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| | thgL | tRNA(His) guanylyltransferase ThgL. (282 aa) |
| | tiaS | DNA-binding protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (405 aa) |
| | ahaH | A1A0 archaeal ATP synthase subunit H AhaH. (104 aa) |
| | Abm4_0434 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (267 aa) |
| | Abm4_0435 | Hypothetical protein. (134 aa) |
| | dnaG | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (427 aa) |
| | Abm4_0526 | Archaeal histone. (66 aa) |
| | Abm4_0525 | MiaB-like tRNA modifying enzyme. (429 aa) |
| | hsdS5 | Type I restriction-modification system S subunit HsdS5. (340 aa) |
| | Abm4_0523 | Phage integrase family protein. (347 aa) |
| | hsdS4 | Type I restriction-modification system S subunit HsdS4. (115 aa) |
| | hsdS3 | Type I restriction-modification system S subunit HsdS3. (387 aa) |
| | hsdM2 | Type I restriction-modification system M subunit HsdM2. (511 aa) |
| | hsdR2 | Type I restriction-modification system R subunit HsdR2. (912 aa) |
| | truA | tRNA pseudouridine synthase A TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (296 aa) |
| | Abm4_0485 | Transposase. (206 aa) |
| | tfb | Transcription initiation factor TFIIB Tfb; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (310 aa) |
| | Abm4_0444 | H/ACA RNA-protein complex component Gar1. (93 aa) |
| | Abm4_1201 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (241 aa) |
| | proS | prolyl-tRNA synthetase ProS; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (469 aa) |
| | gltX | glutamyl-tRNA synthetase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (557 aa) |
| | rnj | RNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (451 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K RpoK; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (60 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N RpoN. (56 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (267 aa) |
| | cbf5p | H/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa) |
| | rnp1 | Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (93 aa) |
| | Abm4_1310 | Archaeosine tRNA-ribosyltransferase family protein. (249 aa) |
| | Abm4_1316 | Met-10+ like-protein. (361 aa) |
| | Abm4_1326 | Hypothetical protein. (167 aa) |
| | Abm4_1341 | RNA methyltransferase TrmH family. (303 aa) |
| | glyS | glycyl-tRNA synthetase GlyS. (568 aa) |
| | Abm4_1345 | Hypothetical protein. (584 aa) |
| | dusA1 | tRNA-dihydrouridine synthase DusA1. (329 aa) |
| | rnz | Ribonuclease Z Rnz; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (297 aa) |
| | nucS | Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (260 aa) |
| | Abm4_1378 | DEAD/DEAH box helicase domain-containing protein. (867 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | rrmJ | Ribosomal RNA large subunit methyltransferase J RrmJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (202 aa) |
| | mcm | Replicative DNA helicase Mcm; Belongs to the MCM family. (666 aa) |
| | tyrS | tyrosyl-tRNA synthetase TyrS; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (320 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit XseA. (462 aa) |
| | xseB | Exodeoxyribonuclease VII small subunit XseB. (89 aa) |
| | mutS2 | DNA mismatch repair ATPase MutS family; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (641 aa) |
| | Abm4_1418 | Radical SAM domain-containing protein. (304 aa) |
| | Abm4_1419 | Radical SAM domain-containing protein. (364 aa) |
| | Abm4_1424 | PP-loop family protein. (310 aa) |
| | Abm4_1455 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (244 aa) |
| | Abm4_1472 | RNA-binding protein. (199 aa) |
| | top6B | DNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (598 aa) |
| | top6A | DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (371 aa) |
| | Abm4_1479 | Endonuclease IV. (277 aa) |
| | dusA2 | tRNA-dihydrouridine synthase DusA2. (236 aa) |
| | rnhB | Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (207 aa) |
| | Abm4_1541 | PP-loop family protein. (285 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase Trm1; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (398 aa) |
