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| | AF_0018 | 3-ketoacyl-CoA thiolase (acaB-1); Similar to GB:L77117 PID:1592180 percent identity: 41.02; identified by sequence similarity; putative. (391 aa) |
| | AF_0035 | Mannosephosphate isomerase, putative; Similar to GB:D16594 PID:451216 SP:Q59935 percent identity: 31.30; identified by sequence similarity; putative. (299 aa) |
| | mat | Conserved hypothetical protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (399 aa) |
| | argD | Acetylornithine aminotransferase (argD-1); Similar to GB:L77117 SP:Q58131 PID:1591438 percent identity: 48.28; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (375 aa) |
| | AF_0108 | Conserved hypothetical protein; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | purP | Conserved hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (359 aa) |
| | AF_0116 | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (226 aa) |
| | AF_0133 | 3-ketoacyl-CoA thiolase (acaB-3); Similar to GB:L77117 PID:1592180 percent identity: 32.33; identified by sequence similarity; putative. (411 aa) |
| | AF_0140 | Ubiquinone/menaquinone biosynthesis methyltransferase (ubiE); Similar to GB:M87049 SP:P27851 PID:148231 GB:U00096 PID:2367307 percent identity: 31.00; identified by sequence similarity; putative. (261 aa) |
| | AF_0209 | Conserved hypothetical protein; Similar to SP:P26615 GB:M87049 GB:X65013 PID:148243 percent identity: 42.53; identified by sequence similarity; putative; Belongs to the UbiD family. (481 aa) |
| | hisD | Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (404 aa) |
| | leuA | 2-isopropylmalate synthase (leuA-2); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (503 aa) |
| | AF_0227 | Chorismate mutase/prephenate dehydratase (pheA); Similar to GB:L42023 SP:P43900 PID:1006481 PID:1221267 PID:1205390 percent identity: 32.15; identified by sequence similarity; putative. (620 aa) |
| | aroD | 3-dehydroquinate dehydratase (aroD); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (196 aa) |
| | aroB | Conserved hypothetical protein; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (323 aa) |
| | aroA | Conserved hypothetical protein; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | AF_0242 | Glucose-1-phosphate thymidylyltransferase (graD-1); Similar to PID:763512 percent identity: 27.69; identified by sequence similarity; putative. (332 aa) |
| | AF_0256 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57600 PID:1498904 percent identity: 39.08; identified by sequence similarity; putative. (373 aa) |
| | gltX | glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (551 aa) |
| | AF_0283 | 3-ketoacyl-CoA thiolase (acaB-7); Similar to GB:L77117 PID:1592180 percent identity: 41.99; identified by sequence similarity; putative. (396 aa) |
| | AF_0324 | dTDP-glucose 4,6-dehydratase (rfbB); Similar to PID:567874 percent identity: 50.00; identified by sequence similarity; putative. (332 aa) |
| | AF_0325 | Glucose-1-phosphate thymidylyltransferase (graD-2); Similar to PID:763512 percent identity: 43.11; identified by sequence similarity; putative. (352 aa) |
| | AF_0343 | Tryptophan repressor binding protein (wrbA); It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide. It prefers NADH over NADPH; Belongs to the WrbA family. (191 aa) |
| | AF_0366 | acetyl-CoA synthetase (acs-2); Similar to PID:1001216 PID:1001254 percent identity: 47.28; identified by sequence similarity; putative. (681 aa) |
| | mqnA | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (249 aa) |
| | mqnC | Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (355 aa) |
| | AF_0409 | Aspartate aminotransferase (aspB-4); Similar to PID:1001492 PID:1001578 percent identity: 45.24; identified by sequence similarity; putative. (386 aa) |
| | AF_0422 | uroporphyrin-III C-methyltransferase (cysG-1); Similar to GB:L77117 PID:1591629 percent identity: 41.74; identified by sequence similarity; putative. (243 aa) |
| | AF_0438 | 3-ketoacyl-CoA thiolase (acaB-8); Similar to GB:L77117 PID:1592180 percent identity: 42.41; identified by sequence similarity; putative. (387 aa) |
| | AF_0444 | Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (223 aa) |
| | AF_0458 | Phosphomannomutase (pmm); Similar to GB:L77117 PID:1591745 percent identity: 39.46; identified by sequence similarity; putative; Belongs to the phosphohexose mutase family. (446 aa) |
