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| | Sps_04735 | Hypothetical protein; 'PFAM: Uncharacterized ACR, YhhQ family COG1738'; TIGRFAM: conserved hypothetical integral membrane protein. (278 aa) |
| | Sps_04783 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (217 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (539 aa) |
| | Sps_04785 | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (184 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (257 aa) |
| | cobT | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (342 aa) |
| | Sps_04806 | 2,3-diaminopropionate biosynthesis protein SbnB; PFAM: Ornithine cyclodeaminase/mu-crystallin family; 'TIGRFAM: 2,3-diaminopropionate biosynthesis protein SbnB'. (337 aa) |
| | Sps_04856 | PFAM: 5-formyltetrahydrofolate cyclo-ligase family; 'TIGRFAM: 5,10-methenyltetrahydrofolate synthetase'. (207 aa) |
| | Sps_04892 | RNA-directed DNA polymerase; 'PFAM: Group II intron, maturase-specific domain; Reverse transcriptase (RNA-dependent DNA polymerase); N-terminal domain of reverse transcriptase'. (490 aa) |
| | Sps_04897 | Heme utilization protein HuvX; PFAM: Haem utilisation ChuX/HutX; TIGRFAM: putative heme utilization carrier protein HutX. (176 aa) |
| | Sps_04905 | Coproporphyrinogen III oxidase, anaerobic; PFAM: Radical SAM superfamily; TIGRFAM: putative heme utilization radical SAM enzyme HutW. (459 aa) |
| | Sps_04986 | 'PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)'; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (163 aa) |
| | Sps_04995 | PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | Sps_05033 | 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (205 aa) |
| | Sps_05174 | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa) |
| | priB | Restart primosome assembly protein PriB; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (101 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | Sps_05208 | RNA polymerase, sigma 54 subunit, RpoN/SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (492 aa) |
| | priA | Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (731 aa) |
| | Sps_05383 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); 'PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain'; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (305 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | Sps_05426 | Competence/damage-inducible protein cinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; 'TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; amidohydrolase, PncC family; molybdenum cofactor synthesis domain'. (424 aa) |
| | ribB-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | Sps_05475 | Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (414 aa) |
| | Sps_05476 | (molybdopterin synthase) sulfurylase; PFAM: MoeZ/MoeB domain; ThiF family; TIGRFAM: molybdopterin synthase sulfurylase MoeB. (255 aa) |
| | Sps_05481 | 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (177 aa) |
| | Sps_05497 | Molybdopterin synthase subunit MoaE; PFAM: MoaE protein. (155 aa) |
| | Sps_05498 | PFAM: ThiS family; 'TIGRFAM: molybdopterin converting factor, subunit 1, non-archaeal'. (83 aa) |
| | moaC | Cyclic pyranopterin monophosphate synthase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | moaA-2 | Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | Sps_05508 | PFAM: Acetyltransferase (GNAT) domain. (151 aa) |
| | Sps_05512 | Fe-S oxidoreductase, coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily. (445 aa) |
| | Sps_05526 | PFAM: Protein of unknown function (DUF3305). (157 aa) |
| | fdhD | Uncharacterized protein required for formate dehydrogenase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (280 aa) |
| | Sps_05571 | Type III secretion apparatus H+-transporting two-sector ATPase; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: type III secretion apparatus H+-transporting two-sector ATPase; ATPase, FliI/YscN family'. (448 aa) |
| | Sps_05619 | PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (177 aa) |
| | cyoE-2 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (310 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (458 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | Proton translocating ATP synthase, F1 alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | ATP synthase, F1 delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpB | F0F1-type ATP synthase, alpha subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (264 aa) |
| | atpE | ATP synthase, F0 subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (83 aa) |
| | Sps_00035 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | Sps_00060 | PFAM: Flavodoxin domain. (175 aa) |
| | Sps_00062 | PFAM: Flavodoxin domain. (179 aa) |
| | hemF | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (307 aa) |
| | Sps_00090 | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; 'PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family'. (240 aa) |
| | Sps_00113 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (444 aa) |
| | Sps_00130 | Oxygen-independent coproporphyrinogen III oxidase; PFAM: HemN C-terminal domain; Radical SAM superfamily; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (458 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (917 aa) |
| | Sps_00147 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (288 aa) |
| | Sps_00149 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | hldD | ADP-glyceromanno-heptose 6-epimerase precursor; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (317 aa) |
| | hldE | D-heptose-7- phosphate 1-kinase,D-heptose-1-phosphate adenylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa) |
| | Sps_00167 | Molybdopterin-guanine dinucleotide biosynthesis protein MobB; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (599 aa) |
