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hutU hutU hutI hutI Sps_00050 Sps_00050 tdh tdh Sps_00596 Sps_00596 dadA dadA Sps_00691 Sps_00691 gcvH gcvH gcvP gcvP Sps_00702 Sps_00702 Sps_00703 Sps_00703 Sps_00705 Sps_00705 astE astE Sps_00789 Sps_00789 Sps_00790 Sps_00790 Sps_00843 Sps_00843 Sps_01310 Sps_01310 Sps_01074 Sps_01074 speA speA Sps_01497 Sps_01497 Sps_01572 Sps_01572 Sps_01627 Sps_01627 astB astB kynA kynA Sps_02041 Sps_02041 Sps_02042 Sps_02042 Sps_02086 Sps_02086 Sps_02099 Sps_02099 Sps_02100 Sps_02100 Sps_02108 Sps_02108 Sps_02941 Sps_02941 Sps_03208 Sps_03208 Sps_03336 Sps_03336 dtd dtd Sps_03403 Sps_03403 Sps_03666 Sps_03666 Sps_04487 Sps_04487 Sps_04488 Sps_04488 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT gcvT Sps_05022 Sps_05022 astD astD Sps_05067 Sps_05067 hutH hutH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa)
hutIImidazolonepropionase; PFAM: Amidohydrolase; TIGRFAM: imidazolonepropionase. (408 aa)
Sps_00050Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; WD40-like Beta Propeller Repeat; Amidohydrolase family. (1081 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
Sps_00596PFAM: Bacterial NAD-glutamate dehydrogenase. (1612 aa)
dadAD-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (417 aa)
Sps_00691PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein. (375 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
Sps_00702PFAM: FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form'. (417 aa)
Sps_00703'PFAM: Sarcosine oxidase, delta subunit family'; 'TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form'. (104 aa)
Sps_00705'PFAM: Sarcosine oxidase, gamma subunit family'; 'TIGRFAM: sarcosine oxidase, gamma subunit family, heterotetrameric form'. (236 aa)
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (344 aa)
Sps_00789Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit; PFAM: Dehydrogenase E1 component. (392 aa)
Sps_00790Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; 'PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (320 aa)
Sps_00843'PFAM: homogentisate 1,2-dioxygenase'; 'TIGRFAM: homogentisate 1,2-dioxygenase'. (433 aa)
Sps_01310Hypothetical protein; PFAM: Serine dehydratase alpha chain; Belongs to the UPF0597 family. (424 aa)
Sps_01074'PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain'; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa)
Sps_01497Tryptophanase; PFAM: Beta-eliminating lyase; 'TIGRFAM: tryptophanase, leader peptide-associated'. (465 aa)
Sps_01572HIT family hydrolase, diadenosine tetraphosphate hydrolase; PFAM: HIT domain. (118 aa)
Sps_016272-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa)
astBSuccinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (445 aa)
kynATryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (281 aa)
Sps_02041PFAM: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; NAD binding domain of 6-phosphogluconate dehydrogenase; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (312 aa)
Sps_02042PFAM: Enoyl-CoA hydratase/isomerase family; 2-enoyl-CoA Hydratase C-terminal region. (377 aa)
Sps_02086hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. (296 aa)
Sps_02099Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; Amidohydrolase family. (1027 aa)
Sps_02100Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase. (454 aa)
Sps_02108Enolase superfamily enzyme related to L-alanine-DL-glutamate epimerase; 'PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase / muconate lactonizing enzyme, N-terminal domain'. (355 aa)
Sps_02941Putative dehydrogenase; PFAM: FAD dependent oxidoreductase. (375 aa)
Sps_03208'PFAM: Alanine dehydrogenase/PNT, N-terminal domain'. (368 aa)
Sps_03336Histidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: phenylalanine ammonia-lyase. (520 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa)
Sps_03403glycine/D-amino acid oxidase, deaminating; PFAM: FAD dependent oxidoreductase. (421 aa)
Sps_03666Phenylalanine 4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; 'TIGRFAM: phenylalanine-4-hydroxylase, monomeric form'. (265 aa)
Sps_04487Hypothetical protein; PFAM: Amidohydrolase family. (70 aa)
Sps_04488Hypothetical protein; PFAM: Amidohydrolase. (114 aa)
gcvP-2Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
Sps_05022Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1059 aa)
astDSuccinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (486 aa)
Sps_05067PFAM: Arginine N-succinyltransferase beta subunit; TIGRFAM: arginine N-succinyltransferase; arginine and ornithine succinyltransferase subunits. (339 aa)
hutHHistidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: histidine ammonia-lyase. (510 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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