook-filament junction; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; structure. (507 aa)
rbsBRibose ABC transporter (ribose-binding lipoprotein); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. (305 aa)
ywhCPutative metal-dependent hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase M50B family. (219 aa)
sacASucrase-6-phosphate hydrolase; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme; Belongs to the glycosyl hydrolase 32 family. (479 aa)
vprExtracellular serine protease; Not required for growth or sporulation. (806 aa)
eprExtracellular serine protease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the peptidase S8 family. (645 aa)
bglSEndo-beta-1,3-1,4 glucanase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 16 family. (242 aa)
htrCPutative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. (400 aa)
ftsHCell-division protein and general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (637 aa)
phoDAlkaline phosphatase D; Evidence 1a: Function experimentally demonstrated in the studied strain; enzyme. (583 aa)
malA6-phospho-alpha-glucosidase; Hydrolyzes maltose-6'-phosphate and trehalose-6'-phosphate. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP- PTS). Is also able to significantly catalyze the hydrolysis of both 6- phospho-alpha- and 6-phospho-beta-glucosides containing activated leaving groups such as p-nitrophenol and does so with retention and inversion, respectively, of the substrate anomeric configuration. (449 aa)
phoAAlkaline phosphatase A; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. (461 aa)
yhfNPutative membrane metalloprotease; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (426 aa)
phoEPhosphatase; Phosphatase with broad substrate specificity. Does not have phosphoglycerate mutase activity; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (193 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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