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Sps_00181 Sps_00181 Sps_00324 Sps_00324 Sps_00330 Sps_00330 acsA acsA Sps_00533 Sps_00533 Sps_00534 Sps_00534 Sps_00563 Sps_00563 purU purU Sps_00759 Sps_00759 Sps_00765 Sps_00765 glcB glcB Sps_00769 Sps_00769 Sps_00789 Sps_00789 Sps_00790 Sps_00790 Sps_00791 Sps_00791 Sps_01091 Sps_01091 Sps_01124 Sps_01124 Sps_01597 Sps_01597 sucD sucD sucC sucC Sps_01627 Sps_01627 Sps_01628 Sps_01628 Sps_01629 Sps_01629 Sps_01630 Sps_01630 Sps_01631 Sps_01631 Sps_01632 Sps_01632 Sps_01633 Sps_01633 Sps_01654 Sps_01654 Sps_01667 Sps_01667 Sps_01808 Sps_01808 Sps_02026 Sps_02026 Sps_02027 Sps_02027 Sps_02028 Sps_02028 prpB prpB Sps_02030 Sps_02030 Sps_02045 Sps_02045 Sps_02077 Sps_02077 purU-2 purU-2 Sps_02235 Sps_02235 Sps_02443 Sps_02443 Sps_02565 Sps_02565 Sps_02566 Sps_02566 Sps_02664 Sps_02664 mdh mdh Sps_02823 Sps_02823 Sps_02824 Sps_02824 Sps_03073 Sps_03073 Sps_03074 Sps_03074 Sps_03075 Sps_03075 Sps_03076 Sps_03076 ackA ackA Sps_03568 Sps_03568 Sps_03850 Sps_03850 Sps_03945 Sps_03945 Sps_04082 Sps_04082 Sps_04083 Sps_04083 oadG oadG eno eno maeA maeA Sps_04622 Sps_04622 Sps_04933 Sps_04933 Sps_04949 Sps_04949 fumC fumC Sps_05247 Sps_05247 Sps_05361 Sps_05361 Sps_05371 Sps_05371 Sps_05377 Sps_05377 Sps_05378 Sps_05378 Sps_05379 Sps_05379 ppc ppc pckA pckA Sps_05513 Sps_05513 Sps_05514 Sps_05514 Sps_05515 Sps_05515 Sps_05519 Sps_05519 Sps_05520 Sps_05520 Sps_05521 Sps_05521
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Sps_00181'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain'; 'TIGRFAM: glutathione-disulfide reductase, animal/bacterial'. (451 aa)
Sps_00324PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (506 aa)
Sps_00330Putative quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; 'TIGRFAM: putative quinone oxidoreductase, YhdH/YhfP family'. (326 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
Sps_00533Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
Sps_00534Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
Sps_00563PFAM: Monomeric isocitrate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type'; Belongs to the monomeric-type IDH family. (741 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
Sps_00759Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
Sps_00765PFAM: Isocitrate lyase family. (527 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa)
Sps_00769Alcohol dehydrogenase AdhE; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa)
Sps_00789Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit; PFAM: Dehydrogenase E1 component. (392 aa)
Sps_00790Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; 'PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (320 aa)
Sps_00791Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme. (536 aa)
Sps_01091'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (413 aa)
Sps_01124'PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain'; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
Sps_01597PFAM: Cytochrome c3. (114 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
Sps_016272-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa)
Sps_01628'PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain'; 'TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component'. (940 aa)
Sps_01629Succinate dehydrogenase subunit B; PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (235 aa)
Sps_01630Succinate dehydrogenase subunit A; PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; 'TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup'; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
Sps_01631Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
Sps_01632PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; 'TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit'. (124 aa)
Sps_01633PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (430 aa)
Sps_01654PFAM: Acylphosphatase. (91 aa)
Sps_01667Thioredoxin domain-containing protein; PFAM: Thioredoxin; Tetratricopeptide repeat. (281 aa)
Sps_01808Hypothetical protein. (171 aa)
Sps_020262-methylaconitate cis-trans isomerase; PFAM: PrpF protein; TIGRFAM: probable AcnD-accessory protein PrpF. (426 aa)
Sps_02027PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); 'TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; aconitate hydratase 1'. (868 aa)
Sps_02028PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (374 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (292 aa)
Sps_02030'PFAM: Bacterial regulatory proteins, gntR family; FCD domain'. (221 aa)
Sps_02045Methylmalonate-semialdehyde dehydrogenase (acylating); PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. (501 aa)
Sps_02077propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa)
Sps_02235PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. (335 aa)
Sps_02443Hypothetical protein; PFAM: Flavinator of succinate dehydrogenase. (83 aa)
Sps_02565PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
Sps_02566Methylmalonate-semialdehyde dehydrogenase (acylating); PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. (501 aa)
Sps_02664PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (456 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
Sps_02823PFAM: Aminotransferase class-III; 'TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
Sps_02824PFAM: Aldehyde dehydrogenase family; TIGRFAM: succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
Sps_03073Succinate dehydrogenase subunit B; PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa)
Sps_03074Succinate dehydrogenase subunit A; PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; 'TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup'. (670 aa)
Sps_03075PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (242 aa)
Sps_03076PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (243 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
Sps_03568Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa)
Sps_03850PFAM: Malate synthase; TIGRFAM: malate synthase A. (483 aa)
Sps_03945PFAM: Malate synthase; TIGRFAM: malate synthase A. (547 aa)
Sps_04082Sodium ion-translocating decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa)
Sps_04083Oxaloacetate decarboxylase alpha subunit; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit. (600 aa)
oadGSodium pump decarboxylase gamma subunit family protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (81 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (430 aa)
maeA'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (562 aa)
Sps_04622'PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (747 aa)
Sps_04933Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (329 aa)
Sps_04949PFAM: FAD binding domain; Cytochrome c3; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (595 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
Sps_05247PEP phosphonomutase-like enzyme; PFAM: Phosphoenolpyruvate phosphomutase. (276 aa)
Sps_05361'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (415 aa)
Sps_05371Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa)
Sps_05377Dihydrolipoamide dehydrogenase; 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain'; TIGRFAM: dihydrolipoamide dehydrogenase. (476 aa)
Sps_05378Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa)
Sps_05379Pyruvate dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
ppcPhosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
pckAATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa)
Sps_05513Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (328 aa)
Sps_05514Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (189 aa)
Sps_05515Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (951 aa)
Sps_05519Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (341 aa)
Sps_05520Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (196 aa)
Sps_05521Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (949 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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