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hmd hmd mtd mtd fae-hps fae-hps fdhA fdhA fdhB fdhB fwdH fwdH fwdF fwdF fwdG fwdG fwdD fwdD fwdB fwdB fwdA fwdA fwdC fwdC fwdE fwdE Abm4_0150 Abm4_0150 aksD aksD aksA aksA serB serB apgM apgM fbp fbp serA serA Abm4_0441 Abm4_0441 Abm4_0504 Abm4_0504 Abm4_0505 Abm4_0505 aksE aksE aroA-2 aroA-2 comA comA hdrC1 hdrC1 hdrB1 hdrB1 hdrA1 hdrA1 comE comE comD comD mfnB mfnB cofH cofH Abm4_0774 Abm4_0774 Abm4_0809 Abm4_0809 frhB2 frhB2 mvhD2 mvhD2 fdhB2 fdhB2 fdhA2 fdhA2 ftr1 ftr1 acsA acsA gltA gltA gltB gltB Abm4_0996 Abm4_0996 aksF aksF mch mch cofC cofC eno eno Abm4_1291 Abm4_1291 hdrB2 hdrB2 hdrC2 hdrC2 Abm4_1390 Abm4_1390 mer mer porC porC porD porD porA porA porB porB porE porE porF porF Abm4_1458 Abm4_1458 atwA atwA cofD cofD cofE2 cofE2 mfnA mfnA ppsA ppsA mvhA mvhA mvhG mvhG mvhD mvhD mtrH mtrH mtrG mtrG mtrF mtrF mtrA mtrA mtrB mtrB mtrC mtrC mtrD mtrD mtrE mtrE mcrA mcrA mcrG mcrG mcrC mcrC mcrD mcrD mcrB mcrB comB comB cofG cofG comC comC ftr2 ftr2 frhB1 frhB1 frhG frhG frhD frhD frhA frhA glyA glyA hdrA2 hdrA2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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hmdCoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase Hmd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (339 aa)
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
fae-hpsBifunctional formaldehyde-activating enzyme/3- hexulose-6-phosphate synthase Fae/Hps; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (407 aa)
fdhAFormate dehydrogenase alpha subunit FdhA. (688 aa)
fdhBFormate dehydrogenase beta subunit FdhB. (411 aa)
fwdHTungsten formylmethanofuran dehydrogenase subunit H FwdH. (155 aa)
fwdFTungsten formylmethanofuran dehydrogenase subunit F FwdF. (367 aa)
fwdGTungsten formylmethanofuran dehydrogenase subunit G FwdG. (76 aa)
fwdDTungsten formylmethanofuran dehydrogenase subunit D FwdD. (188 aa)
fwdBTungsten formylmethanofuran dehydrogenase subunit B FwdB. (458 aa)
fwdATungsten formylmethanofuran dehydrogenase subunit A FwdA. (574 aa)
fwdCTungsten formylmethanofuran dehydrogenase subunit C FwdC. (288 aa)
fwdETungsten formylmethanofuran dehydrogenase subunit E FwdE. (190 aa)
Abm4_01503-hexulose-6-phosphate isomerase Phi1. (196 aa)
aksDHomoaconitase large subunit AksD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa)
aksAHomocitrate synthase AksA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa)
serBPhosphoserine phosphatase SerB. (499 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa)
fbpFructose 1,6-bisphosphatase Fbp; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa)
serAPhosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa)
Abm4_0441Demethylmenaquinone methyltransferase. (256 aa)
Abm4_0504Hypothetical protein. (385 aa)
Abm4_0505H4MPT-linked C1 transfer pathway protein. (347 aa)
aksEHomoaconitase small subunit AksE; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD [...] (161 aa)
aroA-2Phospho-2-dehydro-3-deoxyheptonate aldolase/fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa)
comAPhosphosulfolactate synthase ComA. (257 aa)
hdrC1CoB--CoM heterodisulfide reductase subunit C HdrC1. (204 aa)
hdrB1CoB--CoM heterodisulfide reductase subunit B HdrB1. (348 aa)
hdrA1CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa)
comESulfopyruvate decarboxylase beta subunit ComE. (178 aa)
comDSulfopyruvate decarboxylase alpha subunit ComD. (168 aa)
mfnBHypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (238 aa)
cofHFO synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (374 aa)
Abm4_0774Methyl-coenzyme M reductase component A2-like protein. (574 aa)
Abm4_0809Homoserine kinase. (410 aa)
frhB2Coenzyme F420 hydrogenase beta subunit FrhB2. (360 aa)
mvhD2Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa)
fdhB2Formate dehydrogenase beta subunit FdhB2. (385 aa)
fdhA2Formate dehydrogenase alpha subunit FdhA2. (343 aa)
