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rpl37ae rpl37ae cbiX1 cbiX1 cbiX2 cbiX2 Abm4_0630 Abm4_0630 feoA feoA hisD hisD Abm4_0703 Abm4_0703 rpl24e rpl24e rpoE2 rpoE2 rps27ae rps27ae cofH cofH Abm4_0776 Abm4_0776 Abm4_0777 Abm4_0777 Abm4_0778 Abm4_0778 hisI hisI htpX htpX arfB arfB rpl37e rpl37e uvrA uvrA rad50 rad50 mre11 mre11 metE metE Abm4_0908 Abm4_0908 Abm4_0916 Abm4_0916 ribB ribB thrS thrS Abm4_0080 Abm4_0080 Abm4_0128 Abm4_0128 Abm4_0129 Abm4_0129 fwdC fwdC fwdE fwdE thiC1 thiC1 Abm4_0158 Abm4_0158 rnp4 rnp4 Abm4_0223 Abm4_0223 thiC2 thiC2 Abm4_0242 Abm4_0242 hypC hypC alaS alaS queC queC Abm4_0319 Abm4_0319 rpoB rpoB tfb tfb cab cab hypA hypA hypB hypB ileS ileS Abm4_1681 Abm4_1681 csl4 csl4 tfs2 tfs2 rpl44e rpl44e rps27e rps27e frhA frhA frhG frhG frhB1 frhB1 dnaJ dnaJ hypF hypF cobB cobB ehbN ehbN cofG cofG mptA mptA mtrA mtrA mvhA mvhA mvhB mvhB pyrC pyrC rnhB rnhB Abm4_1479 Abm4_1479 thi4 thi4 rnz rnz Abm4_1363 Abm4_1363 Abm4_1314 Abm4_1314 rps14 rps14 rnj rnj Abm4_1183 Abm4_1183 dfx dfx tfs1 tfs1 Abm4_1002 Abm4_1002 nikR nikR Abm4_0983 Abm4_0983 Abm4_0978 Abm4_0978 Abm4_0966 Abm4_0966 ehaO ehaO
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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rpl37aeRibosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (87 aa)
cbiX1Cobalamin biosynthesis protein CbiX1; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (152 aa)
cbiX2Cobalamin biosynthesis protein CbiX2. (307 aa)
Abm4_0630Rubredoxin. (54 aa)
feoAFerrous iron transport protein A FeoA. (79 aa)
hisDHistidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
Abm4_0703Iron-dependent repressor. (241 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rpoE2DNA-directed RNA polymerase subunit E'' RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (62 aa)
rps27aeRibosomal protein S27ae Rps27ae; Belongs to the eukaryotic ribosomal protein eS31 family. (51 aa)
cofHFO synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (374 aa)
Abm4_0776Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (53 aa)
Abm4_0777Rubredoxin. (44 aa)
Abm4_0778Ferritin-like domain-containing protein. (169 aa)
hisIphosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa)
htpXPeptidase M48 family; Belongs to the peptidase M48B family. (321 aa)
arfBCreatinine amidohydrolase ArfB; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy). (230 aa)
rpl37eRibosomal protein L37e Rpl37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (61 aa)
uvrAExcinuclease ABC A subunit UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (965 aa)
rad50DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (925 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (380 aa)
metEMethionine synthase MetE. (321 aa)
Abm4_0908Iron-dependent repressor. (213 aa)
Abm4_0916DNA-directed RNA polymerase subunit P RpoP. (43 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase RibB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (212 aa)
thrSthreonyl-tRNA synthetase ThrS; Belongs to the class-II aminoacyl-tRNA synthetase family. (611 aa)
Abm4_0080Universal archaeal protein Kae1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (549 aa)
Abm4_0128Copper ion-binding protein. (70 aa)
Abm4_0129Copper translocating P-type ATPase. (818 aa)
fwdCTungsten formylmethanofuran dehydrogenase subunit C FwdC. (288 aa)
fwdETungsten formylmethanofuran dehydrogenase subunit E FwdE. (190 aa)
thiC1Thiamine biosynthesis protein ThiC1; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa)
Abm4_0158CMP/dCMP deaminase. (157 aa)
rnp4Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa)
Abm4_0223Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (62 aa)
thiC2Thiamine biosynthesis protein ThiC2; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
Abm4_0242Hypothetical protein. (340 aa)
hypCHydrogenase assembly chaperone HypC. (89 aa)
alaSalanyl-tRNA synthetase AlaS; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (906 aa)
queCExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (226 aa)
Abm4_0319Hypothetical protein; Belongs to the LarC family. (406 aa)
rpoBDNA-directed RNA polymerase subunit B RpoB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1117 aa)
tfbTranscription initiation factor TFIIB Tfb; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (310 aa)
cabCarbonic anhydrase Cab. (176 aa)
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (124 aa)
hypBHydrogenase accessory protein HypB. (220 aa)
ileSisoleucyl-tRNA synthetase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1107 aa)
Abm4_1681Rubrerythrin. (137 aa)
csl4Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (189 aa)
tfs2Transcription factor S Tfs2; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
rps27eRibosomal protein S27e Rps27e. (59 aa)
frhACoenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa)
frhGCoenzyme F420 hydrogenase gamma subunit FrhG. (271 aa)
frhB1Coenzyme F420 hydrogenase beta subunit FrhB1. (292 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (381 aa)
hypFHydrogenase maturation factor HypF. (780 aa)
cobBNAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (245 aa)
ehbNEnergy-converting hydrogenase B subunit N EhbN. (378 aa)
cofGFO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (379 aa)
mptAGTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (311 aa)
mtrATetrahydromethanopterin S-methyltransferase subunit A MtrA; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa)
mvhAMethyl viologen-reducing hydrogenase alpha subunit MvhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (474 aa)
mvhBMethyl viologen-reducing hydrogenase beta subunit MvhB. (415 aa)
pyrCDihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (419 aa)
rnhBRibonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (207 aa)
Abm4_1479Endonuclease IV. (277 aa)
thi4Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (262 aa)
rnzRibonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (297 aa)
Abm4_1363ZPR1 zinc-finger domain-containing protein. (194 aa)
Abm4_1314Rubrerythrin. (181 aa)
rps14Ribosomal protein S14P Rps14p; Binds 16S rRNA, required for the assembly of 30S particles. (47 aa)
rnjRNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (451 aa)
Abm4_1183NifU-like FeS cluster assembly scaffold protein. (127 aa)
dfxDesulfoferrodoxin Dfx. (127 aa)
tfs1Transcription factor S Tfs1; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (106 aa)
Abm4_1002Alcohol dehydrogenase. (339 aa)
nikRNickel responsive transcriptional regulator NikR; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (147 aa)
Abm4_0983D-alanine-D-alanine ligase. (376 aa)
Abm4_0978Hypothetical protein. (134 aa)
Abm4_0966Hypothetical protein. (398 aa)
ehaOEnergy-converting hydrogenase A subunit O EhaO; Belongs to the complex I 49 kDa subunit family. (372 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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