STRINGSTRING
Nit Nit gshB gshB hrcA hrcA grpE grpE dnaK dnaK dnaJ dnaJ irr irr katG katG msrA msrA ndvA ndvA cspA cspA nodQ nodQ cysD-2 cysD-2 nolK nolK noeL noeL nodM nodM hupH hupH nifX nifX nifB nifB nifZ nifZ nifH nifH nifQ nifQ nifW nifW nodD2 nodD2 nodD1 nodD1 nodA nodA nodB nodB nodC nodC nodS nodS nodU nodU nolO nolO nodZ nodZ nifA nifA noeI noeI FixK FixK cspA-2 cspA-2 copA copA AND87903.1 AND87903.1 dnaJ-2 dnaJ-2 AND88201.1 AND88201.1 htrA htrA fixK fixK fixJ fixJ fixN fixN AND88263.1 AND88263.1 AND88470.1 AND88470.1 tolC tolC arsC arsC cspA-3 cspA-3 AND88615.1 AND88615.1 AND88774.1 AND88774.1 FixK-2 FixK-2 betB betB AND89115.1 AND89115.1 cspA-4 cspA-4 dnaJ-3 dnaJ-3 gltA gltA hup hup lon lon AND90176.1 AND90176.1 AND90271.1 AND90271.1 mscL mscL rpoH1 rpoH1 arsB arsB tuf tuf fusA fusA lpcC lpcC fixK-2 fixK-2 clc clc lon-2 lon-2 msrA-2 msrA-2 AND94308.1 AND94308.1 AND91473.1 AND91473.1 tms2 tms2 AND91721.1 AND91721.1 hupJ hupJ hupI hupI hupH-2 hupH-2 hupG hupG hupA-2 hupA-2 msrA-3 msrA-3 cspA-5 cspA-5 cspA-6 cspA-6 exoT exoT FixK-3 FixK-3 lepA lepA cspA-7 cspA-7 traG traG cspA-8 cspA-8 cisZ cisZ cis cis dnaJ-4 dnaJ-4 acdS acdS bam bam otsA otsA otsB otsB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NitNitrilase; Nitrilase that acts on various kinds of nitrile compounds such as aliphatic and aromatic nitriles. Has higher activity toward aliphatic nitriles compared to aromatic nitriles. Among the different substrates tested, has the highest activity toward hydrocinnamonitrile. Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. (321 aa)
gshBGlutathione synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
hrcAHeat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (362 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (201 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (377 aa)
irrFur family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (163 aa)
katGHydroperoxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (721 aa)
msrAMethionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (218 aa)
ndvACyclic beta-1,2-glucan ABC transporter; Involved in beta-(1-->2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). (602 aa)
cspACold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
nodQNodQ bifunctional enzyme; Catalyzes the synthesis of activated sulfate. (638 aa)
cysD-2Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
nolKGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (335 aa)
noeLGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (361 aa)
nodMGlucosamine--fructose-6-phosphate aminotransferase; Involved in the production of the root hair deformation (HAD) factor specifically on soybean. (608 aa)
hupHHydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
nifXNitrogen fixation protein NifX; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
nifBNitrogen fixation protein NifB; Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster. (519 aa)
nifZNitrogen fixation protein NifZ; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
nifHNitrogenase reductase; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (294 aa)
nifQMolybdenum processing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
nifWNitrogenase stabilizing/protective protein; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family. (113 aa)
nodD2LysR family transcriptional regulator; NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers (By similarity). (330 aa)
nodD1LysR family transcriptional regulator; NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers (By similarity). (314 aa)
nodAAcyltransferase; N-acyltransferase required for nodulation. Acts in the production of a small, heat-stable compound (Nod) that stimulates mitosis in various plant protoplasts; Belongs to the NodA family. (210 aa)
nodBChitooligosaccharide deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
nodCN-acetylglucosaminyltransferase; May be involved in the synthesis of NodRm-1, a sulfated N- acyl-beta-1,4-tetrasaccharide of N-acetylglucosamine which initiates a series of events in the host plant species leading eventually to nodulation; Belongs to the NodC/HAS family. (485 aa)
nodSSAM-dependent methlyltransferase; SAM-utilizing methyltransferase involved in nod factor synthesis. (209 aa)
nodUNodulation protein NodU; Involved in 6-O-carbamoylation of Nod-factors. (569 aa)
nolONodulation protein; Involved in 6-O-carbamoylation of Nod-factors. (548 aa)
nodZNodulation protein NodZ; Fucosyltransferase which adds the fucose moiety of the nod factor on its terminal reducing N-acetylglucosamine end. Uses GDP- fucose as the donor group. (328 aa)
nifAATPase AAA; Required for activation of most nif operons, which are directly involved in nitrogen fixation. (605 aa)
noeIMethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
FixKTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
cspA-2Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
copACopper oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
