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| | hmd | Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase Hmd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (339 aa) |
| | sdhA | Succinate dehydrogenase/fumarate reductase flavoprotein subunit SdhA. (558 aa) |
| | mtd | F420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa) |
| | fae-hps | Bifunctional formaldehyde-activating enzyme/3- hexulose-6-phosphate synthase Fae/Hps; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (407 aa) |
| | Abm4_0121 | Methanogenesis marker protein 13. (362 aa) |
| | fdhA | Formate dehydrogenase alpha subunit FdhA. (688 aa) |
| | fdhB | Formate dehydrogenase beta subunit FdhB. (411 aa) |
| | fwdH | Tungsten formylmethanofuran dehydrogenase subunit H FwdH. (155 aa) |
| | fwdF | Tungsten formylmethanofuran dehydrogenase subunit F FwdF. (367 aa) |
| | fwdG | Tungsten formylmethanofuran dehydrogenase subunit G FwdG. (76 aa) |
| | fwdD | Tungsten formylmethanofuran dehydrogenase subunit D FwdD. (188 aa) |
| | fwdB | Tungsten formylmethanofuran dehydrogenase subunit B FwdB. (458 aa) |
| | fwdA | Tungsten formylmethanofuran dehydrogenase subunit A FwdA. (574 aa) |
| | fwdC | Tungsten formylmethanofuran dehydrogenase subunit C FwdC. (288 aa) |
| | fwdE | Tungsten formylmethanofuran dehydrogenase subunit E FwdE. (190 aa) |
| | Abm4_0150 | 3-hexulose-6-phosphate isomerase Phi1. (196 aa) |
| | glnA | Glutamine synthetase GlnA. (446 aa) |
| | aksD | Homoaconitase large subunit AksD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa) |
| | aksA | Homocitrate synthase AksA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa) |
| | serB | Phosphoserine phosphatase SerB. (499 aa) |
| | dmpI | 4-oxalocrotonate tautomerase family enzyme DmpI. (63 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa) |
| | glmM2 | Phosphoglucosamine mutase GlmM2; Belongs to the phosphohexose mutase family. (454 aa) |
| | Abm4_0243 | Dihydrolipoamide dehydrogenase-related protein. (427 aa) |
| | fbp | Fructose 1,6-bisphosphatase Fbp; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | pycB | Pyruvate carboxylase subunit B PycB. (569 aa) |
| | fumA1 | Fumarate hydratase FumA1. (165 aa) |
| | korD | 2-oxoglutarate ferredoxin oxidoreductase subunit delta KorD. (88 aa) |
| | korA | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha KorA. (377 aa) |
| | korB | 2-oxoglutarate ferredoxin oxidoreductase subunit beta KorB. (310 aa) |
| | korC | 2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC. (183 aa) |
| | sucC | succinyl-CoA synthetase beta subunit SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (369 aa) |
| | tpiA | Triosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa) |
| | pgk | Phosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (410 aa) |
| | cofA | Lactaldehyde dehydrogenase CofA; Belongs to the aldehyde dehydrogenase family. (470 aa) |
| | serA | Phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | fumA2 | Fumarate hydratase FumA2. (293 aa) |
| | Abm4_0441 | Demethylmenaquinone methyltransferase. (256 aa) |
| | hemC | Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (291 aa) |
| | Abm4_0460 | Cell wall biosynthesis protein Mur ligase family. (480 aa) |
| | aksE | Homoaconitase small subunit AksE; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD [...] (161 aa) |
| | ask | Aspartate kinase Ask; Belongs to the aspartokinase family. (408 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | Abm4_0564 | acetyl-CoA acetyltransferase. (386 aa) |
| | prs | Ribose-phosphate diphosphokinase Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (296 aa) |
| | cbiX1 | Cobalamin biosynthesis protein CbiX1; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (152 aa) |
| | aroA-2 | Phospho-2-dehydro-3-deoxyheptonate aldolase/fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase HemL. (428 aa) |
| | comA | Phosphosulfolactate synthase ComA. (257 aa) |
| | hdrC1 | CoB--CoM heterodisulfide reductase subunit C HdrC1. (204 aa) |
| | hdrB1 | CoB--CoM heterodisulfide reductase subunit B HdrB1. (348 aa) |
| | hdrA1 | CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa) |
| | comE | Sulfopyruvate decarboxylase beta subunit ComE. (178 aa) |
| | comD | Sulfopyruvate decarboxylase alpha subunit ComD. (168 aa) |
| | thrC | Threonine synthase ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (401 aa) |
| | Abm4_0733 | 4Fe-4S iron sulfur cluster binding protein NifH/frxC family; Belongs to the NifH/BchL/ChlL family. (267 aa) |
| | ubiX | 3-polyprenyl-4-hydroxybenzoate decarboxylase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (183 aa) |
| | cofH | FO synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (374 aa) |
| | Abm4_0774 | Methyl-coenzyme M reductase component A2-like protein. (574 aa) |
| | ftsA1 | Coenzyme F390 synthetase FtsA1. (433 aa) |
| | hom | Homoserine dehydrogenase Hom. (340 aa) |
| | Abm4_0809 | Homoserine kinase. (410 aa) |
| | frhB2 | Coenzyme F420 hydrogenase beta subunit FrhB2. (360 aa) |
| | gdhA | Glutamate dehydrogenase GdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | mvhD2 | Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa) |
| | fdhB2 | Formate dehydrogenase beta subunit FdhB2. (385 aa) |
| | fdhA2 | Formate dehydrogenase alpha subunit FdhA2. (343 aa) |
| | sucD | succinate-CoA ligase alpha subunit SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa) |
