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dnaN dnaN dnaX dnaX holB holB pcrA pcrA ligA ligA yjcD yjcD polC polC mutS mutS mutL mutL yorL yorL yorK yorK ligB ligB xseB xseB xseA xseA holA holA recJ recJ mutSB mutSB dnaE dnaE helD helD ssbA ssbA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaNDNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] (378 aa)
dnaXDNA polymerase III (gamma and tau subunits); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. (563 aa)
holBDNA polymerase III delta' subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. (329 aa)
pcrAATP-dependent DNA helicase; DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. (739 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (668 aa)
yjcDPutative ATP-dependent DNA helicase; May be involved in the generation of recombinogenic substrates for the subsequent action of RecA. (759 aa)
polCDNA polymerase III (alpha subunit); Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity; Belongs to the DNA polymerase type-C family. PolC subfamily. (1437 aa)
mutSDNA mismatch repair recognition factor; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/mutY triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells. (858 aa)
mutLDNA mismatch repair factor; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/mutY triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo [...] (627 aa)
yorLPutative DNA polymerase; Probable DNA polymerase; Belongs to the DNA polymerase type-C family. (1305 aa)
yorKPutative single-strand DNA-specific exonuclease; Putative single-stranded-DNA-specific exonuclease. (576 aa)
ligBBacteriophage SPbeta DNA ligase; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type h: extrachromosomal origin; Belongs to the ATP-dependent DNA ligase family. (270 aa)
xseBExodeoxyribonuclease VII (small subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (84 aa)
xseAExodeoxyribonuclease VII (large subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (448 aa)
holADNA polymerase delta subunit; Evidence 2b: Function of strongly homologous gene; Product type e: enzyme. (347 aa)
recJPutative single-strand DNA-specific exonuclease; Putative single-stranded-DNA-specific exonuclease (By similarity). RecA thread formation during DNA double-strand break repair requires RecJ or AadAB; Belongs to the RecJ family. (786 aa)
mutSBPutative DNA mismatch repair enzyme; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (785 aa)
dnaEDNA polymerase III (alpha subunit); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. (1115 aa)
helDDNA 3'-5' helicase IV; Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP. (774 aa)
ssbASingle-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Has a 20-fold higher affinity for ssDNA than SsbB; SsbA and DprA activate the homologuos DNA strand exchange function of RecA-ATP. (172 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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