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hmd hmd sdhA sdhA mtd mtd fae-hps fae-hps fdhA fdhA fdhB fdhB fwdH fwdH fwdF fwdF fwdG fwdG fwdD fwdD fwdB fwdB fwdA fwdA fwdC fwdC fwdE fwdE Abm4_0150 Abm4_0150 serB serB apgM apgM Abm4_0243 Abm4_0243 fbp fbp pycB pycB fumA1 fumA1 korD korD korA korA korB korB korC korC sucC sucC tpiA tpiA pgk pgk serA serA fumA2 fumA2 Abm4_0441 Abm4_0441 Abm4_0564 Abm4_0564 prs prs aroA-2 aroA-2 hdrC1 hdrC1 hdrB1 hdrB1 hdrA1 hdrA1 Abm4_0809 Abm4_0809 mvhD2 mvhD2 fdhB2 fdhB2 fdhA2 fdhA2 sucD sucD ftr1 ftr1 acsA acsA cysE cysE cysKM cysKM mch mch rpiA rpiA eno eno pycA pycA fumA3 fumA3 Abm4_1291 Abm4_1291 hdrB2 hdrB2 hdrC2 hdrC2 sdhB sdhB Abm4_1390 Abm4_1390 mer mer porC porC porD porD porA porA porB porB porE porE porF porF fumA4 fumA4 gap gap ppsA ppsA mvhA mvhA mvhG mvhG mvhD mvhD mtrH mtrH mtrG mtrG mtrF mtrF mtrA mtrA mtrB mtrB mtrC mtrC mtrD mtrD mtrE mtrE mcrA mcrA mcrG mcrG mcrB mcrB ftr2 ftr2 glyA glyA hdrA2 hdrA2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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hmdCoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase Hmd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (339 aa)
sdhASuccinate dehydrogenase/fumarate reductase flavoprotein subunit SdhA. (558 aa)
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
fae-hpsBifunctional formaldehyde-activating enzyme/3- hexulose-6-phosphate synthase Fae/Hps; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (407 aa)
fdhAFormate dehydrogenase alpha subunit FdhA. (688 aa)
fdhBFormate dehydrogenase beta subunit FdhB. (411 aa)
fwdHTungsten formylmethanofuran dehydrogenase subunit H FwdH. (155 aa)
fwdFTungsten formylmethanofuran dehydrogenase subunit F FwdF. (367 aa)
fwdGTungsten formylmethanofuran dehydrogenase subunit G FwdG. (76 aa)
fwdDTungsten formylmethanofuran dehydrogenase subunit D FwdD. (188 aa)
fwdBTungsten formylmethanofuran dehydrogenase subunit B FwdB. (458 aa)
fwdATungsten formylmethanofuran dehydrogenase subunit A FwdA. (574 aa)
fwdCTungsten formylmethanofuran dehydrogenase subunit C FwdC. (288 aa)
fwdETungsten formylmethanofuran dehydrogenase subunit E FwdE. (190 aa)
Abm4_01503-hexulose-6-phosphate isomerase Phi1. (196 aa)
serBPhosphoserine phosphatase SerB. (499 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa)
Abm4_0243Dihydrolipoamide dehydrogenase-related protein. (427 aa)
fbpFructose 1,6-bisphosphatase Fbp; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa)
pycBPyruvate carboxylase subunit B PycB. (569 aa)
fumA1Fumarate hydratase FumA1. (165 aa)
korD2-oxoglutarate ferredoxin oxidoreductase subunit delta KorD. (88 aa)
korA2-oxoglutarate ferredoxin oxidoreductase subunit alpha KorA. (377 aa)
korB2-oxoglutarate ferredoxin oxidoreductase subunit beta KorB. (310 aa)
korC2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC. (183 aa)
sucCsuccinyl-CoA synthetase beta subunit SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (369 aa)
tpiATriosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa)
pgkPhosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (410 aa)
serAPhosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa)
fumA2Fumarate hydratase FumA2. (293 aa)
Abm4_0441Demethylmenaquinone methyltransferase. (256 aa)
Abm4_0564acetyl-CoA acetyltransferase. (386 aa)
prsRibose-phosphate diphosphokinase Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (296 aa)
aroA-2Phospho-2-dehydro-3-deoxyheptonate aldolase/fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa)
hdrC1CoB--CoM heterodisulfide reductase subunit C HdrC1. (204 aa)
