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| | Sps_03302 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | Sps_03336 | Histidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: phenylalanine ammonia-lyase. (520 aa) |
| | Sps_03405 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (304 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | Sps_03568 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (469 aa) |
| | rpmH | PFAM: Ribosomal protein L34; 'TIGRFAM: ribosomal protein L34, bacterial type'; Belongs to the bacterial ribosomal protein bL34 family. (45 aa) |
| | glyS | PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; 'TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit'. (689 aa) |
| | glyQ | PFAM: Glycyl-tRNA synthetase alpha subunit; 'TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit'. (287 aa) |
| | Sps_00050 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; WD40-like Beta Propeller Repeat; Amidohydrolase family. (1081 aa) |
| | Sps_00053 | Cys-tRNA(Pro) deacylase; PFAM: Aminoacyl-tRNA editing domain; TIGRFAM: Cys-tRNA(Pro) deacylase; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (170 aa) |
| | Sps_00181 | 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain'; 'TIGRFAM: glutathione-disulfide reductase, animal/bacterial'. (451 aa) |
| | Sps_00187 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (216 aa) |
| | Sps_00212 | PFAM: 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily. (276 aa) |
| | bioH | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (261 aa) |
| | Sps_00274 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (275 aa) |
| | tuf | Translation elongation factor TU; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (409 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa) |
| | rplL | LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | rpsL | SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (698 aa) |
| | Sps_00362 | PFAM: Elongation factor Tu GTP binding domain. (89 aa) |
| | Sps_00363 | PFAM: Elongation factor Tu C-terminal domain; Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; TIGRFAM: translation elongation factor TU. (303 aa) |
| | rpsJ | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rplC | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (212 aa) |
| | rplD | LSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (201 aa) |
| | rplW | LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa) |
| | rplB | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa) |
| | rpsS | Ribosomal protein S19, bacterial/organelle; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplV | LSU ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (110 aa) |
| | rpsC | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (229 aa) |
| | rplP | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa) |
| | rpmC | PFAM: Ribosomal L29 protein; TIGRFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (63 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (82 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | LSU ribosomal protein L24P; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (104 aa) |
| | rplE | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsN | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsH | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rplF | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (176 aa) |
| | rplR | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (116 aa) |
| | rpsE | Ribosomal protein S5, bacterial/organelle type; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (167 aa) |
| | rpmD | PFAM: Ribosomal protein L30p/L7e; 'TIGRFAM: ribosomal protein L30, bacterial/organelle'. (61 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa) |
| | rpsK | SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (130 aa) |
| | rpsD | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa) |
| | rplQ | PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17. (131 aa) |
| | Sps_00437 | Elongation factor P-like protein YeiP; 'PFAM: Elongation factor P, C-terminal; Elongation factor P (EF-P) KOW-like domain; Elongation factor P (EF-P) OB domain'; TIGRFAM: translation elongation factor P; elongation factor P-like protein YeiP. (192 aa) |
| | Sps_00471 | 'PFAM: Glutathione S-transferase, N-terminal domain'. (118 aa) |
| | Sps_00474 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (128 aa) |
| | Sps_00477 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (116 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | Sps_00528 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (142 aa) |
| | infA | Bacterial translation initiation factor 1 (bIF-1); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rplY | LSU ribosomal protein L25P; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (95 aa) |
| | fusA-2 | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (697 aa) |
| | asnS | 'PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain'; TIGRFAM: asparaginyl-tRNA synthetase. (466 aa) |
| | efp | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (187 aa) |
| | Sps_00805 | PFAM: Peptidase family S49; 'TIGRFAM: signal peptide peptidase SppA, 36K type; signal peptide peptidase SppA, 67K type'. (613 aa) |
| | Sps_00817 | SSU ribosomal protein S1P; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (555 aa) |
| | Sps_00965 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (299 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | rplT | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | rpmI | PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | infC | Bacterial translation initiation factor 3 (bIF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (153 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (642 aa) |
| | Sps_01106 | PFAM: Ureidoglycolate hydrolase. (172 aa) |
| | Sps_01108 | PFAM: OHCU decarboxylase; TIGRFAM: OHCU decarboxylase. (166 aa) |
| | alc | PFAM: Allantoicase repeat; TIGRFAM: allantoicase; Belongs to the allantoicase family. (352 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (595 aa) |
| | Sps_01171 | Hypothetical protein; PFAM: Putative ATP-dependant zinc protease. (247 aa) |