ftr1Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr1. (297 aa)
acsAacetyl-CoA synthetase AcsA. (564 aa)
gltAGlutamate synthase alpha subunit GltA; Belongs to the glutamate synthase family. (497 aa)
gltBGlutamate synthase beta subunit GltB. (225 aa)
Abm4_0996Glutamine amidotransferase. (307 aa)
aksFIsohomocitrate dehydrogenase AksF. (337 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (322 aa)
cofC2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (226 aa)
enoPhosphopyruvate hydratase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa)
Abm4_12914Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (328 aa)
hdrB2CoB--CoM heterodisulfide reductase subunit B HdrB2. (294 aa)
hdrC2CoB--CoM heterodisulfide reductase subunit C HdrC2. (347 aa)
Abm4_13903-hexulose-6-phosphate isomerase Phi1. (200 aa)
mer5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa)
porCPyruvate ferredoxin oxidoreductase gamma subunit PorC. (173 aa)
porDPyruvate ferredoxin oxidoreductase delta subunit PorD. (82 aa)
porAPyruvate ferredoxin oxidoreductase alpha subunit PorA. (384 aa)
porBPyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa)
porEPyruvate ferredoxin oxidoreductase-associated PorE. (164 aa)
porFPyruvate ferredoxin oxidoreductase-associated PorF. (144 aa)
Abm4_1458Aspartate/glutamate/uridylate kinase. (223 aa)
atwAMethyl-coenzyme M reductase component A2 AtwA. (536 aa)
cofDLPPG:FO 2-phospho-L-lactate transferase CofD; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (303 aa)
cofE2F420-0:gamma-glutamyl ligase CofE2; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (254 aa)
mfnAL-tyrosine decarboxylase MfnA; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (387 aa)
ppsAPhosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (760 aa)
mvhAMethyl viologen-reducing hydrogenase alpha subunit MvhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (474 aa)
mvhGMethyl viologen-reducing hydrogenase gamma subunit MvhG. (309 aa)
mvhDMethyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa)
mtrHTetrahydromethanopterin S-methyltransferase subunit H MtrH. (313 aa)
mtrGTetrahydromethanopterin S-methyltransferase subunit G MtrG; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (83 aa)
mtrFTetrahydromethanopterin S-methyltransferase subunit F MtrF. (68 aa)
mtrATetrahydromethanopterin S-methyltransferase subunit A MtrA; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa)
mtrBTetrahydromethanopterin S-methyltransferase subunit B MtrB; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (108 aa)
mtrCTetrahydromethanopterin S-methyltransferase subunit C MtrC; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (263 aa)
mtrDTetrahydromethanopterin S-methyltransferase subunit D MtrD; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (233 aa)
mtrETetrahydromethanopterin S-methyltransferase subunit E MtrE; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (293 aa)
mcrAMethyl-coenzyme M reductase alpha subunit McrA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (551 aa)
mcrGMethyl-coenzyme M reductase gamma subunit McrG. (249 aa)
mcrCMethyl-coenzyme M reductase C subunit McrC. (198 aa)
mcrDMethyl-coenzyme M reductase D subunit McrD. (151 aa)
mcrBMethyl-coenzyme M reductase beta subunit McrB. (443 aa)
comB2-phosphosulfolactate phosphatase ComB. (232 aa)
cofGFO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (379 aa)
comCL-sulfolactate dehydrogenase ComC. (342 aa)
ftr2Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr2; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (293 aa)
frhB1Coenzyme F420 hydrogenase beta subunit FrhB1. (292 aa)
frhGCoenzyme F420 hydrogenase gamma subunit FrhG. (271 aa)
frhDCoenzyme F420 hydrogenase delta subunit FrhD. (159 aa)
frhACoenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa)
glyASerine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa)
hdrA2CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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