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Abm4_0219 Abm4_0219 Abm4_0220 Abm4_0220 Abm4_0223 Abm4_0223 Abm4_0229 Abm4_0229 tyrA tyrA Abm4_0243 Abm4_0243 Abm4_0268 Abm4_0268 Abm4_0315 Abm4_0315 korD korD korA korA korB korB korC korC Abm4_0332 Abm4_0332 cbiJ cbiJ Abm4_0376 Abm4_0376 Abm4_0383 Abm4_0383 cofA cofA nadX1 nadX1 Abm4_1711 Abm4_1711 serA serA Abm4_0420 Abm4_0420 Abm4_0434 Abm4_0434 Abm4_0435 Abm4_0435 Abm4_0491 Abm4_0491 Abm4_0497 Abm4_0497 argC argC Abm4_0538 Abm4_0538 Abm4_0541 Abm4_0541 dapB dapB asd asd Abm4_0555 Abm4_0555 Abm4_0568 Abm4_0568 Abm4_0583 Abm4_0583 Abm4_0588 Abm4_0588 Abm4_0612 Abm4_0612 Abm4_0629 Abm4_0629 Abm4_0631 Abm4_0631 npdG1 npdG1 Abm4_0650 Abm4_0650 aroB aroB ribD ribD hisD hisD Abm4_0681 Abm4_0681 proC proC Abm4_0692 Abm4_0692 hdrC1 hdrC1 hdrB1 hdrB1 hdrA1 hdrA1 fprA1 fprA1 Abm4_0727 Abm4_0727 Abm4_0728 Abm4_0728 Abm4_0733 Abm4_0733 Abm4_0742 Abm4_0742 hdrB3 hdrB3 Abm4_0759 Abm4_0759 guaB guaB Abm4_1713 Abm4_1713 Abm4_0776 Abm4_0776 aroE aroE trxB trxB hom hom Abm4_0813 Abm4_0813 frhB2 frhB2 gdhA gdhA panE panE gor gor mvhD2 mvhD2 fdhB2 fdhB2 fdhA2 fdhA2 Abm4_0856 Abm4_0856 hmgA hmgA Abm4_0927 Abm4_0927 Abm4_0934 Abm4_0934 ehaQ ehaQ ehaP ehaP ehaO ehaO Abm4_0971 Abm4_0971 gltA gltA gltB gltB aksF aksF Abm4_1002 Abm4_1002 Abm4_1029 Abm4_1029 Abm4_1093 Abm4_1093 Abm4_1094 Abm4_1094 Abm4_1113 Abm4_1113 Abm4_1114 Abm4_1114 Abm4_1130 Abm4_1130 Abm4_1157 Abm4_1157 hbd hbd Abm4_1169 Abm4_1169 Abm4_1178 Abm4_1178 dfx dfx Abm4_1201 Abm4_1201 nox nox egsA egsA fni fni Abm4_1233 Abm4_1233 Abm4_1291 Abm4_1291 Abm4_1292 Abm4_1292 Abm4_1297 Abm4_1297 hdrB2 hdrB2 hdrC2 hdrC2 Abm4_1314 Abm4_1314 iorB iorB iorA iorA sdhB sdhB dusA1 dusA1 Abm4_1357 Abm4_1357 Abm4_1383 Abm4_1383 mer mer rfbD rfbD Abm4_1421 Abm4_1421 porC porC porD porD porA porA porB porB porE porE porF porF Abm4_1448 Abm4_1448 Abm4_1455 Abm4_1455 Abm4_1462 Abm4_1462 Abm4_1463 Abm4_1463 Abm4_1464 Abm4_1464 gap gap hemA hemA cysG cysG dusA2 dusA2 mvhB mvhB mvhA mvhA mvhG mvhG mvhD mvhD comC comC hcp hcp pyrK pyrK pyrD pyrD ehbO ehbO ehbN ehbN ehbL ehbL ehbK ehbK ehbF ehbF nadX2 nadX2 npdG2 npdG2 Abm4_1628 Abm4_1628 Abm4_1629 Abm4_1629 frhB1 frhB1 frhG frhG frhA frhA Abm4_1671 Abm4_1671 fprA2 fprA2 Abm4_1681 Abm4_1681 hdrA2 hdrA2 afpA afpA leuB leuB hmd hmd sdhA sdhA mtd mtd Abm4_0043 Abm4_0043 ilvC ilvC Abm4_0088 Abm4_0088 Abm4_0121 Abm4_0121 fdhA fdhA fdhB fdhB fwdH fwdH fwdF fwdF fwdG fwdG fwdD fwdD fwdB fwdB fwdC fwdC nrdD nrdD Abm4_0170 Abm4_0170 Abm4_0218 Abm4_0218
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Abm4_0219NADPH-dependent FMN reductase. (172 aa)
Abm4_0220Dinitrogenase iron-molybdenum cofactor biosynthesis protein. (113 aa)
Abm4_0223Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (62 aa)
Abm4_0229Anaerobic ribonucleoside-triphosphate reductase activating protein. (236 aa)
tyrAPrephenate dehydrogenase TyrA. (435 aa)
Abm4_0243Dihydrolipoamide dehydrogenase-related protein. (427 aa)
Abm4_0268NADPH-dependent FMN reductase. (250 aa)
Abm4_0315Nitroreductase family protein. (264 aa)
korD2-oxoglutarate ferredoxin oxidoreductase subunit delta KorD. (88 aa)
korA2-oxoglutarate ferredoxin oxidoreductase subunit alpha KorA. (377 aa)
korB2-oxoglutarate ferredoxin oxidoreductase subunit beta KorB. (310 aa)
korC2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC. (183 aa)