| | ftr1 | Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr1. (297 aa) |
| | acsA | acetyl-CoA synthetase AcsA. (564 aa) |
| | gltA | Glutamate synthase alpha subunit GltA; Belongs to the glutamate synthase family. (497 aa) |
| | gltB | Glutamate synthase beta subunit GltB. (225 aa) |
| | Abm4_0996 | Glutamine amidotransferase. (307 aa) |
| | aksF | Isohomocitrate dehydrogenase AksF. (337 aa) |
| | cobA | uroporphyrin-III C-methyltransferase CobA; Belongs to the precorrin methyltransferase family. (248 aa) |
| | hemD | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (261 aa) |
| | hbd | 3-hydroxybutyryl-CoA dehydrogenase Hbd. (311 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. (337 aa) |
| | acs | ADP-dependent acetyl-CoA synthetase Acs. (698 aa) |
| | cysE | Serine O-acetyltransferase CysE. (227 aa) |
| | cysKM | Cysteine synthase CysKM. (329 aa) |
| | mch | Methenyltetrahydromethanopterin cyclohydrolase Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (322 aa) |
| | rpiA | Ribose 5-phosphate isomerase A RpiA; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (226 aa) |
| | gltX | glutamyl-tRNA synthetase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (557 aa) |
| | eno | Phosphopyruvate hydratase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa) |
| | pycA | Pyruvate carboxylase subunit A PycA. (495 aa) |
| | fumA3 | Fumarate hydratase FumA3. (173 aa) |
| | Abm4_1291 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (328 aa) |
| | hdrB2 | CoB--CoM heterodisulfide reductase subunit B HdrB2. (294 aa) |
| | hdrC2 | CoB--CoM heterodisulfide reductase subunit C HdrC2. (347 aa) |
| | ftsA2 | Coenzyme F390 synthetase FtsA2. (432 aa) |
| | sdhB | Succinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (497 aa) |
| | Abm4_1390 | 3-hexulose-6-phosphate isomerase Phi1. (200 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa) |
| | porC | Pyruvate ferredoxin oxidoreductase gamma subunit PorC. (173 aa) |
| | porD | Pyruvate ferredoxin oxidoreductase delta subunit PorD. (82 aa) |
| | porA | Pyruvate ferredoxin oxidoreductase alpha subunit PorA. (384 aa) |
| | porB | Pyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa) |
| | porE | Pyruvate ferredoxin oxidoreductase-associated PorE. (164 aa) |
| | porF | Pyruvate ferredoxin oxidoreductase-associated PorF. (144 aa) |
| | fumA4 | Fumarate hydratase FumA4. (280 aa) |
| | Abm4_1462 | Carboxymuconolactone decarboxylase family protein. (251 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase Gap. (337 aa) |
| | hemA | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (412 aa) |
| | cysG | Siroheme synthase CysG. (223 aa) |
| | atwA | Methyl-coenzyme M reductase component A2 AtwA. (536 aa) |
| | cofD | LPPG:FO 2-phospho-L-lactate transferase CofD; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (303 aa) |
| | cofE2 | F420-0:gamma-glutamyl ligase CofE2; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (254 aa) |
| | ppsA | Phosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (760 aa) |
| | mvhA | Methyl viologen-reducing hydrogenase alpha subunit MvhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (474 aa) |
| | mvhG | Methyl viologen-reducing hydrogenase gamma subunit MvhG. (309 aa) |
| | mvhD | Methyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase subunit H MtrH. (313 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase subunit G MtrG; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (83 aa) |
| | mtrF | Tetrahydromethanopterin S-methyltransferase subunit F MtrF. (68 aa) |
| | mtrA | Tetrahydromethanopterin S-methyltransferase subunit A MtrA; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase subunit B MtrB; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (108 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase subunit C MtrC; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (263 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase subunit D MtrD; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (233 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase subunit E MtrE; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (293 aa) |
| | mcrA | Methyl-coenzyme M reductase alpha subunit McrA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (551 aa) |
| | mcrG | Methyl-coenzyme M reductase gamma subunit McrG. (249 aa) |
| | mcrC | Methyl-coenzyme M reductase C subunit McrC. (198 aa) |
| | mcrD | Methyl-coenzyme M reductase D subunit McrD. (151 aa) |
| | mcrB | Methyl-coenzyme M reductase beta subunit McrB. (443 aa) |
| | comB | 2-phosphosulfolactate phosphatase ComB. (232 aa) |
| | cofG | FO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (379 aa) |
| | ftr2 | Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr2; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (293 aa) |
| | Abm4_1628 | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (498 aa) |
| | frhB1 | Coenzyme F420 hydrogenase beta subunit FrhB1. (292 aa) |
| | frhG | Coenzyme F420 hydrogenase gamma subunit FrhG. (271 aa) |
| | frhD | Coenzyme F420 hydrogenase delta subunit FrhD. (159 aa) |
| | frhA | Coenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (286 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa) |
| | hdrA2 | CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa) |
| | Abm4_1723 | UbiD family decarboxylase. (428 aa) |
| | Abm4_1735 | Class II aldolase/adducin family protein. (197 aa) |
