STRINGSTRING
tdh tdh kbl kbl Sps_00691 Sps_00691 Sps_00694 Sps_00694 glyA glyA gcvH gcvH gcvP gcvP glyA-2 glyA-2 Sps_00702 Sps_00702 Sps_00703 Sps_00703 Sps_00704 Sps_00704 Sps_00705 Sps_00705 Sps_01093 Sps_01093 Sps_01657 Sps_01657 folD folD Sps_02326 Sps_02326 Sps_02652 Sps_02652 glyA-3 glyA-3 dsdA dsdA Sps_04230 Sps_04230 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT gcvT fhs fhs
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
Sps_00691PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein. (375 aa)
Sps_00694PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (455 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
glyA-2Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
Sps_00702PFAM: FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form'. (417 aa)
Sps_00703'PFAM: Sarcosine oxidase, delta subunit family'; 'TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form'. (104 aa)
Sps_00704Sarcosine oxidase, alpha subunit family, heterotetrameric form; PFAM: Pyridine nucleotide-disulphide oxidoreductase; 2Fe-2S iron-sulfur cluster binding domain; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; 'TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form'; Belongs to the GcvT family. (1007 aa)
Sps_00705'PFAM: Sarcosine oxidase, gamma subunit family'; 'TIGRFAM: sarcosine oxidase, gamma subunit family, heterotetrameric form'. (236 aa)
Sps_01093Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (360 aa)
Sps_01657L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (458 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa)
Sps_02326L-threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa)
Sps_02652L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; 'TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form'. (455 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
dsdAD-serine ammonia-lyase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (442 aa)
Sps_04230Phosphoserine phosphatase; PFAM: haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. (326 aa)
gcvP-2Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
fhsPFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (570 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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