| | mobA | Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (196 aa) |
| | Sps_00174 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (213 aa) |
| | Sps_00201 | PFAM: Protein of unknown function (DUF3137). (336 aa) |
| | Sps_00212 | PFAM: 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily. (276 aa) |
| | bioH | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (261 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (304 aa) |
| | Sps_00255 | PFAM: Cytochrome oxidase assembly protein. (327 aa) |
| | Sps_00268 | cob(II)yrinic acid a,c-diamide reductase; PFAM: Nitroreductase family; 'TIGRFAM: 5,6-dimethylbenzimidazole synthase'. (219 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (286 aa) |
| | coaA | PFAM: Phosphoribulokinase / Uridine kinase family; 'TIGRFAM: pantothenate kinase, bacterial type'. (316 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (183 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1343 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1408 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa) |
| | Sps_00447 | PFAM: 6-pyruvoyl tetrahydropterin synthase. (293 aa) |
| | Sps_00449 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (186 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; 'PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain'; TIGRFAM: phosphoribosylaminoimidazole synthetase. (345 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | Sps_00558 | PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa) |
| | Sps_00643 | Dinucleotide-utilizing enzyme; PFAM: ThiS family; MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. (473 aa) |
| | Sps_00663 | PFAM: Exonuclease; 'TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family'. (206 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | Sps_00758 | Aminodeoxychorismate synthase, subunit I; 'PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region'; 'TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade'. (464 aa) |
| | Sps_00776 | Putative HD superfamily hydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (195 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (355 aa) |
| | Sps_00808 | Ribonucleoside-diphosphate reductase class Ia beta subunit; 'PFAM: Ribonucleotide reductase, small chain'. (376 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | cmk | PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (230 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa) |
| | Sps_00903 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); 'PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain'; 'TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I'; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | Sps_00985 | ATPase FliI/YscN family; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (442 aa) |
| | Sps_01022 | nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: Domain of unknown function (DUF4113); impB/mucB/samB family C-terminal domain; impB/mucB/samB family. (417 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | Sps_01084 | PFAM: Lumazine binding domain; 'TIGRFAM: riboflavin synthase, alpha subunit'. (204 aa) |
| | Sps_01095 | Hypothetical protein; PFAM: Domain of unknown function (DUF336). (144 aa) |
| | Sps_01099 | PFAM: Ornithine cyclodeaminase/mu-crystallin family. (332 aa) |
| | queE | Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa) |
| | Sps_01179 | Tyrosine lyase ThiH; PFAM: Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (371 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa) |
| | Sps_01181 | Sulfur carrier protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (80 aa) |
| | Sps_01182 | Dinucleotide-utilizing enzyme; PFAM: MoeZ/MoeB domain; ThiF family. (275 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (525 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (658 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (242 aa) |
| | napA | Periplasmic nitrate reductase subunit NapA apoprotein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (829 aa) |
| | purC | PFAM: SAICAR synthetase; 'TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type'. (368 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa) |
| | Sps_01387 | 'PFAM: DNA polymerase III, delta subunit'; 'TIGRFAM: DNA polymerase III, delta' subunit'. (304 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | Sps_01390 | PFAM: Aminotransferase class IV; TIGRFAM: aminodeoxychorismate lyase. (275 aa) |
| | udk | PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase. (211 aa) |
| | Sps_01420 | Hypothetical protein. (222 aa) |
| | Sps_01534 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (234 aa) |
| | Sps_01565 | PFAM: Phosphotransferase enzyme family. (349 aa) |
| | Sps_01594 | 'PFAM: Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain'. (400 aa) |
| | Sps_01595 | uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. (288 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (231 aa) |
| | Sps_01602 | Methyltransferase family protein; PFAM: Methyltransferase domain; TIGRFAM: malonyl-acyl carrier protein O-methyltransferase BioC. (262 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (354 aa) |
| | Sps_01605 | PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (331 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | Sps_01671 | 'PFAM: DNA polymerase III tau subunit V interacting with alpha; DNA polymerase III subunits gamma and tau domain III; DNA polymerase III, delta subunit'; 'TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau'. (940 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | Sps_01691 | 'PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region'; 'TIGRFAM: anthranilate synthase component I, proteobacterial subset'. (529 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (491 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | Sps_01714 | Putative MobA-like protein; PFAM: MobA-like NTP transferase domain. (218 aa) |
