STRINGSTRING
tig tig wapA wapA efeN efeN vpr vpr trxB trxB yvgO yvgO asnB asnB rpsD rpsD araB araB lepA lepA dnaK dnaK ansA ansA pelB pelB oppA oppA phoA phoA groEL groEL groES groES amyE amyE ansZ ansZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tigProlyl isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily. (424 aa)
wapACell wall-associated protein precursor; Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. A site-specific general tRNA nuclease, the C-terminus (residues 2201-2334) removes 2 or 4 nucleotides from the 3' end of at least 4 tRNAs (upon expression in E.coli), possibly endonucleolytically. The nuclease activity is neutralized by expression of the cognate immunity protein WapI from the same strain, but not its homolog from 2 other B.subtilis strains. The C-terminus cannot be expressed on its own in E.coli, how [...] (2334 aa)
efeNPeroxidase converting ferric iron into ferrous iron; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact (By similarity). (416 aa)
vprExtracellular serine protease; Not required for growth or sporulation. (806 aa)
trxBThioredoxin reductase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (316 aa)
yvgOConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 11988534. (161 aa)
asnBAsparagine synthetase; Main asparagine synthetase in vegetative cells. (632 aa)
rpsDRibosomal protein S4 (BS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. S4 represses its own expression; it is not know if this is at the level of translation or of mRNA stability; Belongs to the universal ribosomal protein uS4 family. (200 aa)
araBL-ribulokinase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the ribulokinase family. (560 aa)
lepARibosomal elongation factor, GTPase; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (612 aa)
dnaKMolecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (611 aa)
ansAExported L-asparaginase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the asparaginase 1 family. (329 aa)
pelBPectin lyase; Catalyzes the depolymerization of pectins of methyl esterification degree from 13 to 75%, with an endo mode of action. Cannot degrade polygalacturonate (By similarity). (345 aa)
oppAOligopeptide ABC transporter (binding lipoprotein); This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, It binds peptides up to five amino acids long with high affinity. Also required for sporulation and competence. (545 aa)
phoAAlkaline phosphatase A; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the alkaline phosphatase family. (461 aa)
groELChaperonin large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
groESChaperonin small subunit; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. (94 aa)
amyEAlpha-amylase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme; Belongs to the glycosyl hydrolase 13 family. (659 aa)
ansZL-asparaginase 2 (putative lipoprotein); Catalyzes the conversion of L-asparagine to L-aspartate and ammonium. (375 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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