| | taw2 | Met-10+ like-protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (251 aa) |
| | Abm4_1550 | Zinc-dependent ribonuclease. (635 aa) |
| | polB1 | DNA polymerase family B PolB1. (615 aa) |
| | flpA | Fibrillarin FlpA; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (216 aa) |
| | Abm4_1573 | CRISPR-associated protein Cas4. (276 aa) |
| | hjc | Archaeal Holliday junction resolvase Hjc; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (136 aa) |
| | dnaJ | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (381 aa) |
| | Abm4_1639 | Hypothetical protein. (399 aa) |
| | nop10 | H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (53 aa) |
| | pcn | DNA polymerase sliding clamp subunit PCNA family Pcn; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (244 aa) |
| | tfs2 | Transcription factor S Tfs2; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L RpoL; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | csl4 | Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (189 aa) |
| | pus10 | Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (409 aa) |
| | rpoF | DNA-directed RNA polymerase subunit F RpoF. (110 aa) |
| | ksgA | Dimethyladenosine transferase KsgA; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (287 aa) |
| | ogg | 8-oxoguanine DNA glycosylase Ogg. (326 aa) |
| | ileS | isoleucyl-tRNA synthetase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1107 aa) |
| | radA | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (311 aa) |
| | rpaI | Replication factor A RpaI. (789 aa) |
| | Abm4_1715 | Methanogenesis marker protein 11. (310 aa) |
| | Abm4_1716 | Transposase. (229 aa) |
| | polB | DNA polymerase small subunit DP1 PolD1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (605 aa) |
| | Abm4_0530 | Histone acetyltransferase ELP3 family. (570 aa) |
| | hel308 | DEAD/DEAH box helicase domain-containing protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (694 aa) |
| | Abm4_0546 | UvrD/REP family DNA helicase. (753 aa) |
| | Abm4_0612 | Hypothetical protein. (136 aa) |
| | Abm4_0641 | Hypothetical protein. (161 aa) |
| | metG | methionyl-tRNA synthetase MetG; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (671 aa) |
| | priB | DNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (452 aa) |
| | priA | DNA primase small subunit PriA; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (334 aa) |
| | cca | tRNA nucleotidyltransferase Cca; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (461 aa) |
| | Abm4_0659 | PHP domain-containing protein. (220 aa) |
| | Abm4_0675 | Hydrolase TatD family. (253 aa) |
| | aspS | aspartyl-tRNA synthetase AspS; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (439 aa) |
| | endA | tRNA intron endonuclease EndA. (171 aa) |
| | trpS | tryptophanyl-tRNA synthetase TrpS; Catalyzes the attachment of tryptophan to tRNA(Trp). (363 aa) |
| | Abm4_0708 | Archaeal histone. (67 aa) |
| | rpl7ae | Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa) |
| | Abm4_0716 | Hypothetical protein. (128 aa) |
| | rpoE1 | DNA-directed RNA polymerase subunit E' RpoE1. (185 aa) |
| | Abm4_0734 | Hypothetical protein. (148 aa) |
| | Abm4_0761 | YbaK family protein. (159 aa) |
| | Abm4_0768 | Hypothetical protein. (164 aa) |
| | rfcS | Replication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (315 aa) |
| | rfcL | Replication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (552 aa) |
| | hisS | histidyl-tRNA synthetase HisS; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | Abm4_0786 | Xylose isomerase-like TIM barrel domain-containing protein. (249 aa) |
| | Abm4_0798 | LSM domain-containing protein; Belongs to the snRNP Sm proteins family. (77 aa) |
| | rnc | Ribonuclease III Rnc. (222 aa) |
| | uvrC | Excinuclease ABC C subunit UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (589 aa) |
| | ogt | 6-O-methylguanine DNA methyltransferase Ogt. (206 aa) |
| | Abm4_0839 | Hydrolase TatD family. (261 aa) |
| | Abm4_0846 | Archaeal ATPase. (388 aa) |
| | Abm4_0848 | Archaeal histone. (67 aa) |
| | uvrA | Excinuclease ABC A subunit UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (965 aa) |
| | uvrB | Excinuclease ABC B subunit UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] (651 aa) |