| | korB | 2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:L77117 PID:1591241 percent identity: 51.38; identified by sequence similarity; putative. (267 aa) |
| | korA | 2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:L77117 PID:1592279 percent identity: 52.34; identified by sequence similarity; putative. (346 aa) |
| | AF_0470 | 2-ketoglutarate ferredoxin oxidoreductase, subunit delta (korD); Similar to GB:L77117 SP:Q57610 PID:1498915 percent identity: 47.17; identified by sequence similarity; putative. (67 aa) |
| | korC | 2-ketoglutarate ferredoxin oxidoreductase, subunit gamma (korG); Similar to GB:L77117 PID:1591240 percent identity: 40.00; identified by sequence similarity; putative. (187 aa) |
| | ribA | GTP cyclohydrolase II (ribA-1); Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; In the N-terminal section; belongs to the DHBP synthase family. (378 aa) |
| | AF_0498 | acyl-coA dehydrogenase (acd-3); Similar to SP:P41367 percent identity: 22.90; identified by sequence similarity; putative. (576 aa) |
| | AF_0512 | Chloroplast inner envelope membrane protein; Similar to SP:P23525 percent identity: 42.49; identified by sequence similarity; putative. (205 aa) |
| | aroK | Conserved hypothetical protein; Similar to GB:L77117 PID:1500322 percent identity: 34.44; identified by sequence similarity; putative. (280 aa) |
| | AF_0522 | Acetylornithine deacetylase (argE); Similar to GB:L77117 PID:1592133 percent identity: 29.58; identified by sequence similarity; putative. (316 aa) |
| | AF_0551 | Threonine synthase (thrC-1); Similar to GB:L77117 PID:1592106 percent identity: 40.50; identified by sequence similarity; putative. (404 aa) |
| | prs1 | Ribose-phosphate pyrophosphokinase (prsA-1); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (304 aa) |
| | hisG | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (leuB); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (326 aa) |
| | leuD1 | 3-isopropylmalate dehydratase, small subunit (leuD-1); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | icd | Isocitrate dehydrogenase, NADP (icd); Similar to GB:J02799 SP:P08200 PID:146432 GB:U00096 PID:1651560 percent identity: 57.18; identified by sequence similarity; putative; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (412 aa) |
| | aroC | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | adk | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | AF_0681 | Succinate dehydrogenase, flavoprotein subunit A (sdhA); Similar to GP:1524302 percent identity: 48.23; identified by sequence similarity; putative. (563 aa) |
| | AF_0682 | Succinate dehydrogenase, iron-sulfur subunit B (sdhB); Similar to GB:X70908 PID:396212 percent identity: 51.27; identified by sequence similarity; putative. (236 aa) |
| | AF_0683 | Succinate dehydrogenase, subunit C (sdhC); Similar to GP:1524299 percent identity: 36.56; identified by sequence similarity; putative. (124 aa) |
| | sdhD | Succinate dehydrogenase, subunit D (sdhD); Membrane-anchoring subunit of succinate dehydrogenase (SDH). (117 aa) |
| | AF_0700 | Aspartate kinase (lysC); Similar to GB:L77117 SP:Q57991 PID:1591278 percent identity: 49.13; identified by sequence similarity; putative; Belongs to the aspartokinase family. (462 aa) |
| | ppsA | Phosphoenolpyruvate synthase (ppsA); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (753 aa) |
| | AF_0713 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA-1); Similar to GB:L77117 SP:Q58114 PID:1591418 percent identity: 37.50; identified by sequence similarity; putative; Belongs to the HisA/HisF family. (223 aa) |
| | dapF | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (280 aa) |
| | AF_0749 | 2-oxoacid ferredoxin oxidoreductase, subunit alpha (orA); Similar to GP:1565183 percent identity: 33.70; identified by sequence similarity; putative. (532 aa) |
| | AF_0750 | 2-oxoacid ferredoxin oxidoreductase, subunit beta (orB); Similar to GP:1565184 percent identity: 49.21; identified by sequence similarity; putative. (245 aa) |
| | ndk | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa) |
| | lysA | Diaminopimelate decarboxylase (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | serA | Phosphoglycerate dehydrogenase (serA); Similar to GB:L77117 PID:1591676 percent identity: 48.77; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (271 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (451 aa) |