Abm4_0332NADPH-dependent FMN reductase. (232 aa)
cbiJPrecorrin-6x reductase CbiJ. (273 aa)
Abm4_0376Nitrite and sulphite reductase 4Fe-4S region. (690 aa)
Abm4_03834Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (253 aa)
cofALactaldehyde dehydrogenase CofA; Belongs to the aldehyde dehydrogenase family. (470 aa)
nadX1L-aspartate dehydrogenase NadX1; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (254 aa)
Abm4_1711Nucleotide sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (418 aa)
serAPhosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa)
Abm4_0420Nitroreductase family protein. (167 aa)
Abm4_04344Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (267 aa)
Abm4_0435Hypothetical protein. (134 aa)
Abm4_0491GMC oxidoreductase family protein. (403 aa)
Abm4_0497Flavodoxin. (163 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
Abm4_0538NADH-dependent flavin oxidoreductase. (336 aa)
Abm4_0541Redox-active disulfide protein. (81 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
Abm4_0555Flavoredoxin. (187 aa)
Abm4_0568Oxidoreductase aldo/keto reductase family. (375 aa)
Abm4_0583Hypothetical protein. (296 aa)
Abm4_0588Pyridoxamine 5'-phosphate oxidase family protein. (134 aa)
Abm4_0612Hypothetical protein. (136 aa)
Abm4_0629Hypothetical protein. (278 aa)
Abm4_06314Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (255 aa)
npdG1NADPH-dependent F420 reductase NpdG1. (227 aa)
Abm4_0650Nitroreductase family protein. (169 aa)
aroB3-dehydroquinate synthase AroB; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (378 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine reductase RibD. (219 aa)
hisDHistidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
Abm4_0681NADPH-dependent FMN reductase. (202 aa)
proCPyrroline-5-carboxylate reductase ProC. (271 aa)
Abm4_0692Methanogenesis marker protein 16. (426 aa)
hdrC1CoB--CoM heterodisulfide reductase subunit C HdrC1. (204 aa)
hdrB1CoB--CoM heterodisulfide reductase subunit B HdrB1. (348 aa)
hdrA1CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa)
fprA1F420H2 oxidase FprA1. (409 aa)
Abm4_07274Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (54 aa)
Abm4_0728Geranylgeranyl reductase family protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (399 aa)
Abm4_07334Fe-4S iron sulfur cluster binding protein NifH/frxC family; Belongs to the NifH/BchL/ChlL family. (267 aa)
Abm4_0742Radical SAM domain-containing protein. (376 aa)
hdrB3CoB--CoM heterodisulfide reductase subunit B HdrB3. (232 aa)
Abm4_0759Iron-sulfur cluster-binding protein. (404 aa)
guaBInosine-5'-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
Abm4_1713Nucleotide sugar dehydrogenase. (442 aa)
Abm4_0776Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (53 aa)
aroEShikimate 5-dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (293 aa)
trxBThioredoxin-disulfide reductase TrxB. (312 aa)
homHomoserine dehydrogenase Hom. (340 aa)
Abm4_0813Oxidoreductase aldo/keto reductase family. (381 aa)
frhB2Coenzyme F420 hydrogenase beta subunit FrhB2. (360 aa)
gdhAGlutamate dehydrogenase GdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa)
panE2-dehydropantoate 2-reductase PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (315 aa)
gorGlutathione-disulfide reductase Gor. (456 aa)
mvhD2Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa)
