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glpE glpE Sps_00575 Sps_00575 Sps_00587 Sps_00587 Sps_00645 Sps_00645 Sps_00911 Sps_00911 Sps_01137 Sps_01137 Sps_01394 Sps_01394 Sps_01864 Sps_01864 cysS cysS metAS metAS Sps_02143 Sps_02143 mtnN mtnN metK metK cysH cysH cysI cysI Sps_02800 Sps_02800 Sps_02954 Sps_02954 Sps_02956 Sps_02956 Sps_03132 Sps_03132 Sps_03543 Sps_03543 Sps_03594 Sps_03594 cysC cysC cysN cysN cysD cysD luxS luxS metE metE Sps_04796 Sps_04796 Sps_04803 Sps_04803 Sps_04804 Sps_04804 Sps_04805 Sps_04805 Sps_04806 Sps_04806 cysQ cysQ
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
glpERhodanese-related sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (102 aa)
Sps_00575Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. (392 aa)
Sps_00587GAF domain-containing protein; PFAM: GAF domain. (152 aa)
Sps_00645Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (296 aa)
Sps_00911PFAM: Aminotransferase class I and II. (397 aa)
Sps_01137Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (353 aa)
Sps_01394Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. (297 aa)
Sps_01864Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. (392 aa)
cysSPFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (459 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (314 aa)
Sps_02143PFAM: Flavodoxin. (154 aa)
mtnNMethylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)
cysHPhosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (261 aa)
cysISulfite reductase (NADPH) beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (577 aa)
Sps_02800Sulfite reductase (NADPH) alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (600 aa)
Sps_02954PFAM: Methylenetetrahydrofolate reductase; 'TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form'; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
Sps_02956Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. (386 aa)
Sps_03132'PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (six repeats)'; TIGRFAM: serine O-acetyltransferase. (261 aa)
Sps_03543Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
Sps_03594Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (six repeats); TIGRFAM: serine O-acetyltransferase. (273 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (220 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (477 aa)
cysDSulfate adenylyltransferase subunit 2; PFAM: Phosphoadenosine phosphosulfate reductase family; 'TIGRFAM: sulfate adenylyltransferase, small subunit'. (301 aa)
luxSS-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (169 aa)
metEMethionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
Sps_04796Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
Sps_04803PFAM: FAD-NAD(P)-binding. (606 aa)
Sps_04804PFAM: ParB-like nuclease domain. (142 aa)
Sps_04805PFAM: Pyridoxal-phosphate dependent enzyme; 'TIGRFAM: 2,3-diaminopropionate biosynthesis protein SbnA'. (312 aa)
Sps_048062,3-diaminopropionate biosynthesis protein SbnB; PFAM: Ornithine cyclodeaminase/mu-crystallin family; 'TIGRFAM: 2,3-diaminopropionate biosynthesis protein SbnB'. (337 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (271 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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