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hisG hisG hisB hisB hisH hisH hisC hisC hisA hisA hisD hisD hisI hisI trpD trpD trpA trpA trpB trpB trpF trpF trpC trpC trpG trpG trpE trpE hisE hisE hisF hisF
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hisGATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
hisHImidazole glycerol phosphate synthase glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa)
hisCHistidinol-phosphate aminotransferase HisC. (365 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA. (246 aa)
hisDHistidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
hisIphosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa)
trpDAnthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (355 aa)
trpATryptophan synthase alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
trpBTryptophan synthase subunit beta TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (222 aa)
trpCIndole-3-glycerol-phosphate synthase TrpC. (265 aa)
trpGAnthranilate synthase component II TrpG. (188 aa)
trpEAnthranilate synthase component I TrpE. (415 aa)
hisEphosphoribosyl-ATP pyrophosphohydrolase HisE. (96 aa)
hisFImidazoleglycerol-phosphate synthase cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (281 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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