| | def-2 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (163 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; PFAM: tRNA synthetase B5 domain; Ferredoxin-fold anticodon binding domain; B3/4 domain; Putative tRNA binding domain; 'TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial'; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (795 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; 'PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain'; 'TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit'; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (327 aa) |
| | Sps_01335 | Hypothetical protein; PFAM: Putative ATP-dependant zinc protease. (118 aa) |
| | Sps_01338 | Hypothetical protein; PFAM: Putative ATP-dependant zinc protease. (195 aa) |
| | Sps_01359 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (159 aa) |
| | rpmF | PFAM: Ribosomal L32p protein family; TIGRFAM: ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (56 aa) |
| | Sps_01377 | Ribosome biogenesis GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (312 aa) |
| | Sps_01390 | PFAM: Aminotransferase class IV; TIGRFAM: aminodeoxychorismate lyase. (275 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (694 aa) |
| | Sps_01403 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (216 aa) |
| | Sps_01414 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (336 aa) |
| | Sps_01434 | PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase. (582 aa) |
| | Sps_01471 | Hypothetical protein. (920 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (231 aa) |
| | Sps_01602 | Methyltransferase family protein; PFAM: Methyltransferase domain; TIGRFAM: malonyl-acyl carrier protein O-methyltransferase BioC. (262 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (354 aa) |
| | Sps_01605 | PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa) |
| | Sps_01627 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa) |
| | Sps_01746 | PFAM: Glyoxalase-like domain; TIGRFAM: lactoylglutathione lyase family protein. (194 aa) |
| | Sps_01755 | Folylpolyglutamate synthase/dihydrofolate synthase; 'PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain'; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (423 aa) |
| | Sps_01760 | Phosphopantetheinyl transferase component of siderophore synthetase; PFAM: 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily. (229 aa) |
| | Sps_01770 | Peptide arylation enzyme; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain; 'TIGRFAM: 2,3-dihydroxybenzoate-AMP ligase'. (552 aa) |
| | Sps_01841 | Hypothetical protein; PFAM: S4 domain. (77 aa) |
| | cysS | PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (459 aa) |
| | glnS | 'PFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-codon binding domain'; TIGRFAM: glutaminyl-tRNA synthetase. (556 aa) |
| | Sps_01955 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (127 aa) |
| | Sps_02059 | PFAM: Acyl-CoA thioesterase; TIGRFAM: acyl-CoA thioesterase II. (288 aa) |
| | Sps_02067 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (256 aa) |
| | Sps_02069 | Hypothetical protein; PFAM: Sulfatase-modifying factor enzyme 1. (344 aa) |
| | Sps_02077 | propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa) |
| | Sps_02099 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; Amidohydrolase family. (1027 aa) |
| | Sps_02100 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase. (454 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (569 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | tsf | Translation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (282 aa) |
| | rpsB | PFAM: Ribosomal protein S2; 'TIGRFAM: ribosomal protein S2, bacterial type'; Belongs to the universal ribosomal protein uS2 family. (242 aa) |
| | Sps_02181 | 'PFAM: Elongation Factor G, domain II; Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV'; TIGRFAM: translation elongation factor EF-G; small GTP-binding protein domain. (693 aa) |
| | Sps_02291 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; Belongs to the GST superfamily. (222 aa) |
| | Sps_02319 | Hypothetical protein. (72 aa) |
| | Sps_02322 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (122 aa) |
| | Sps_02334 | PFAM: Translation initiation factor SUI1; 'TIGRFAM: translation initation factor SUI1, putative, prokaryotic'. (109 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (924 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (88 aa) |
| | rplS | LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (117 aa) |
| | rpsP | PFAM: Ribosomal protein S16; TIGRFAM: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (83 aa) |
| | Sps_02436 | 'PFAM: Peptidase S24-like; Signal peptidase, peptidase S26'; 'TIGRFAM: signal peptidase I, bacterial type'; Belongs to the peptidase S26 family. (305 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (596 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (398 aa) |
| | Sps_02546 | 'PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)'; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (173 aa) |
| | Sps_02547 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (127 aa) |
| | rpsU | PFAM: Ribosomal protein S21; TIGRFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (71 aa) |
| | Sps_02565 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | def-3 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (166 aa) |
| | rpmA | PFAM: Ribosomal L27 protein; TIGRFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (84 aa) |
| | rplU | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | Sps_02759 | Zn-dependent hydrolase, glyoxylase; PFAM: Metallo-beta-lactamase superfamily; Rhodanese-like domain. (347 aa) |
| | Sps_02760 | Hypothetical protein; PFAM: Domain of unknown function. (72 aa) |
| | Sps_02817 | Hypothetical protein. (112 aa) |
| | Sps_02818 | Hypothetical protein; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (257 aa) |
| | Sps_02844 | Dipeptidyl-peptidase 7; Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. (718 aa) |
| | rimK | SSU ribosomal protein S6P modification protein; PFAM: RimK-like ATP-grasp domain; Putative ATP-dependant zinc protease; 'TIGRFAM: alpha-L-glutamate ligase, RimK family'; Belongs to the RimK family. (464 aa) |