| | mdh | L-malate dehydrogenase, NAD+-dependent (mdhA); Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. (294 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)+) (gpsA); Similar to SP:P46919 PID:974332 PID:1146220 GB:AL009126 percent identity: 36.31; identified by sequence similarity; putative. (335 aa) |
| | purF | Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (457 aa) |
| | argH | Argininosuccinate lyase (argH); Similar to SP:Q58201 PID:1591489 GB:L77117 SP:Q58201 PID:1591489 percent identity: 42.23; identified by sequence similarity; putative. (483 aa) |
| | dapB | Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (257 aa) |
| | dapA | Dihydrodipicolinate synthase (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | ilvE | Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa) |
| | AF_0935 | Homoserine dehydrogenase (hom); Similar to GB:L77117 PID:1500499 percent identity: 47.85; identified by sequence similarity; putative. (326 aa) |
| | surE | surE stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa) |
| | rpiA | Ribose 5-phosphate isomerase (rpi); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa) |
| | AF_0964 | acyl-CoA dehydrogenase (acd-6); Similar to PID:1055219 SP:P52042 percent identity: 35.77; identified by sequence similarity; putative. (394 aa) |
| | AF_0968 | 3-ketoacyl-CoA thiolase (acaB-10); Similar to GB:L77117 PID:1592180 percent identity: 27.98; identified by sequence similarity; putative. (388 aa) |
| | AF_0975 | acetyl-CoA synthetase (acs-4); Similar to GB:M63968 SP:P27095 PID:150032 percent identity: 42.26; identified by sequence similarity; putative. (642 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydrogenase/histidinol-phosphatase (hisB); Similar to GB:L77117 SP:Q58109 PID:1591413 percent identity: 42.24; identified by sequence similarity; putative. (178 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA-2); Similar to GB:L77117 SP:Q58927 PID:1592163 percent identity: 42.24; identified by sequence similarity; putative. (238 aa) |
| | AF_0991 | glutaryl-CoA dehydrogenase (gcdH); Similar to GB:U69141 SP:Q92947 PID:1549327 PID:1905909 PID:2316112 percent identity: 48.68; identified by sequence similarity; putative. (395 aa) |
| | ilvD | Dihydroxy-acid dehydratase (ilvD); Similar to GB:L77117 PID:1591912 percent identity: 54.55; identified by sequence similarity; putative; Belongs to the IlvD/Edd family. (547 aa) |
| | AF_1028 | 3-ketoacyl-CoA thiolase (fadA-1); Similar to GP:1742272 percent identity: 38.83; identified by sequence similarity; putative. (396 aa) |
| | AF_1097 | Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase (manC); Similar to PID:559389 percent identity: 43.08; identified by sequence similarity; putative; Belongs to the mannose-6-phosphate isomerase type 2 family. (448 aa) |
| | AF_1098 | Fumarase (fum-1); Similar to GB:L77117 SP:Q58034 PID:1591328 percent identity: 49.13; identified by sequence similarity; putative. (180 aa) |
| | AF_1099 | Fumarase (fum-2); Similar to GB:L77117 SP:Q58690 PID:1591932 percent identity: 53.38; identified by sequence similarity; putative. (272 aa) |
| | AF_1125 | Heme biosynthesis protein (nirJ-1); Similar to GP:1783281 percent identity: 38.73; identified by sequence similarity; putative. (377 aa) |
| | eno | Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (366 aa) |
| | pgk | 3-phosphoglycerate kinase (pgk); Similar to GB:L77117 SP:Q58058 PID:1592299 percent identity: 48.77; identified by sequence similarity; putative. (407 aa) |
| | argJ | Glutamate N-acetyltransferase (argJ); Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (379 aa) |
| | purD | Phosphoribosylamine--glycine ligase (purD); Similar to GB:L42023 SP:P43845 PID:1005977 PID:1220991 PID:1205135 percent identity: 40.90; identified by sequence similarity; putative. (470 aa) |
| | ubiX | Phenylacrylic acid decarboxylase (pad1); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (182 aa) |
| | trpB2 | Tryptophan synthase, subunit beta (trpB-1); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (435 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:L77117 SP:Q58020 PID:1591312 percent identity: 54.31; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (418 aa) |