| | Sps_01739 | PFAM: SnoaL-like domain. (119 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | Sps_01755 | Folylpolyglutamate synthase/dihydrofolate synthase; 'PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain'; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (423 aa) |
| | pdxB | 4-phosphoerythronate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (387 aa) |
| | Sps_01760 | Phosphopantetheinyl transferase component of siderophore synthetase; PFAM: 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily. (229 aa) |
| | Sps_01769 | Salicylate synthase; PFAM: chorismate binding enzyme; TIGRFAM: salicylate synthase. (472 aa) |
| | Sps_01781 | Hypothetical protein; PFAM: ATP-NAD kinase. (374 aa) |
| | Sps_01800 | 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | Sps_01801 | PFAM: Protein of unknown function (DUF3379). (234 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa) |
| | Sps_01817 | Ribonucleoside-triphosphate reductase class III activase subunit; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (157 aa) |
| | Sps_01855 | 'PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain'. (811 aa) |
| | Sps_01858 | Restart primosome assembly protein PriC; PFAM: Primosomal replication protein priB and priC. (224 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | Sps_02077 | propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa) |
| | tdk | PFAM: Thymidine kinase. (192 aa) |
| | Sps_02117 | PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; Helix-hairpin-helix motif; TIGRFAM: DNA-directed DNA polymerase III (polc). (1157 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (285 aa) |
| | Sps_02209 | PFAM: Acetyltransferase (GNAT) domain. (164 aa) |
| | thiI | (ThiS-adenylate) sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | nadK | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | Sps_02335 | Putative transcriptional regulator; 'PFAM: Uncharacterized ACR, COG1678'; Belongs to the UPF0301 (AlgH) family. (186 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | Sps_02345 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa) |
| | Sps_02387 | PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (311 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (245 aa) |
| | Sps_02441 | RNA polymerase, sigma-24 subunit, RpoE; 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma factor RpoE'; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | Sps_02442 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (537 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (283 aa) |
| | Sps_02460 | PFAM: CobD/Cbib protein. (327 aa) |
| | Sps_02485 | Flagellar biosynthesis/type III secretory pathway ATPase; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (420 aa) |
| | hemL | PFAM: Aminotransferase class-III; 'TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase'. (428 aa) |
| | Sps_02546 | 'PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)'; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (173 aa) |
| | Sps_02547 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (127 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (575 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (610 aa) |
| | Sps_02565 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | Sps_02612 | Putative phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (188 aa) |
| | Sps_02632 | Radical SAM protein, TatD family-associated; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; 'TIGRFAM: radical SAM protein, TatD family-associated'. (205 aa) |
| | Sps_02640 | Erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (340 aa) |
| | Sps_02665 | Putative HD superfamily hydrolase; PFAM: HD domain. (199 aa) |
| | Sps_02672 | Putative ATPase; PFAM: AAA domain. (392 aa) |
| | Sps_02690 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | Sps_02782 | PFAM: Flavodoxin domain. (173 aa) |
| | Sps_02789 | uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (292 aa) |
| | Sps_02836 | Retron-type reverse transcriptase; 'PFAM: Group II intron, maturase-specific domain; Reverse transcriptase (RNA-dependent DNA polymerase)'. (448 aa) |
| | Sps_02865 | Putative secreted hydrolase; PFAM: Hydroxyneurosporene synthase (CrtC). (368 aa) |
| | napA-2 | Periplasmic nitrate reductase subunit NapA apoprotein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (827 aa) |
| | Sps_02949 | PFAM: Cysteine-rich CWC. (75 aa) |
| | Sps_02993 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (306 aa) |
| | Sps_03033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Sps_03058 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (338 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (422 aa) |
| | Sps_03081 | PFAM: Haloacid dehalogenase-like hydrolase; 'TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E'. (240 aa) |
| | Sps_03088 | 'PFAM: Adenylate cyclase, class-I; Adenylate cyclase NT domain'; Belongs to the adenylyl cyclase class-1 family. (807 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | Sps_03090 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (216 aa) |
| | Sps_03092 | PFAM: HemY protein N-terminus; TIGRFAM: heme biosynthesis-associated TPR protein. (389 aa) |
| | Sps_03146 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (252 aa) |
| | Sps_03155 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (152 aa) |
| | purH | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (529 aa) |
| | purD | Phosphoribosylamine--glycine ligase; 'PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain'; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | Sps_03241 | PFAM: Nitrous oxide-stimulated promoter. (131 aa) |
