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top6A top6A Abm4_1503 Abm4_1503 polB1 polB1 nop10 nop10 rps27e rps27e rpl44e rpl44e rpl21e rpl21e Abm4_0001 Abm4_0001 albA albA rps15 rps15 rps19e rps19e rpl39e rpl39e rpl31e rpl31e rplX rplX Abm4_0213 Abm4_0213 rps3ae rps3ae spt5 spt5 rpl11 rpl11 rpl1 rpl1 rpl10 rpl10 rpl12 rpl12 rpl30e rpl30e rps12 rps12 rps7 rps7 rps10 rps10 Abm4_0372 Abm4_0372 Abm4_0377 Abm4_0377 Abm4_0410 Abm4_0410 dnaG dnaG Abm4_0444 Abm4_0444 Abm4_0453 Abm4_0453 Abm4_0526 Abm4_0526 Abm4_0487 Abm4_0487 rps17e rps17e priB priB priA priA Abm4_0708 Abm4_0708 rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e rps6e rps6e Abm4_0716 Abm4_0716 rps24e rps24e rps27ae rps27ae rfcS rfcS rfcL rfcL rpl37e rpl37e Abm4_0848 Abm4_0848 mre11 mre11 rpl40e rpl40e Abm4_0915 Abm4_0915 rpl37ae rpl37ae Abm4_0921 Abm4_0921 Abm4_0926 Abm4_0926 rps8e rps8e polB2 polB2 rps2p rps2p rps9p rps9p rpl13 rpl13 rpl18e rpl18e rps11 rps11 rps4p rps4p rps13 rps13 Abm4_1248 Abm4_1248 rpl34e rpl34e rpl15 rpl15 rpl30 rpl30 rps5p rps5p rpl18 rpl18 rpl19e rpl19e Abm4_1259 Abm4_1259 rpl6p rpl6p rps8p rps8p rps14 rps14 rpl5p rpl5p rps4e rps4e rpl24 rpl24 rpl14 rpl14 rps17 rps17 rpl29 rpl29 rps3p rps3p rpl22 rpl22 rps19p rps19p rpl2p rpl2p rpl23 rpl23 rpl4p rpl4p rpl3p rpl3p Abm4_1278 Abm4_1278 Abm4_1426 Abm4_1426 Abm4_1472 Abm4_1472 top6B top6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (371 aa)
Abm4_1503Ribosomal protein L10e Rpl10e. (160 aa)
polB1DNA polymerase family B PolB1. (615 aa)
nop10H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (53 aa)
rps27eRibosomal protein S27e Rps27e. (59 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
rpl21eRibosomal protein L21e Rpl21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
Abm4_0001Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (385 aa)
albADNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (92 aa)
rps15Ribosomal protein S15P Rps15p. (132 aa)
rps19eRibosomal protein S19e Rps19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
rpl39eRibosomal protein L39e Rpl39e; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
rpl31eRibosomal protein L31e Rpl31e; Belongs to the ribosomal protein L31e family. (88 aa)
rplXRibosomal protein LX RplX. (74 aa)
Abm4_0213Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa)
rps3aeRibosomal protein S3Ae Rps3ae; Belongs to the eukaryotic ribosomal protein eS1 family. (191 aa)
spt5Ribosomal protein L24 family; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (160 aa)
rpl11Ribosomal protein L11P Rpl11p; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (161 aa)
rpl1Ribosomal protein L1P Rpl1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rpl10Acidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (336 aa)
rpl12Ribosomal protein L12P Rpl12p; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (100 aa)
rpl30eRibosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
rps12Ribosomal protein S12P Rps12p; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa)
rps7Ribosomal protein S7P Rps7p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (187 aa)
rps10Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
Abm4_0372ADP-ribosylglycohydrolase. (314 aa)
Abm4_0377Cdc6 family replication initiation protein Cdc6-3. (275 aa)
Abm4_0410Hypothetical protein; Belongs to the UPF0145 family. (113 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (427 aa)
Abm4_0444H/ACA RNA-protein complex component Gar1. (93 aa)
Abm4_0453Hypothetical protein; Belongs to the UPF0145 family. (107 aa)
Abm4_0526Archaeal histone. (66 aa)
Abm4_0487GTP-binding protein. (345 aa)
rps17eRibosomal protein S17e Rps17e; Belongs to the eukaryotic ribosomal protein eS17 family. (64 aa)
priBDNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (452 aa)
priADNA primase small subunit PriA; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (334 aa)
Abm4_0708Archaeal histone. (67 aa)
rpl7aeRibosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
rps28eRibosomal protein S28e Rps28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rps6eRibosomal protein S6e Rps6e; Belongs to the eukaryotic ribosomal protein eS6 family. (126 aa)
Abm4_0716Hypothetical protein. (128 aa)
rps24eRibosomal protein S24e Rps24e; Belongs to the eukaryotic ribosomal protein eS24 family. (103 aa)
rps27aeRibosomal protein S27ae Rps27ae; Belongs to the eukaryotic ribosomal protein eS31 family. (51 aa)
rfcSReplication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (315 aa)
rfcLReplication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (552 aa)
rpl37eRibosomal protein L37e Rpl37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (61 aa)
Abm4_0848Archaeal histone. (67 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (380 aa)
rpl40eRibosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
Abm4_0915Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (171 aa)
rpl37aeRibosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (87 aa)
Abm4_0921Exosome subunit. (233 aa)
Abm4_0926Ribosomal protein L15e Rpl15e. (184 aa)
rps8eRibosomal protein S8e Rps8e. (125 aa)
polB2DNA polymerase family B PolB2. (236 aa)
rps2pRibosomal protein S2P Rps2p; Belongs to the universal ribosomal protein uS2 family. (200 aa)
rps9pRibosomal protein S9P Rps9p; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rpl13Ribosomal protein L13P Rpl13p; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (140 aa)
rpl18eRibosomal protein L18e Rpl18e; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rps11Ribosomal protein S11P Rps11p; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
rps4pRibosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rps13Ribosomal protein S13P Rps13p; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (153 aa)
Abm4_1248Ribosomal protein L14e Rpl14e. (73 aa)
rpl34eRibosomal protein L34e Rpl34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
rpl15Ribosomal protein L15P Rpl15p; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (145 aa)
rpl30Ribosomal protein L30P Rpl30p. (152 aa)
rps5pRibosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (214 aa)
rpl18Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rpl19eRibosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa)
Abm4_1259Ribosomal protein L32e Rpl32e. (108 aa)
rpl6pRibosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rps8pRibosomal protein S8P Rps8p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rps14Ribosomal protein S14P Rps14p; Binds 16S rRNA, required for the assembly of 30S particles. (47 aa)
rpl5pRibosomal protein L5P Rpl5p; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (171 aa)
rps4eRibosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (241 aa)
rpl24Ribosomal protein L24P Rpl24p; Located at the polypeptide exit tunnel on the outside of the subunit. (116 aa)
rpl14Ribosomal protein L14P Rpl14p; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rps17Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (105 aa)
rpl29Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rps3pRibosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (254 aa)
rpl22Ribosomal protein L22P Rpl22p; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (154 aa)
rps19pRibosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rpl2pRibosomal protein L2P Rpl2p; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (241 aa)
rpl23Ribosomal protein L23P Rpl23p; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl4pRibosomal protein L4p Rpl4p; Forms part of the polypeptide exit tunnel. (254 aa)
rpl3pRibosomal protein L3P Rpl3p; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa)
Abm4_1278Hypothetical protein. (272 aa)
Abm4_1426ATPase. (282 aa)
Abm4_1472RNA-binding protein. (199 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (598 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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