STRINGSTRING
Sps_01091 Sps_01091 Sps_00769 Sps_00769 Sps_00648 Sps_00648 Sps_00563 Sps_00563 Sps_00449 Sps_00449 murB murB Sps_00147 Sps_00147 tdh tdh aroE aroE fadB fadB Sps_04636 Sps_04636 maeA maeA Sps_04326 Sps_04326 Sps_04287 Sps_04287 Sps_04125 Sps_04125 guaB guaB leuB leuB Sps_03218 Sps_03218 pdxA pdxA Sps_03128 Sps_03128 Sps_02993 Sps_02993 Sps_02955 Sps_02955 Sps_02853 Sps_02853 mdh mdh Sps_02407 Sps_02407 Sps_02314 Sps_02314 Sps_02235 Sps_02235 dxr dxr gpsA gpsA Sps_05361 Sps_05361 Sps_05097 Sps_05097 Sps_04933 Sps_04933 Sps_02076 Sps_02076 Sps_02041 Sps_02041 Sps_01974 Sps_01974 fadJ fadJ pdxB pdxB hisD hisD Sps_01296 Sps_01296 zwf zwf
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sps_01091'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (413 aa)
Sps_00769Alcohol dehydrogenase AdhE; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa)
Sps_00648Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (356 aa)
Sps_00563PFAM: Monomeric isocitrate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type'; Belongs to the monomeric-type IDH family. (741 aa)
Sps_00449Dihydrofolate reductase; PFAM: RibD C-terminal domain. (186 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (343 aa)
Sps_00147dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (288 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa)
fadBFatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa)
Sps_04636Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (323 aa)
maeA'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (562 aa)
Sps_04326Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (321 aa)
Sps_04287PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (386 aa)
Sps_04125Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
Sps_03218PFAM: Iron-containing alcohol dehydrogenase. (385 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (328 aa)
Sps_03128Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (521 aa)
Sps_02993dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (306 aa)
Sps_02955Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (795 aa)
Sps_02853'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (409 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
Sps_02407Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
Sps_02314Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (382 aa)
Sps_02235PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. (335 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (395 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
Sps_05361'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (415 aa)
Sps_05097Phosphoglycerate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain'. (308 aa)
Sps_04933Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (329 aa)
Sps_020766-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (517 aa)
Sps_02041PFAM: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; NAD binding domain of 6-phosphogluconate dehydrogenase; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (312 aa)
Sps_01974Nucleoside-diphosphate-sugar epimerase; PFAM: 3-beta hydroxysteroid dehydrogenase/isomerase family. (358 aa)
fadJFatty oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (708 aa)
pdxB4-phosphoerythronate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (387 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
Sps_01296Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (389 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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