| | Abm4_0863 | ATP-dependent DNA helicase UvrD/REP family. (812 aa) |
| | Abm4_0865 | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (881 aa) |
| | Abm4_0866 | Hypothetical protein. (401 aa) |
| | rad50 | DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (925 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta PheT. (552 aa) |
| | valS | valyl-tRNA synthetase ValS; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (909 aa) |
| | nth | Endonuclease III Nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa) |
| | cysS | cysteinyl-tRNA synthetase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. (487 aa) |
| | Abm4_1179 | Archaea-specific RecJ-like exonuclease. (741 aa) |
| | Abm4_1176 | Endonuclease III-related protein. (243 aa) |
| | Abm4_1167 | DNA-3-methyladenine glycosylase I. (189 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha subunit PheS; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (520 aa) |
| | xth | Exodeoxyribonuclease III Xth. (257 aa) |
| | polB2 | DNA polymerase family B PolB2. (236 aa) |
| | Abm4_1141 | Staphylococcal nuclease domain-containing protein. (270 aa) |
| | Abm4_1140 | CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (233 aa) |
| | recJ2 | ssDNA exonuclease RecJ2. (476 aa) |
| | Abm4_1121 | Hypothetical protein. (233 aa) |
| | serS | seryl-tRNA synthetase SerS. (425 aa) |
| | Abm4_0021 | Staphylococcal nuclease domain-containing protein. (168 aa) |
| | Abm4_0001 | Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (385 aa) |
| | mre11 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (380 aa) |
| | Abm4_0882 | NurA domain-containing protein. (306 aa) |
| | Abm4_0885 | Hypothetical protein; Probable pre-rRNA processing protein involved in ribosome biogenesis; Belongs to the TSR3 family. (172 aa) |
| | Abm4_0914 | Hypothetical protein. (89 aa) |
| | Abm4_0915 | Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (171 aa) |
| | Abm4_0916 | DNA-directed RNA polymerase subunit P RpoP. (43 aa) |
| | rrp42 | Exosome complex RNA-binding protein Rrp42; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (263 aa) |
| | rrp41 | Exosome complex exonuclease Rrp41. (243 aa) |
| | rrp4 | Exosome complex RNA-binding protein Rrp4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (334 aa) |
| | rnp2 | Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa) |
| | rnp3 | Ribonuclease P subunit P30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (244 aa) |
| | Abm4_0966 | Hypothetical protein. (398 aa) |
| | Abm4_0968 | Hypothetical protein. (169 aa) |
| | Abm4_0970 | RNA methylase. (343 aa) |
| | Abm4_1004 | Archaeal ATPase. (400 aa) |
| | Abm4_1017 | Type II restriction endonuclease; Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1; Belongs to the type II restriction enzyme DpnII family. (295 aa) |
| | Abm4_1018 | Type II DNA modification methylase. (309 aa) |
| | tgtA | Archaeosine tRNA-ribosyltransferase TgtA; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (659 aa) |
| | tfs1 | Transcription factor S Tfs1; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (106 aa) |
| | Abm4_1029 | Hypothetical protein. (408 aa) |
| | Abm4_1030 | Hydrolase HAD superfamily. (214 aa) |
| | Abm4_1041 | Hydrolase HAD superfamily. (204 aa) |
| | Abm4_1045 | Hydrolase HAD superfamily. (212 aa) |
| | Abm4_1050 | RNA-metabolising metallo-beta-lactamase. (523 aa) |
| | Abm4_1065 | Radical SAM domain-containing protein. (298 aa) |
| | cas2-2 | CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa) |
| | cas1-2 | CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (334 aa) |
| | Abm4_1111 | Restriction enzyme modulator protein. (340 aa) |
| | topA | DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] (736 aa) |
| | rnp4 | Ribonuclease P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa) |
| | Abm4_0195 | RNA-binding protein. (87 aa) |
| | Abm4_0213 | Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa) |
| | Abm4_0215 | Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. (154 aa) |
| | rtcB | Hypothetical protein; Belongs to the RtcB family. (482 aa) |