AND87903.1Choline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
dnaJ-2Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
AND88201.1Choline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
htrASerine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
fixKTranscriptional regulator that positively regulated fixLJ operon; upregulated transcription by FixJ; part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
fixJResponse regulator FixJ; FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for FixN activation. (205 aa)
fixNCytochrome C oxidase; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B. (549 aa)
AND88263.1Sugar transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AND88470.1Choline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
tolCTransporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
arsCArsenate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
cspA-3Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (69 aa)
AND88615.1Amino acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (785 aa)
AND88774.1Cellulase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (341 aa)
FixK-2Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
betBBetaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (494 aa)
AND89115.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (537 aa)
cspA-4Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (69 aa)
dnaJ-3Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
hupDNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (99 aa)
lonDNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (807 aa)
AND90176.1Multicopper oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
AND90271.1GMC family oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (138 aa)
rpoH1RNA polymerase sigma 70; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (308 aa)
arsBArsenic transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (690 aa)
lpcCLipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
fixK-2Nitrogen fixation protein FixK; B.japonicum has two FixLJ-dependent FixK homologs that are activators of the transcription of a group of genes involved in anaerobic processes such as denitrification and possibly nitrogen fixation. FixK may bind DNA at the FNR consensus binding site. (237 aa)
clcChloride channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
lon-2DNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (796 aa)
msrA-2Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (171 aa)
AND94308.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AND91473.1Amidohydrolase; Nitrilase that mediates the hydrolysis of aromatic alpha- hydroxy nitriles to carboxylic acids. Has high activity toward mandelonitrile and mediates its hydrolysis to mandelic acid. Also mediates hydrolysis of mandelonitrile derivatives. Has weak activity toward aliphatic nitriles; Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. (334 aa)
tms2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family. (469 aa)
AND91721.1Choline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
hupJHydrogenase formation protein HupJ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupJ family. (169 aa)
hupIRubredoxin; Could be an electron transport intermediate in hydrogen oxidation; Belongs to the rubredoxin family. (69 aa)
hupH-2Hydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupH/HyaF family. (287 aa)
hupGHydrogenase accessory protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HupG/HyaE family. (148 aa)
hupA-2Uptake hydrogenase small subunit; This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. (363 aa)
msrA-3Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (234 aa)
cspA-5Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
cspA-6Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
exoTUDP-hexose transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyltransferase 26 family. (268 aa)
FixK-3Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (603 aa)
cspA-7Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
traGConjugal transfer protein TraG; Type IV secretion VirD4 coupling protein family; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
cspA-8Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
cisZCitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (405 aa)
cisCitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (364 aa)
dnaJ-4Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
acdS1-aminocyclopropane-1-carboxylate deaminase; Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (337 aa)
bamAmidase; Hydrolyzes indole-3-acetamide (IAM) into indole-3-acetic acid (IAA); Belongs to the amidase family. (524 aa)
otsAAlpha,alpha-trehalose-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
otsBTrehalose phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (273 aa)
Your Current Organism:
Bradyrhizobium diazoefficiens
NCBI taxonomy Id: 224911
Other names: B. diazoefficiens USDA 110, Bradyrhizobium diazoefficiens USDA 110, Bradyrhizobium japonicum USDA 110
Server load: low (40%) [HD]