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adk adk pgk2 pgk2 Abm4_1362 Abm4_1362 Abm4_1378 Abm4_1378 mcm mcm tmk tmk mutS2 mutS2 Abm4_1426 Abm4_1426 pstB pstB Abm4_1456 Abm4_1456 Abm4_1480 Abm4_1480 atwA atwA sufC sufC srp54 srp54 Abm4_1676 Abm4_1676 Abm4_1700 Abm4_1700 radA radA Abm4_0001 Abm4_0001 Abm4_0018 Abm4_0018 Abm4_0026 Abm4_0026 minD minD cbiA cbiA hsdR1 hsdR1 Abm4_0084 Abm4_0084 Abm4_0098 Abm4_0098 Abm4_0100 Abm4_0100 Abm4_0108 Abm4_0108 Abm4_0116 Abm4_0116 Abm4_0120 Abm4_0120 mobB mobB Abm4_0146 Abm4_0146 Abm4_0190 Abm4_0190 Abm4_0191 Abm4_0191 Abm4_0192 Abm4_0192 Abm4_0193 Abm4_0193 ftsY ftsY Abm4_0213 Abm4_0213 Abm4_0236 Abm4_0236 Abm4_0264 Abm4_0264 proV proV gspE gspE radB radB modC modC fusA fusA tuf tuf Abm4_0377 Abm4_0377 Abm4_0388 Abm4_0388 Abm4_0389 Abm4_0389 ahaA ahaA ahaB ahaB Abm4_0476 Abm4_0476 Abm4_0477 Abm4_0477 Abm4_0487 Abm4_0487 hsdR2 hsdR2 hel308 hel308 Abm4_0546 Abm4_0546 cbiP cbiP Abm4_0598 Abm4_0598 hypB hypB feoB1 feoB1 Abm4_0666 Abm4_0666 infB infB eif2g eif2g Abm4_0733 Abm4_0733 cbiO cbiO Abm4_0774 Abm4_0774 rfcS rfcS rfcL rfcL Abm4_0785 Abm4_0785 Abm4_0792 Abm4_0792 coaE coaE pyrG pyrG Abm4_0824 Abm4_0824 parA parA Abm4_0846 Abm4_0846 uvrA uvrA uvrB uvrB Abm4_0863 Abm4_0863 Abm4_0877 Abm4_0877 rad50 rad50 Abm4_0881 Abm4_0881 feoB2 feoB2 pan pan Abm4_1004 Abm4_1004 Abm4_1031 Abm4_1031 Abm4_1110 Abm4_1110 Abm4_1139 Abm4_1139 Abm4_1154 Abm4_1154 btcA btcA purA purA cmk cmk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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adkAdenylate kinase Adk; Belongs to the archaeal adenylate kinase family. (185 aa)
pgk22-phosphoglycerate kinase Pgk2. (303 aa)
Abm4_1362Hypothetical protein. (349 aa)
Abm4_1378DEAD/DEAH box helicase domain-containing protein. (867 aa)
mcmReplicative DNA helicase Mcm; Belongs to the MCM family. (666 aa)
tmkThymidylate kinase Tmk. (197 aa)
mutS2DNA mismatch repair ATPase MutS family; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (641 aa)
Abm4_1426ATPase. (282 aa)
pstBPhosphate ABC transporter ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (251 aa)
Abm4_1456ATPase RIL. (591 aa)
Abm4_1480ATPase; Belongs to the AAA ATPase family. (375 aa)
atwAMethyl-coenzyme M reductase component A2 AtwA. (536 aa)
sufCFeS assembly ATPase SufC. (251 aa)
srp54Signal recognition particle SRP54 protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (446 aa)
Abm4_1676ATP-dependent DNA helicase. (621 aa)
Abm4_1700Polysaccharide ABC transporter ATP-binding protein. (393 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (311 aa)
Abm4_0001Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (385 aa)
Abm4_0018Cobyrinic acid a,c-diamide synthase-related protein. (507 aa)
Abm4_0026ABC transporter ATP-binding protein. (365 aa)
minDCell division ATPase MinD. (258 aa)
cbiACobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (468 aa)
hsdR1Type I restriction-modification system R subunit HsdR1. (960 aa)
Abm4_0084Type III restriction protein restriction subunit. (888 aa)
Abm4_0098Hef nuclease. (788 aa)
Abm4_0100ABC transporter ATP-binding protein. (239 aa)
Abm4_0108CRISPR-associated helicase Cas3. (948 aa)
Abm4_0116Anion-transporting ATPase. (336 aa)
Abm4_0120Translation-associated GTPase. (395 aa)
mobBMolybdopterin-guanine dinucleotide biosynthesis protein B MobB. (234 aa)
Abm4_0146ABC transporter ATP-binding protein. (260 aa)
Abm4_0190ABC transporter ATP-binding protein. (322 aa)
Abm4_0191ABC transporter ATP-binding protein. (204 aa)
Abm4_0192GTP-binding protein. (369 aa)
Abm4_0193Hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (198 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (506 aa)
Abm4_0213Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa)
