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dusA1 dusA1 Abm4_0080 Abm4_0080 Abm4_0099 Abm4_0099 truD truD rnp4 rnp4 Abm4_0215 Abm4_0215 rtcB rtcB Abm4_0249 Abm4_0249 thiI thiI Abm4_0269 Abm4_0269 Abm4_0323 Abm4_0323 taw1 taw1 thgL thgL tiaS tiaS Abm4_0434 Abm4_0434 Abm4_0435 Abm4_0435 truA truA Abm4_0525 Abm4_0525 Abm4_0530 Abm4_0530 Abm4_0612 Abm4_0612 cca cca endA endA rpl7ae rpl7ae Abm4_0768 Abm4_0768 Abm4_0914 Abm4_0914 rnp2 rnp2 rnp3 rnp3 Abm4_0968 Abm4_0968 Abm4_0970 Abm4_0970 tgtA tgtA Abm4_1029 Abm4_1029 Abm4_1201 Abm4_1201 cbf5p cbf5p rnp1 rnp1 Abm4_1310 Abm4_1310 Abm4_1316 Abm4_1316 rnz rnz Abm4_1419 Abm4_1419 Abm4_1424 Abm4_1424 Abm4_1455 Abm4_1455 dusA2 dusA2 Abm4_1541 Abm4_1541 trm1 trm1 taw2 taw2 flpA flpA pus10 pus10 Abm4_1715 Abm4_1715
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dusA1tRNA-dihydrouridine synthase DusA1. (329 aa)
Abm4_0080Universal archaeal protein Kae1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (549 aa)
Abm4_0099tRNA(1-methyladenosine) methyltransferase. (243 aa)
truDtRNA pseudouridine synthase D TruD; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (427 aa)
rnp4Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa)
Abm4_0215Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. (154 aa)
rtcBHypothetical protein; Belongs to the RtcB family. (482 aa)
Abm4_0249PUA domain-containing protein. (304 aa)
thiIThiamine biosynthesis ATP pyrophosphatase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa)
Abm4_0269Sua5/YciO/YrdC/YwlC family translation factor. (196 aa)
Abm4_0323Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (181 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (306 aa)
thgLtRNA(His) guanylyltransferase ThgL. (282 aa)
tiaSDNA-binding protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (405 aa)
Abm4_04344Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (267 aa)
Abm4_0435Hypothetical protein. (134 aa)
truAtRNA pseudouridine synthase A TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (296 aa)
Abm4_0525MiaB-like tRNA modifying enzyme. (429 aa)
Abm4_0530Histone acetyltransferase ELP3 family. (570 aa)
Abm4_0612Hypothetical protein. (136 aa)
ccatRNA nucleotidyltransferase Cca; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (461 aa)
endAtRNA intron endonuclease EndA. (171 aa)
rpl7aeRibosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
Abm4_0768Hypothetical protein. (164 aa)
Abm4_0914Hypothetical protein. (89 aa)
rnp2Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa)
rnp3Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (244 aa)
Abm4_0968Hypothetical protein. (169 aa)
Abm4_0970RNA methylase. (343 aa)
tgtAArchaeosine tRNA-ribosyltransferase TgtA; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (659 aa)
Abm4_1029Hypothetical protein. (408 aa)
Abm4_12014Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (241 aa)
cbf5pH/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa)
rnp1Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (93 aa)
Abm4_1310Archaeosine tRNA-ribosyltransferase family protein. (249 aa)
Abm4_1316Met-10+ like-protein. (361 aa)
rnzRibonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (297 aa)
Abm4_1419Radical SAM domain-containing protein. (364 aa)
Abm4_1424PP-loop family protein. (310 aa)
Abm4_14554Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (244 aa)
dusA2tRNA-dihydrouridine synthase DusA2. (236 aa)
Abm4_1541PP-loop family protein. (285 aa)
trm1N2,N2-dimethylguanosine tRNA methyltransferase Trm1; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (398 aa)
taw2Met-10+ like-protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (251 aa)
flpAFibrillarin FlpA; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (216 aa)
pus10Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (409 aa)
Abm4_1715Methanogenesis marker protein 11. (310 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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