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tdh tdh kbl kbl Sps_00473 Sps_00473 Sps_00691 Sps_00691 Sps_00694 Sps_00694 glyA glyA gcvH gcvH gcvP gcvP glyA-2 glyA-2 Sps_00702 Sps_00702 Sps_00703 Sps_00703 Sps_00704 Sps_00704 Sps_00705 Sps_00705 Sps_00778 Sps_00778 Sps_00806 Sps_00806 Sps_01074 Sps_01074 Sps_01093 Sps_01093 Sps_01099 Sps_01099 Sps_01623 Sps_01623 Sps_01657 Sps_01657 Sps_01705 Sps_01705 folD folD Sps_02326 Sps_02326 Sps_02417 Sps_02417 Sps_02457 Sps_02457 Sps_02458 Sps_02458 Sps_02652 Sps_02652 Sps_02670 Sps_02670 Sps_02671 Sps_02671 Sps_03122 Sps_03122 glyA-3 glyA-3 dsdA dsdA Sps_04230 Sps_04230 Sps_04464 Sps_04464 Sps_04476 Sps_04476 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT gcvT Sps_05173 Sps_05173 fhs fhs
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
Sps_00473Flavodoxin reductase family protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain. (339 aa)
Sps_00691PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein. (375 aa)
Sps_00694PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (455 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
glyA-2Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
Sps_00702PFAM: FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form'. (417 aa)
Sps_00703'PFAM: Sarcosine oxidase, delta subunit family'; 'TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form'. (104 aa)
Sps_00704Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: Pyridine nucleotide-disulphide oxidoreductase; 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. (1007 aa)
Sps_00705'PFAM: Sarcosine oxidase, gamma subunit family'; 'TIGRFAM: sarcosine oxidase, gamma subunit family, heterotetrameric form'. (236 aa)
Sps_00778PFAM: Aminotransferase class I and II. (404 aa)
Sps_008062,4-dienoyl-CoA reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family. (677 aa)
Sps_01074'PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain'; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
Sps_01093Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (360 aa)
Sps_01099PFAM: Ornithine cyclodeaminase/mu-crystallin family. (332 aa)
Sps_01623PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (547 aa)
Sps_01657L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (458 aa)
Sps_017052,4-dienoyl-CoA reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family. (672 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa)
Sps_02326L-threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa)
Sps_02417Flavodoxin reductase family protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain. (367 aa)
Sps_02457Glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1482 aa)
Sps_02458Glutamate synthase (NADPH) small subunit; 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster'; 'TIGRFAM: glutamate synthase small subunit family protein, proteobacterial'. (469 aa)
Sps_02652L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (455 aa)
Sps_02670Aspartate-alanine antiporter; PFAM: Predicted Permease Membrane Region; TrkA-C domain; TIGRFAM: aspartate-alanine antiporter; AspT/YidE/YbjL antiporter duplication domain. (570 aa)
Sps_02671Aspartate 4-decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: aspartate 4-decarboxylase. (529 aa)
Sps_03122Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (380 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
dsdAD-serine ammonia-lyase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (442 aa)
Sps_04230Phosphoserine phosphatase; PFAM: haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. (326 aa)
Sps_04464PFAM: Cytochrome P450. (467 aa)
Sps_04476Glutamate synthase family protein; PFAM: Iron-binding zinc finger CDGSH type; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (523 aa)
gcvP-2Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
Sps_05173Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (358 aa)
fhsPFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (570 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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