node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sps_02086 | Sps_02235 | Sps_02086 | Sps_02235 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. | 0.851 |
Sps_02086 | Sps_03227 | Sps_02086 | Sps_03227 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 0.733 |
Sps_02086 | ilvE | Sps_02086 | Sps_03125 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.733 |
Sps_02086 | leuB | Sps_02086 | Sps_03289 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.851 |
Sps_02086 | leuC | Sps_02086 | Sps_03287 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.879 |
Sps_02086 | leuD | Sps_02086 | Sps_03286 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.879 |
Sps_02235 | Sps_02086 | Sps_02235 | Sps_02086 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 0.851 |
Sps_02235 | leuA | Sps_02235 | Sps_03290 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.894 |
Sps_02235 | leuC | Sps_02235 | Sps_03287 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.926 |
Sps_02235 | leuD | Sps_02235 | Sps_03286 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.909 |
Sps_03227 | Sps_02086 | Sps_03227 | Sps_02086 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 0.733 |
Sps_03227 | ilvE | Sps_03227 | Sps_03125 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
Sps_03227 | leuA | Sps_03227 | Sps_03290 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.985 |
Sps_03227 | leuB | Sps_03227 | Sps_03289 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.441 |
Sps_03227 | leuC | Sps_03227 | Sps_03287 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.667 |
Sps_03227 | leuD | Sps_03227 | Sps_03286 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.456 |
ilvE | Sps_02086 | Sps_03125 | Sps_02086 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. | 0.733 |
ilvE | Sps_03227 | Sps_03125 | Sps_03227 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. | 0.900 |
ilvE | leuA | Sps_03125 | Sps_03290 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.987 |
ilvE | leuC | Sps_03125 | Sps_03287 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.575 |