fdhB2Formate dehydrogenase beta subunit FdhB2. (385 aa)
fdhA2Formate dehydrogenase alpha subunit FdhA2. (343 aa)
Abm4_0856Hypothetical protein. (520 aa)
hmgAhydroxymethylglutaryl-CoA reductase (NADPH) HmgA; Belongs to the HMG-CoA reductase family. (401 aa)
Abm4_0927Carboxymuconolactone decarboxylase family protein. (105 aa)
Abm4_09344Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (283 aa)
ehaQEnergy-converting hydrogenase A subunit Q EhaQ. (523 aa)
ehaPEnergy-converting hydrogenase A subunit P EhaP. (351 aa)
ehaOEnergy-converting hydrogenase A subunit O EhaO; Belongs to the complex I 49 kDa subunit family. (372 aa)
Abm4_0971Geranylgeranyl reductase family protein. (399 aa)
gltAGlutamate synthase alpha subunit GltA; Belongs to the glutamate synthase family. (497 aa)
gltBGlutamate synthase beta subunit GltB. (225 aa)
aksFIsohomocitrate dehydrogenase AksF. (337 aa)
Abm4_1002Alcohol dehydrogenase. (339 aa)
Abm4_1029Hypothetical protein. (408 aa)
Abm4_1093Nitroreductase family protein. (172 aa)
Abm4_1094NADPH-dependent FMN reductase. (185 aa)
Abm4_1113Nitroreductase family protein. (170 aa)
Abm4_1114Oxidoreductase aldo/keto reductase family. (277 aa)
Abm4_1130Oxidoreductase aldo/keto reductase family. (407 aa)
Abm4_1157Nitroreductase family protein. (175 aa)
hbd3-hydroxybutyryl-CoA dehydrogenase Hbd. (311 aa)
Abm4_1169Geranylgeranyl reductase family protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (396 aa)
Abm4_1178NADPH-dependent FMN reductase. (178 aa)
dfxDesulfoferrodoxin Dfx. (127 aa)
Abm4_12014Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (241 aa)
noxNADH oxidase Nox. (443 aa)
egsANAD(P)-dependent glycerol-1-phosphate dehydrogenase EgsA; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (347 aa)
fniIsopentenyl diphosphate delta-isomerase Fni; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (353 aa)
Abm4_12334Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (64 aa)
Abm4_12914Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (328 aa)
Abm4_12924Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (63 aa)
Abm4_1297Iron-containing alcohol dehydrogenase. (398 aa)
hdrB2CoB--CoM heterodisulfide reductase subunit B HdrB2. (294 aa)
hdrC2CoB--CoM heterodisulfide reductase subunit C HdrC2. (347 aa)
Abm4_1314Rubrerythrin. (181 aa)
iorBIndolepyruvate ferredoxin oxidoreductase beta subunit IorB. (198 aa)
iorAIndolepyruvate ferredoxin oxidoreductase alpha subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (634 aa)
sdhBSuccinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (497 aa)
dusA1tRNA-dihydrouridine synthase DusA1. (329 aa)
Abm4_1357Pyridoxamine 5'-phosphate oxidase family protein. (130 aa)
Abm4_1383Flavodoxin. (155 aa)
mer5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa)
rfbDdTDP-4-dehydrorhamnose reductase RfbD. (277 aa)
Abm4_1421Hypothetical protein. (279 aa)
porCPyruvate ferredoxin oxidoreductase gamma subunit PorC. (173 aa)
porDPyruvate ferredoxin oxidoreductase delta subunit PorD. (82 aa)
porAPyruvate ferredoxin oxidoreductase alpha subunit PorA. (384 aa)
porBPyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa)
porEPyruvate ferredoxin oxidoreductase-associated PorE. (164 aa)
porFPyruvate ferredoxin oxidoreductase-associated PorF. (144 aa)
Abm4_14484Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (58 aa)
