(12 nodes) Endoribonuclease activity network (Methanobrevibacter sp. AbM4)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	rnp4	Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa)
	rnp1	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (93 aa)
	rnp2	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa)
	rnhB	Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (207 aa)
	endA	tRNA intron endonuclease EndA. (171 aa)
	rpl7ae	Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
	rnc	Ribonuclease III Rnc. (222 aa)
	rnz	Ribonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (297 aa)
	rnp3	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (244 aa)
	Abm4_0049	Ribonuclease. (152 aa)
	cas2	CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (87 aa)
	cas2-2	CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa)

Your Current Organism:

Methanobrevibacter sp. AbM4

NCBI taxonomy Id: 224719
Other names: M. sp. AbM4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
endA	rnp1	Abm4_0704	Abm4_1268	tRNA intron endonuclease EndA.	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	0.422
endA	rnp4	Abm4_0704	Abm4_0194	tRNA intron endonuclease EndA.	Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.413
rnc	rnhB	Abm4_0801	Abm4_1494	Ribonuclease III Rnc.	Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.611
rnc	rnz	Abm4_0801	Abm4_1367	Ribonuclease III Rnc.	Ribonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.	0.598
rnc	rpl7ae	Abm4_0801	Abm4_0709	Ribonuclease III Rnc.	Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.453
rnhB	rnc	Abm4_1494	Abm4_0801	Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Ribonuclease III Rnc.	0.611
rnhB	rnz	Abm4_1494	Abm4_1367	Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	Ribonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.	0.524
rnp1	endA	Abm4_1268	Abm4_0704	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	tRNA intron endonuclease EndA.	0.422
rnp1	rnp2	Abm4_1268	Abm4_0923	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	0.936
rnp1	rnp3	Abm4_1268	Abm4_0924	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	0.951
rnp1	rnp4	Abm4_1268	Abm4_0194	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.966
rnp1	rpl7ae	Abm4_1268	Abm4_0709	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.815
rnp2	rnp1	Abm4_0923	Abm4_1268	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	0.936
rnp2	rnp3	Abm4_0923	Abm4_0924	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	0.998
rnp2	rnp4	Abm4_0923	Abm4_0194	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.992
rnp2	rpl7ae	Abm4_0923	Abm4_0709	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.896
rnp3	rnp1	Abm4_0924	Abm4_1268	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	0.951
rnp3	rnp2	Abm4_0924	Abm4_0923	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	0.998
rnp3	rnp4	Abm4_0924	Abm4_0194	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.995
rnp3	rpl7ae	Abm4_0924	Abm4_0709	Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.964