| | hemC | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (289 aa) |
| | AF_1243 | uroporphyrin-III C-methyltransferase (cysG-2); Similar to GB:L77117 PID:1591629 percent identity: 52.52; identified by sequence similarity; putative. (244 aa) |
| | argF | Ornithine carbamoyltransferase (argF); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to a [...] (271 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase (purE); Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide synthase (purC); Similar to GB:L77117 PID:1592203 percent identity: 34.71; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. Highly divergent. (331 aa) |
| | argB | Acetylglutamate kinase (argB); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | AF_1291 | 3-ketoacyl-CoA thiolase (acaB-11); Similar to GB:L77117 PID:1592180 percent identity: 40.10; identified by sequence similarity; putative. (392 aa) |
| | tpiA | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | AF_1316 | Threonine synthase (thrC-2); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (396 aa) |
| | AF_1328 | Glycerol-3-phosphate dehydrogenase (glpA); Similar to GB:L43967 PID:1045710 SP:P47285 percent identity: 27.82; identified by sequence similarity; putative. (453 aa) |
| | AF_1340 | Citrate synthase (citZ); Similar to GB:U05257 SP:P39120 PID:487433 PID:2293267 GB:AL009126 percent identity: 50.27; identified by sequence similarity; putative. (372 aa) |
| | ribC | Riboflavin synthase (ribC); Similar to GB:L77117 PID:1591811 percent identity: 53.33; identified by sequence similarity; putative; Belongs to the DMRL synthase family. (153 aa) |
| | ribL | Glycerol-3-phosphate cytidyltransferase (taqD); Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (137 aa) |
| | prs2 | Ribose-phosphate pyrophosphokinase (prsA-2); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (271 aa) |
| | apgM2 | Phosphonopyruvate decarboxylase (bcpC-1); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (380 aa) |
| | AF_1439 | Asparagine synthetase (asnB); Similar to GB:L77117 SP:Q58516 PID:1591755 percent identity: 36.88; identified by sequence similarity; putative. (371 aa) |
| | fbp | Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (370 aa) |
| | AF_1445 | Conserved hypothetical protein; Similar to GP:1524204 percent identity: 26.18; identified by sequence similarity; putative. (495 aa) |
| | AF_1494 | Predicted coding region AF_1494; Hypothetical protein; identified by GeneMark; putative. (235 aa) |
| | aroA-2 | 5-enolpyruvylshikimate 3-phosphate synthase (aroA); Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (416 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | sucD1 | succinyl-CoA synthetase, alpha subunit (sucD-1); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa) |
| | sucC1 | succinyl-CoA synthetase, beta subunit (sucC-1); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa) |
| | AF_1551 | Octaprenyl-diphosphate synthase (ispB); Similar to GB:L42023 SP:P44916 PID:1005963 PID:1220984 PID:1205128 percent identity: 33.20; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. (292 aa) |
| | AF_1592 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57605 PID:1590903 percent identity: 30.69; identified by sequence similarity; putative. (251 aa) |
| | trpA | Tryptophan synthase, subunit alpha (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (248 aa) |
| | trpB1 | Tryptophan synthase, subunit beta (trpB-2); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpF | Phosphoribosyl anthranilate isomerase (trpF); Similar to PID:1054860 SP:Q56320 percent identity: 37.06; identified by sequence similarity; putative; Belongs to the TrpF family. (199 aa) |
| | trpG | Anthranilate synthase component II (trpG); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (178 aa) |
| | trpE | Anthranilate synthase component I (trpE) {Methanococcus jannaschii); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly [...] (411 aa) |
| | trpCD | Anthranilate synthase component II (trpD); Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain (By similarity). (546 aa) |
| | rbcL | Ribulose bisphosphate carboxylase, large subunit (rbcL-2); Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (441 aa) |