Abm4_14554Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (244 aa)
Abm4_1462Carboxymuconolactone decarboxylase family protein. (251 aa)
Abm4_1463NADPH-dependent FMN reductase. (177 aa)
Abm4_1464NADPH-dependent FMN reductase. (178 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase Gap. (337 aa)
hemAglutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (412 aa)
cysGSiroheme synthase CysG. (223 aa)
dusA2tRNA-dihydrouridine synthase DusA2. (236 aa)
mvhBMethyl viologen-reducing hydrogenase beta subunit MvhB. (415 aa)
mvhAMethyl viologen-reducing hydrogenase alpha subunit MvhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (474 aa)
mvhGMethyl viologen-reducing hydrogenase gamma subunit MvhG. (309 aa)
mvhDMethyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa)
comCL-sulfolactate dehydrogenase ComC. (342 aa)
hcpHydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (439 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit PyrK. (265 aa)
pyrDDihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate. (303 aa)
ehbOEnergy-converting hydrogenase B subunit O EhbO. (334 aa)
ehbNEnergy-converting hydrogenase B subunit N EhbN. (378 aa)
ehbLEnergy-converting hydrogenase B subunit L EhbL. (167 aa)
ehbKEnergy-converting hydrogenase B subunit K EhbK. (469 aa)
ehbFEnergy-converting hydrogenase B subunit F EhbF. (497 aa)
nadX2L-aspartate dehydrogenase NadX2. (254 aa)
npdG2NADPH-dependent F420 reductase NpdG2. (224 aa)
Abm4_1628Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (498 aa)
Abm4_1629Iron-containing alcohol dehydrogenase. (393 aa)
frhB1Coenzyme F420 hydrogenase beta subunit FrhB1. (292 aa)
frhGCoenzyme F420 hydrogenase gamma subunit FrhG. (271 aa)
frhACoenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa)
Abm4_1671Oxidoreductase aldo/keto reductase family. (342 aa)
fprA2F420H2 oxidase FprA2. (411 aa)
Abm4_1681Rubrerythrin. (137 aa)
hdrA2CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa)
afpAArchaeoflavoprotein AfpA. (235 aa)
leuB3-isopropylmalate dehydrogenase LeuB. (329 aa)
hmdCoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase Hmd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (339 aa)
sdhASuccinate dehydrogenase/fumarate reductase flavoprotein subunit SdhA. (558 aa)
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
Abm4_0043NADPH-dependent FMN reductase. (200 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
Abm4_0088Flavin reductase domain-containing protein. (161 aa)
Abm4_0121Methanogenesis marker protein 13. (362 aa)
fdhAFormate dehydrogenase alpha subunit FdhA. (688 aa)
fdhBFormate dehydrogenase beta subunit FdhB. (411 aa)
fwdHTungsten formylmethanofuran dehydrogenase subunit H FwdH. (155 aa)
fwdFTungsten formylmethanofuran dehydrogenase subunit F FwdF. (367 aa)
fwdGTungsten formylmethanofuran dehydrogenase subunit G FwdG. (76 aa)
fwdDTungsten formylmethanofuran dehydrogenase subunit D FwdD. (188 aa)
fwdBTungsten formylmethanofuran dehydrogenase subunit B FwdB. (458 aa)
fwdCTungsten formylmethanofuran dehydrogenase subunit C FwdC. (288 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase NrdD. (772 aa)
Abm4_0170Oxidoreductase aldo/keto reductase family. (391 aa)
Abm4_02184Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (64 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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