| | dnlI | ATP-dependent DNA ligase DnlI; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (550 aa) |
| | pelA | Cell division protein pelota PelA; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (353 aa) |
| | Abm4_0249 | PUA domain-containing protein. (304 aa) |
| | Abm4_0250 | HD domain-containing protein. (164 aa) |
| | tfe | Transcription initiation factor TFIIE alpha subunit Tfe; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabili [...] (151 aa) |
| | alaS | alanyl-tRNA synthetase AlaS; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (906 aa) |
| | tbp | TATA-box binding protein Tbp; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (181 aa) |
| | fen | Flap endonuclease Fen; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] (327 aa) |
| | lysS | lysyl-tRNA synthetase LysS; Belongs to the class-I aminoacyl-tRNA synthetase family. (528 aa) |
| | nrdD | Anaerobic ribonucleoside-triphosphate reductase NrdD. (772 aa) |
| | polD2 | DNA polymerase large subunit DP2 PolD2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1121 aa) |
| | truD | tRNA pseudouridine synthase D TruD; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (427 aa) |
| | leuS | leucyl-tRNA synthetase LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. (955 aa) |
| | Abm4_0110 | CRISPR-associated protein Cas7. (323 aa) |
| | Abm4_0107 | CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (164 aa) |
| | cas1 | CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (322 aa) |
| | cas2 | CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (87 aa) |
| | xerC | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (330 aa) |
| | Abm4_0099 | tRNA(1-methyladenosine) methyltransferase. (243 aa) |
| | Abm4_0098 | Hef nuclease. (788 aa) |
| | Abm4_0096 | Type II DNA modification methylase. (375 aa) |
| | Abm4_0085 | Site-specific DNA-methyltransferase. (277 aa) |
| | recJ1 | ssDNA exonuclease RecJ1. (435 aa) |
| | Abm4_0080 | Universal archaeal protein Kae1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (549 aa) |
| | hsdR1 | Type I restriction-modification system R subunit HsdR1. (960 aa) |
| | hsdS1 | Type I restriction-modification system S subunit HsdS1. (411 aa) |
| | hsdM1 | Type I restriction-modification system M subunit HsdM1. (669 aa) |
| | Abm4_0068 | Type II restriction endonuclease. (360 aa) |
| | Abm4_0065 | LSM domain-containing protein. (67 aa) |
| | argS | arginyl-tRNA synthetase ArgS; Belongs to the class-I aminoacyl-tRNA synthetase family. (574 aa) |
| | thrS | threonyl-tRNA synthetase ThrS; Belongs to the class-II aminoacyl-tRNA synthetase family. (611 aa) |
| | Abm4_0035 | Radical SAM domain-containing protein. (371 aa) |
| | Abm4_0031 | PHP domain-containing protein. (219 aa) |
| | Abm4_0023 | Xylose isomerase-like TIM barrel domain-containing protein. (250 aa) |
| | thiI | Thiamine biosynthesis ATP pyrophosphatase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa) |
| | Abm4_0269 | Sua5/YciO/YrdC/YwlC family translation factor. (196 aa) |
| | Abm4_0278 | Hypothetical protein. (237 aa) |
| | radB | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (268 aa) |
| | Abm4_0314 | Hypothetical protein. (130 aa) |
| | Abm4_0323 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (181 aa) |
| | taw1 | tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (306 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H RpoH; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (81 aa) |
| | rpoB | DNA-directed RNA polymerase subunit B RpoB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1117 aa) |
| | rpoA1 | DNA-directed RNA polymerase subunit A' RpoA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (869 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'' RpoA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (423 aa) |
| | nusA | Transcription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family. (143 aa) |
| | Abm4_0377 | Cdc6 family replication initiation protein Cdc6-3. (275 aa) |
| | Abm4_0387 | Hypothetical protein. (246 aa) |
| | Abm4_0388 | Hypothetical protein. (417 aa) |
| | Abm4_0389 | DEAD/DEAH box helicase domain-containing protein. (725 aa) |
| | Abm4_0404 | tRNA binding domain-containing protein. (241 aa) |