| | sat | Sulfate adenylyltransferase (sat); Similar to PID:1653421 percent identity: 28.39; identified by sequence similarity; putative; Belongs to the sulfate adenylyltransferase family. (459 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:L77117 SP:Q57656 PID:1590946 percent identity: 53.77; identified by sequence similarity; putative. (329 aa) |
| | AF_1695 | Thiamine biosynthesis protein (apbA); Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. (294 aa) |
| | AF_1699 | Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 50.84; identified by sequence similarity; putative. (191 aa) |
| | AF_1700 | Pyruvate ferredoxin oxidoreductase, subunit delta (porD); Similar to PID:1197359 percent identity: 53.12; identified by sequence similarity; putative. (97 aa) |
| | AF_1701 | Pyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1590995 percent identity: 50.27; identified by sequence similarity; putative. (391 aa) |
| | AF_1702 | Pyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to GB:L77117 PID:1590994 percent identity: 50.70; identified by sequence similarity; putative. (294 aa) |
| | mqnD | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (271 aa) |
| | ilvH | Acetolactate synthase, small subunit (ilvN); Similar to GB:L77117 SP:Q57625 PID:1590918 percent identity: 60.38; identified by sequence similarity; putative; Belongs to the acetolactate synthase small subunit family. (159 aa) |
| | AF_1720 | Acetolactate synthase, large subunit (ilvB-1); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 57.48; identified by sequence similarity; putative. (552 aa) |
| | gap | Glyceraldehyde 3-phosphate dehydrogenase (gap); Similar to SP:P10618 PID:149792 percent identity: 56.59; identified by sequence similarity; putative. (340 aa) |
| | hmgA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA); Converts HMG-CoA to mevalonate. (436 aa) |
| | apgM1 | Phosphonopyruvate decarboxylase (bcpC-2); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily. (408 aa) |
| | leuD2 | 3-isopropylmalate dehydratase, small subunit (leuD-2); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | AF_1780 | Acetolactate synthase, large subunit (ilvB-2); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 32.06; identified by sequence similarity; putative; Belongs to the TPP enzyme family. (545 aa) |
| | AF_1794 | Myo-inositol-1-phosphate synthase (ino1); Similar to SP:P11986 PID:1015571 PID:854544 percent identity: 32.24; identified by sequence similarity; putative. (392 aa) |
| | AF_1811 | Inosine monophosphate cyclohydrolase; Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 38.27; identified by sequence similarity; putative. (157 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (765 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (80 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (108 aa) |
| | leuC1 | Aconitase (acn); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (433 aa) |
| | hemB | Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). (322 aa) |
| | hemA | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (437 aa) |
| | ilvC | Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate. It is able to use both NADPH and NADH, but has a preference for NADH. (332 aa) |
| | AF_2001 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (178 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase (hisC-1); Similar to GB:L77117 PID:1591622 percent identity: 39.76; identified by sequence similarity; putative. (319 aa) |
| | mfnA | Group II decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (367 aa) |
| | AF_2015 | Acetolactate synthase, large subunit (ilvB-3); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 34.07; identified by sequence similarity; putative; Belongs to the TPP enzyme family. (543 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase (hisC-2); Similar to GB:L77117 PID:1591622 percent identity: 36.83; identified by sequence similarity; putative. (342 aa) |
| | ctaB | Cytochrome C oxidase folding protein (coxD); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (281 aa) |
| | AF_2044 | CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA); Similar to GB:L77117 SP:Q58609 PID:1591841 percent identity: 36.65; identified by sequence similarity; putative. (221 aa) |
| | asd-2 | Phosphatidylserine decarboxylase (psd2); Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer). (195 aa) |