Abm4_0236AAA family ATPase CDC48 subfamily. (738 aa)
Abm4_0264Glycine betaine/L-proline ABC transporter ATP-binding protein. (285 aa)
proVGlycine betaine/L-proline ABC transporter ATP-binding protein. (279 aa)
gspEType II secretion system protein E GspE. (608 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (268 aa)
modCMolybdate ABC transporter ATP-binding protein ModC. (346 aa)
fusATranslation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (730 aa)
tufTranslation elongation factor aEF-1 alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (413 aa)
Abm4_0377Cdc6 family replication initiation protein Cdc6-3. (275 aa)
Abm4_0388Hypothetical protein. (417 aa)
Abm4_0389DEAD/DEAH box helicase domain-containing protein. (725 aa)
ahaAA1A0 archaeal ATP synthase subunit A AhaA; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (584 aa)
ahaBA1A0 archaeal ATP synthase subunit B AhaB; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (461 aa)
Abm4_0476ABC transporter ATP-binding protein. (203 aa)
Abm4_0477ABC transporter ATP-binding protein. (316 aa)
Abm4_0487GTP-binding protein. (345 aa)
hsdR2Type I restriction-modification system R subunit HsdR2. (912 aa)
hel308DEAD/DEAH box helicase domain-containing protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (694 aa)
Abm4_0546UvrD/REP family DNA helicase. (753 aa)
cbiPCobyric acid synthase CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (525 aa)
Abm4_0598ATP-dependent protease S16 family; Belongs to the peptidase S16 family. (701 aa)
hypBHydrogenase accessory protein HypB. (220 aa)
feoB1Ferrous iron transport protein B FeoB1. (665 aa)
Abm4_0666ATPase. (410 aa)
infBTranslation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (595 aa)
eif2gTranslation initiation factor aIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa)
Abm4_07334Fe-4S iron sulfur cluster binding protein NifH/frxC family; Belongs to the NifH/BchL/ChlL family. (267 aa)
cbiOCobalt ABC transporter ATP-binding protein CbiO; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (248 aa)
Abm4_0774Methyl-coenzyme M reductase component A2-like protein. (574 aa)
rfcSReplication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (315 aa)
rfcLReplication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (552 aa)
Abm4_0785PIN domain-containing protein. (622 aa)
Abm4_0792DEAD/DEAH box helicase domain-containing protein. (1056 aa)
coaEdephospho-CoA kinase CoaE. (180 aa)
pyrGCTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa)
Abm4_0824DNA helicase. (2252 aa)
parAChromosome partitioning ATPase ParA; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (288 aa)
Abm4_0846Archaeal ATPase. (388 aa)
uvrAExcinuclease ABC A subunit UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (965 aa)
uvrBExcinuclease ABC B subunit UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] (651 aa)
Abm4_0863ATP-dependent DNA helicase UvrD/REP family. (812 aa)
Abm4_0877DEAD/DEAH box helicase domain-containing protein. (900 aa)
rad50DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (925 aa)
Abm4_0881ATPase. (506 aa)
feoB2Ferrous iron transport protein B FeoB2. (664 aa)
panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (414 aa)
Abm4_1004Archaeal ATPase. (400 aa)
Abm4_1031Helicase. (973 aa)
Abm4_1110Hypothetical protein. (365 aa)
Abm4_1139DEAD/DEAH box helicase domain-containing protein; Belongs to the DEAD box helicase family. (432 aa)
Abm4_1154Amino acid ABC transporter ATP-binding protein. (227 aa)
btcABicarbonate ABC transporter ATP-binding protein BtcA. (243 aa)
purAAdenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (340 aa)
cmkCytidylate kinase Cmk. (172 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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