hdrB1CoB--CoM heterodisulfide reductase subunit B HdrB1. (348 aa)
hdrA1CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (776 aa)
Abm4_0809Homoserine kinase. (410 aa)
mvhD2Methyl viologen-reducing hydrogenase delta subunit MvhD2. (129 aa)
fdhB2Formate dehydrogenase beta subunit FdhB2. (385 aa)
fdhA2Formate dehydrogenase alpha subunit FdhA2. (343 aa)
sucDsuccinate-CoA ligase alpha subunit SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa)
ftr1Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr1. (297 aa)
acsAacetyl-CoA synthetase AcsA. (564 aa)
cysESerine O-acetyltransferase CysE. (227 aa)
cysKMCysteine synthase CysKM. (329 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (322 aa)
rpiARibose 5-phosphate isomerase A RpiA; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
enoPhosphopyruvate hydratase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa)
pycAPyruvate carboxylase subunit A PycA. (495 aa)
fumA3Fumarate hydratase FumA3. (173 aa)
Abm4_12914Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (328 aa)
hdrB2CoB--CoM heterodisulfide reductase subunit B HdrB2. (294 aa)
hdrC2CoB--CoM heterodisulfide reductase subunit C HdrC2. (347 aa)
sdhBSuccinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (497 aa)
Abm4_13903-hexulose-6-phosphate isomerase Phi1. (200 aa)
mer5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa)
porCPyruvate ferredoxin oxidoreductase gamma subunit PorC. (173 aa)
porDPyruvate ferredoxin oxidoreductase delta subunit PorD. (82 aa)
porAPyruvate ferredoxin oxidoreductase alpha subunit PorA. (384 aa)
porBPyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa)
porEPyruvate ferredoxin oxidoreductase-associated PorE. (164 aa)
porFPyruvate ferredoxin oxidoreductase-associated PorF. (144 aa)
fumA4Fumarate hydratase FumA4. (280 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase Gap. (337 aa)
ppsAPhosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (760 aa)
mvhAMethyl viologen-reducing hydrogenase alpha subunit MvhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (474 aa)
mvhGMethyl viologen-reducing hydrogenase gamma subunit MvhG. (309 aa)
mvhDMethyl viologen-reducing hydrogenase delta subunit MvhD. (139 aa)
mtrHTetrahydromethanopterin S-methyltransferase subunit H MtrH. (313 aa)
mtrGTetrahydromethanopterin S-methyltransferase subunit G MtrG; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (83 aa)
mtrFTetrahydromethanopterin S-methyltransferase subunit F MtrF. (68 aa)
mtrATetrahydromethanopterin S-methyltransferase subunit A MtrA; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa)
mtrBTetrahydromethanopterin S-methyltransferase subunit B MtrB; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (108 aa)
mtrCTetrahydromethanopterin S-methyltransferase subunit C MtrC; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (263 aa)
mtrDTetrahydromethanopterin S-methyltransferase subunit D MtrD; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (233 aa)
mtrETetrahydromethanopterin S-methyltransferase subunit E MtrE; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (293 aa)
mcrAMethyl-coenzyme M reductase alpha subunit McrA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (551 aa)
mcrGMethyl-coenzyme M reductase gamma subunit McrG. (249 aa)
mcrBMethyl-coenzyme M reductase beta subunit McrB. (443 aa)
ftr2Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr2; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (293 aa)
glyASerine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa)
hdrA2CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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