| | gshB | 'PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain'; 'TIGRFAM: glutathione synthetase, prokaryotic'; Belongs to the prokaryotic GSH synthase family. (317 aa) |
| | Sps_05621 | PFAM: HI0933-like protein; 'TIGRFAM: flavoprotein, HI0933 family'. (394 aa) |
| | Sps_05599 | Siderophore synthetase component; PFAM: Ferric iron reductase FhuF-like transporter; IucA / IucC family. (610 aa) |
| | Sps_05597 | Siderophore synthetase component; PFAM: Ferric iron reductase FhuF-like transporter; IucA / IucC family. (588 aa) |
| | Sps_05596 | PFAM: ATP-grasp domain. (395 aa) |
| | hutI | Imidazolonepropionase; PFAM: Amidohydrolase; TIGRFAM: imidazolonepropionase. (408 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa) |
| | hutH | Histidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: histidine ammonia-lyase. (510 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa) |
| | argS | arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (581 aa) |
| | rpmE | LSU ribosomal protein L31P; Binds the 23S rRNA. (70 aa) |
| | panB-2 | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | rplM | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (143 aa) |
| | rpsI | PFAM: Ribosomal protein S9/S16; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rpsF | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (140 aa) |
| | rpsR | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | rplI | LSU ribosomal protein L9P; Binds to the 23S rRNA. (150 aa) |
| | Sps_05175 | Dipeptidyl-peptidase 7; PFAM: Peptidase S46. (740 aa) |
| | Sps_05157 | PFAM: Pyocin activator protein PrtN. (83 aa) |
| | Sps_05073 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; Belongs to the GST superfamily. (209 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | Sps_04986 | 'PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)'; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (163 aa) |
| | gluQ | Glutamyl-queuosine tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (290 aa) |
| | prfB | Bacterial peptide chain release factor 2 (bRF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (352 aa) |
| | lysS | 'PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain'; 'TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial'; Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | nagB | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (263 aa) |
| | Sps_04622 | 'PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (747 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (973 aa) |
| | Sps_04572 | 'PFAM: Glutathione S-transferase, N-terminal domain'. (198 aa) |
| | Sps_04567 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (232 aa) |
| | Sps_04566 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (219 aa) |
| | Sps_04562 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (285 aa) |
| | Sps_04551 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'. (219 aa) |
| | Sps_04511 | Hypothetical protein. (835 aa) |
| | Sps_04488 | Hypothetical protein; PFAM: Amidohydrolase. (114 aa) |
| | Sps_04487 | Hypothetical protein; PFAM: Amidohydrolase family. (70 aa) |
| | Sps_04415 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; Belongs to the GST superfamily. (207 aa) |
| | leuS | 'PFAM: Leucyl-tRNA synthetase, Domain 2; tRNA synthetases class I (I, L, M and V); Anticodon-binding domain of tRNA'; 'TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family'; Belongs to the class-I aminoacyl-tRNA synthetase family. (863 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (194 aa) |
| | prfA | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (361 aa) |
| | Sps_04326 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (321 aa) |
| | Sps_04255 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (499 aa) |
| | infB | Bacterial translation initiation factor 2 (bIF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (892 aa) |
| | rpsO | SSU ribosomal protein S15P; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | prfC | Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (526 aa) |
| | Sps_04165 | 'PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T)'; TIGRFAM: threonyl-tRNA synthetase. (392 aa) |
| | Sps_04134 | PFAM: ABC transporter; 'TIGRFAM: ATP-binding cassette protein, ChvD family'. (554 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (874 aa) |
| | gshA | PFAM: Glutamate-cysteine ligase; TIGRFAM: glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (535 aa) |
| | Sps_03948 | PFAM: OHCU decarboxylase; TIGRFAM: OHCU decarboxylase. (171 aa) |
| | Sps_03941 | Amidase, hydantoinase/carbamoylase family; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; 'TIGRFAM: amidase, hydantoinase/carbamoylase family'. (409 aa) |
| | Sps_03937 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa) |
| | Sps_03905 | Hypothetical protein. (155 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (165 aa) |
| | hisS | PFAM: Anticodon binding domain; Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase. (424 aa) |
| | Sps_03822 | PFAM: TfoX C-terminal domain. (89 aa) |
| | Sps_03816 | Hypothetical protein. (189 aa) |
| | Sps_03741 | methionyl-tRNA formyltransferase; 'PFAM: Formyl transferase; Formyl transferase, C-terminal domain'. (295 aa) |
| | Sps_03738 | methionyl-tRNA formyltransferase; 'PFAM: Formyl transferase; Formyl transferase, C-terminal domain'. (310 aa) |
| | Sps_03662 | Maleylacetoacetate isomerase; 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; TIGRFAM: maleylacetoacetate isomerase. (218 aa) |
| | Sps_02987 | Hypothetical protein. (134 aa) |
| | Sps_03030 | PFAM: RF-1 domain. (138 aa) |
| | Sps_03033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Sps_03192 | PFAM: Peptidase S24-like; 'TIGRFAM: signal peptidase I, bacterial type'; Belongs to the peptidase S26 family. (216 aa) |
| | Sps_03216 | 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; Belongs to the GST superfamily. (208 aa) |
| | rpmG | PFAM: Ribosomal protein L33; 'TIGRFAM: ribosomal protein L33, bacterial type'; Belongs to the bacterial ribosomal protein bL33 family. (57 aa) |
| | rpmB | LSU ribosomal protein L28P; PFAM: Ribosomal L28 family; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | Sps_03333 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme. (454 aa) |
