(8 nodes) 2 iron, 2 sulfur cluster binding network (Methanobrevibacter sp. AbM4)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hcgA	BioB family protein HcgA. (333 aa)
	ilvD	Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (551 aa)
	hdrA1	CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa)
	mvhD2	Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa)
	nifS	Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (401 aa)
	sdhB	Succinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (497 aa)
	mvhD	Methyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa)
	pyrK	Dihydroorotate dehydrogenase electron transfer subunit PyrK. (265 aa)

Your Current Organism:

Methanobrevibacter sp. AbM4

NCBI taxonomy Id: 224719
Other names: M. sp. AbM4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hdrA1	mvhD	Abm4_0695	Abm4_1512	CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).	Methyl viologen-reducing hydrogenase delta subunit MvhD.	0.897
hdrA1	mvhD2	Abm4_0695	Abm4_0853	CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	0.892
mvhD	hdrA1	Abm4_1512	Abm4_0695	Methyl viologen-reducing hydrogenase delta subunit MvhD.	CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).	0.897
mvhD	mvhD2	Abm4_1512	Abm4_0853	Methyl viologen-reducing hydrogenase delta subunit MvhD.	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	0.902
mvhD	pyrK	Abm4_1512	Abm4_1558	Methyl viologen-reducing hydrogenase delta subunit MvhD.	Dihydroorotate dehydrogenase electron transfer subunit PyrK.	0.872
mvhD2	hdrA1	Abm4_0853	Abm4_0695	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).	0.892
mvhD2	mvhD	Abm4_0853	Abm4_1512	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	Methyl viologen-reducing hydrogenase delta subunit MvhD.	0.902
mvhD2	pyrK	Abm4_0853	Abm4_1558	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	Dihydroorotate dehydrogenase electron transfer subunit PyrK.	0.791
pyrK	mvhD	Abm4_1558	Abm4_1512	Dihydroorotate dehydrogenase electron transfer subunit PyrK.	Methyl viologen-reducing hydrogenase delta subunit MvhD.	0.872
pyrK	mvhD2	Abm4_1558	Abm4_0853	Dihydroorotate dehydrogenase electron transfer subunit PyrK.	Methyl viologen-reducing hydrogenase delta subunit MvhD2.	0.791