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fumA2 fumA2 Abm4_0376 Abm4_0376 taw1 taw1 thiC2 thiC2 Abm4_0229 Abm4_0229 aksD aksD thiC1 thiC1 mobB mobB moaA moaA fdhB fdhB fdhA fdhA Abm4_0107 Abm4_0107 ilvD ilvD Abm4_0035 Abm4_0035 hcgA hcgA queE queE Abm4_1573 Abm4_1573 ehbM ehbM Abm4_1608 Abm4_1608 frhB1 frhB1 frhG frhG frhA frhA Abm4_1653 Abm4_1653 hdrA2 hdrA2 leuC leuC Abm4_1724 Abm4_1724 pyrK pyrK hcp hcp cofG cofG Abm4_1531 Abm4_1531 mvhD mvhD mvhG mvhG mvhB mvhB fumA4 fumA4 porB porB porD porD Abm4_1419 Abm4_1419 Abm4_1418 Abm4_1418 nadA nadA sdhB sdhB iorA iorA Abm4_1320 Abm4_1320 nifB nifB Abm4_1311 Abm4_1311 hdrC2 hdrC2 Abm4_1294 Abm4_1294 rpoD rpoD Abm4_1189 Abm4_1189 nifS nifS Abm4_1183 Abm4_1183 Abm4_1140 Abm4_1140 Abm4_1129 Abm4_1129 Abm4_1065 Abm4_1065 gltA gltA ehaN ehaN Abm4_0866 Abm4_0866 fdhA2 fdhA2 fdhB2 fdhB2 mvhD2 mvhD2 parA parA frhB2 frhB2 cofH cofH Abm4_0759 Abm4_0759 hdrB3 hdrB3 Abm4_0742 Abm4_0742 Abm4_0733 Abm4_0733 purF purF hdrA1 hdrA1 hdrC1 hdrC1 Abm4_0530 Abm4_0530 priB priB Abm4_0525 Abm4_0525 Abm4_0510 Abm4_0510
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fumA2Fumarate hydratase FumA2. (293 aa)
Abm4_0376Nitrite and sulphite reductase 4Fe-4S region. (690 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (306 aa)
thiC2Thiamine biosynthesis protein ThiC2; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
Abm4_0229Anaerobic ribonucleoside-triphosphate reductase activating protein. (236 aa)
aksDHomoaconitase large subunit AksD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa)
thiC1Thiamine biosynthesis protein ThiC1; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa)
mobBMolybdopterin-guanine dinucleotide biosynthesis protein B MobB. (234 aa)
moaAMolybdopterin cofactor biosynthesis protein A MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (310 aa)
fdhBFormate dehydrogenase beta subunit FdhB. (411 aa)
fdhAFormate dehydrogenase alpha subunit FdhA. (688 aa)
Abm4_0107CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (164 aa)
ilvDDihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (551 aa)
Abm4_0035Radical SAM domain-containing protein. (371 aa)
hcgABioB family protein HcgA. (333 aa)
queERadical SAM domain-containing protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (233 aa)
Abm4_1573CRISPR-associated protein Cas4. (276 aa)
ehbMEnergy-converting hydrogenase B subunit M EhbM. (148 aa)
Abm4_1608Radical SAM domain-containing protein. (333 aa)
frhB1Coenzyme F420 hydrogenase beta subunit FrhB1. (292 aa)
frhGCoenzyme F420 hydrogenase gamma subunit FrhG. (271 aa)
frhACoenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa)
Abm4_1653Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (336 aa)
hdrA2CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa)
leuC3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa)
Abm4_1724Glycyl-radical enzyme activating protein family. (335 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit PyrK. (265 aa)
hcpHydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (439 aa)
cofGFO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (379 aa)
Abm4_1531Methanogenesis marker protein 10. (423 aa)
mvhDMethyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa)
mvhGMethyl viologen-reducing hydrogenase gamma subunit MvhG. (309 aa)
mvhBMethyl viologen-reducing hydrogenase beta subunit MvhB. (415 aa)
fumA4Fumarate hydratase FumA4. (280 aa)
porBPyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa)
porDPyruvate ferredoxin oxidoreductase delta subunit PorD. (82 aa)
Abm4_1419Radical SAM domain-containing protein. (364 aa)
Abm4_1418Radical SAM domain-containing protein. (304 aa)
nadAQuinolinate synthetase A protein NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
sdhBSuccinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (497 aa)
iorAIndolepyruvate ferredoxin oxidoreductase alpha subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (634 aa)
Abm4_1320Methanogenesis marker protein 15. (415 aa)
nifBNitrogenase cofactor biosynthesis protein NifB. (307 aa)
Abm4_1311Radical SAM domain-containing protein. (480 aa)
hdrC2CoB--CoM heterodisulfide reductase subunit C HdrC2. (347 aa)
Abm4_1294Radical SAM domain-containing protein. (523 aa)
rpoDDNA-directed RNA polymerase subunit D RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (267 aa)
Abm4_1189Radical SAM domain-containing protein. (504 aa)
nifSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (401 aa)
Abm4_1183NifU-like FeS cluster assembly scaffold protein. (127 aa)
Abm4_1140CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (233 aa)
Abm4_1129Radical SAM domain-containing protein. (492 aa)
Abm4_1065Radical SAM domain-containing protein. (298 aa)
gltAGlutamate synthase alpha subunit GltA; Belongs to the glutamate synthase family. (497 aa)
ehaNEnergy-converting hydrogenase A subunit N EhaN. (158 aa)
Abm4_0866Hypothetical protein. (401 aa)
fdhA2Formate dehydrogenase alpha subunit FdhA2. (343 aa)
fdhB2Formate dehydrogenase beta subunit FdhB2. (385 aa)
mvhD2Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa)
parAChromosome partitioning ATPase ParA; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (288 aa)
frhB2Coenzyme F420 hydrogenase beta subunit FrhB2. (360 aa)
cofHFO synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (374 aa)
Abm4_0759Iron-sulfur cluster-binding protein. (404 aa)
hdrB3CoB--CoM heterodisulfide reductase subunit B HdrB3. (232 aa)
Abm4_0742Radical SAM domain-containing protein. (376 aa)
Abm4_07334Fe-4S iron sulfur cluster binding protein NifH/frxC family; Belongs to the NifH/BchL/ChlL family. (267 aa)
purFAmidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa)
hdrA1CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa)
hdrC1CoB--CoM heterodisulfide reductase subunit C HdrC1. (204 aa)
Abm4_0530Histone acetyltransferase ELP3 family. (570 aa)
priBDNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (452 aa)
Abm4_0525MiaB-like tRNA modifying enzyme. (429 aa)
Abm4_0510Molybdenum cofactor biosynthesis-related protein. (509 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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