STRINGSTRING
Sps_00324 Sps_00324 Sps_00330 Sps_00330 acsA acsA Sps_00533 Sps_00533 Sps_00534 Sps_00534 purU purU Sps_00759 Sps_00759 Sps_00765 Sps_00765 glcB glcB Sps_00769 Sps_00769 Sps_01091 Sps_01091 Sps_01124 Sps_01124 Sps_01654 Sps_01654 Sps_02045 Sps_02045 Sps_02077 Sps_02077 purU-2 purU-2 Sps_02565 Sps_02565 Sps_02566 Sps_02566 mdh mdh ackA ackA Sps_03568 Sps_03568 Sps_03850 Sps_03850 Sps_03945 Sps_03945 Sps_04082 Sps_04082 Sps_04083 Sps_04083 oadG oadG eno eno maeA maeA Sps_04933 Sps_04933 fumC fumC Sps_05361 Sps_05361 Sps_05379 Sps_05379 ppc ppc pckA pckA Sps_05513 Sps_05513 Sps_05514 Sps_05514 Sps_05515 Sps_05515 Sps_05519 Sps_05519 Sps_05520 Sps_05520 Sps_05521 Sps_05521
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sps_00324PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (506 aa)
Sps_00330Putative quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; 'TIGRFAM: putative quinone oxidoreductase, YhdH/YhfP family'. (326 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
Sps_00533Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
Sps_00534Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
Sps_00759Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
Sps_00765PFAM: Isocitrate lyase family. (527 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa)
Sps_00769Alcohol dehydrogenase AdhE; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa)
Sps_01091'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (413 aa)
Sps_01124'PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain'; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
Sps_01654PFAM: Acylphosphatase. (91 aa)
Sps_02045Methylmalonate-semialdehyde dehydrogenase (acylating); PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. (501 aa)
Sps_02077propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa)
Sps_02565PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
Sps_02566Methylmalonate-semialdehyde dehydrogenase (acylating); PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. (501 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
Sps_03568Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa)
Sps_03850PFAM: Malate synthase; TIGRFAM: malate synthase A. (483 aa)
Sps_03945PFAM: Malate synthase; TIGRFAM: malate synthase A. (547 aa)
Sps_04082Sodium ion-translocating decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa)
Sps_04083Oxaloacetate decarboxylase alpha subunit; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit. (600 aa)
oadGSodium pump decarboxylase gamma subunit family protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (81 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (430 aa)
maeA'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (562 aa)
Sps_04933Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (329 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
Sps_05361'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (415 aa)
Sps_05379Pyruvate dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
ppcPhosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
pckAATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa)
Sps_05513Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (328 aa)
Sps_05514Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (189 aa)
Sps_05515Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (951 aa)
Sps_05519Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (341 aa)
Sps_05520Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (196 aa)
Sps_05521Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (949 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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