| | AF_2052 | 2-ketoisovalerate ferredoxin oxidoreductase, subunit beta (vorB); Similar to PID:1197361 percent identity: 42.65; identified by sequence similarity; putative. (278 aa) |
| | AF_2053 | 2-ketoisovalerate ferredoxin oxidoreductase, subunit alpha (vorA); Similar to PID:1197363 percent identity: 41.16; identified by sequence similarity; putative. (366 aa) |
| | AF_2054 | 2-ketoisovalerate ferredoxin oxidoreductase, subunit delta (vorD); Similar to PID:1197359 percent identity: 51.52; identified by sequence similarity; putative. (82 aa) |
| | AF_2055 | 2-ketoisovalerate ferredoxin oxidoreductase, subunit gamma (vorG); Similar to PID:1197358 percent identity: 45.21; identified by sequence similarity; putative. (172 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase (argC); Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (332 aa) |
| | AF_2100 | Acetolactate synthase, large subunit (ilvB-4); Similar to GB:L77117 SP:Q57725 PID:1591003 percent identity: 38.42; identified by sequence similarity; putative; Belongs to the TPP enzyme family. (575 aa) |
| | ribB | GTP cyclohydrolase II (ribA-2); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (238 aa) |
| | AF_2112 | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE); Similar to PID:1103707 SP:P55299 percent identity: 28.08; identified by sequence similarity; putative. (311 aa) |
| | ribH | Riboflavin synthase, subunit beta (ribE); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (143 aa) |
| | AF_2129 | Aspartate aminotransferase (aspB-2); Similar to PID:1146246 SP:P53001 GB:AL009126 percent identity: 45.38; identified by sequence similarity; putative. (379 aa) |
| | AF_2138 | Phosphoserine phosphatase (serB); Similar to GB:L77117 PID:1592204 percent identity: 50.71; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. SerB family. (344 aa) |
| | AF_2176 | 4-hydroxybenzoate octaprenyltransferase (ubiA); Similar to GP:1813467 percent identity: 41.61; identified by sequence similarity; putative. (291 aa) |
| | sucD2 | succinyl-CoA synthetase, alpha subunit (sucD-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (287 aa) |
| | sucC2 | succinyl-CoA synthetase, beta subunit (sucC-2); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (380 aa) |
| | leuC2 | 3-isopropylmalate dehydratase, large subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | katG | Peroxidase / catalase (perA); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activity. (741 aa) |
| | purB | Adenylosuccinate lyase (purB); Similar to GB:L77117 PID:1591600 percent identity: 52.27; identified by sequence similarity; putative. (444 aa) |
| | argG | Argininosuccinate synthetase (argG); Similar to GB:L77117 SP:Q60174 PID:1591132 percent identity: 62.02; identified by sequence similarity; putative; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (390 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase, subunit H (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (197 aa) |
| | AF_2286 | Geranylgeranyl diphosphate synthase, type I; Similar to PID:913252 SP:Q53479 percent identity: 42.68; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. (326 aa) |
| | fni | Carotenoid biosynthetic gene ERWCRTS, putative; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (317 aa) |
| | AF_2288 | Acetylglutamate kinase, putative; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (240 aa) |
| | mvk | Mevalonate kinase (mvk); Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (284 aa) |
| | aroE | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | AF_2366 | Aspartate aminotransferase (aspB-1); Similar to GB:L77117 SP:Q60317 PID:1592252 percent identity: 42.31; identified by sequence similarity; putative. (373 aa) |
| | suhB | Extragenic suppressor (suhB); Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate. (252 aa) |
| | AF_2413 | Coenzyme PQQ synthesis protein (pqqE); Similar to SP:P27507 PID:809708 percent identity: 30.47; identified by sequence similarity; putative. (375 aa) |
| | AF_2415 | Acyl carrier protein synthase (acaA-2); Similar to PID:1197357 percent identity: 58.72; identified by sequence similarity; putative; Belongs to the thiolase-like superfamily. UPF0219 family. (303 aa) |
| | AF_2416 | 3-ketoacyl-CoA thiolase (acaB-12); Similar to GB:L77117 PID:1592180 percent identity: 49.87; identified by sequence similarity; putative. (384 aa) |