| | Sps_03256 | Mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; mannose-6-phosphate isomerase, type 2. (479 aa) |
| | Sps_03302 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | folE | PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (219 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (94 aa) |
| | Sps_03318 | (p)ppGpp synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa) |
| | Sps_03333 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme. (454 aa) |
| | Sps_03399 | Retron-type reverse transcriptase; 'PFAM: Group II intron, maturase-specific domain; Reverse transcriptase (RNA-dependent DNA polymerase)'; Group II catalytic intron. (446 aa) |
| | Sps_03427 | Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase. (946 aa) |
| | Sps_03509 | Metal-dependent hydrolase, beta-lactamase superfamily II; PFAM: Metallo-beta-lactamase superfamily. (281 aa) |
| | Sps_03531 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (155 aa) |
| | Sps_03544 | 'PFAM: Bacterial regulatory proteins, tetR family'. (230 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | Sps_03568 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | Sps_03603 | Siroheme synthase, N-terminal domain; PFAM: Sirohaem biosynthesis protein central; Putative NAD(P)-binding; Sirohaem synthase dimerisation region; 'TIGRFAM: siroheme synthase, N-terminal domain'. (303 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (374 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (345 aa) |
| | Sps_03665 | PFAM: Pterin 4 alpha carbinolamine dehydratase. (112 aa) |
| | Sps_03718 | PFAM: NAD dependent epimerase/dehydratase family. (317 aa) |
| | Sps_03722 | dTDP-4-dehydrorhamnose 3,5-epimerase-like enzyme. (143 aa) |
| | Sps_03723 | CDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; 'TIGRFAM: CDP-glucose 4,6-dehydratase'. (366 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa) |
| | Sps_03780 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (446 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1293 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa) |
| | Sps_03844 | PFAM: Protein of unknown function (DUF3820). (73 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | pyrB | 'PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain'; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | Sps_03937 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa) |
| | Sps_04058 | 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (204 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | rpoS | RNA polymerase, sigma 38 subunit, RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (323 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (134 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (160 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (367 aa) |
| | Sps_04124 | PFAM: Lumazine binding domain; 'TIGRFAM: riboflavin synthase, alpha subunit'. (220 aa) |
| | Sps_04125 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa) |
| | Sps_04136 | PFAM: Metallo-beta-lactamase superfamily. (126 aa) |
| | Sps_04212 | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (330 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (499 aa) |
| | Sps_04255 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | carB | 'PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain'; 'TIGRFAM: carbamoyl-phosphate synthase, large subunit'; Belongs to the CarB family. (1072 aa) |
| | carA | 'PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I'; 'TIGRFAM: carbamoyl-phosphate synthase, small subunit'; Belongs to the CarA family. (381 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (424 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | dinB | nucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (353 aa) |
| | Sps_04308 | Transcriptional regulator, BolA protein family; PFAM: BolA-like protein; Belongs to the BolA/IbaG family. (99 aa) |
| | Sps_04312 | RNA-directed DNA polymerase; 'PFAM: Group II intron, maturase-specific domain; Reverse transcriptase (RNA-dependent DNA polymerase); N-terminal domain of reverse transcriptase'. (518 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | Sps_04365 | Putative Mg2+ and Co2+ transporter CorC; PFAM: CBS domain; Transporter associated domain. (291 aa) |
| | Sps_04371 | DNA polymerase III, delta subunit; 'PFAM: Processivity clamp loader gamma complex DNA pol III C-term; DNA polymerase III, delta subunit'; 'TIGRFAM: DNA polymerase III, delta subunit'. (346 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (211 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | Sps_04384 | Hypothetical protein. (116 aa) |
| | Sps_04404 | RNA polymerase, sigma-24 subunit, RpoE; 'PFAM: Sigma-70, region 4; Sirohaem synthase dimerisation region; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | add | PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (331 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (424 aa) |
| | Sps_04449 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (143 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | Sps_04540 | 'PFAM: Sigma-70, region 4; Sigma-70 region 2'; 'TIGRFAM: RNA polymerase sigma factor, sigma-70 family'; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | Sps_04548 | PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain. (622 aa) |
| | Sps_04565 | PFAM: Aminotransferase class-III; 'TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | Sps_04600 | 'PFAM: DNA polymerase III chi subunit, HolC'. (156 aa) |
| | Sps_04622 | 'PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (747 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (328 aa) |
| | apaG | Uncharacterized protein affecting Mg2+/Co2+ transport; PFAM: Protein of unknown function (DUF525). (126 aa) |
