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| | purH | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (529 aa) |
| | atpB | F0F1-type ATP synthase, alpha subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (264 aa) |
| | atpE | ATP synthase, F0 subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (83 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | ATP synthase, F1 delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpA | Proton translocating ATP synthase, F1 alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (458 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | Sps_05571 | Type III secretion apparatus H+-transporting two-sector ATPase; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: type III secretion apparatus H+-transporting two-sector ATPase; ATPase, FliI/YscN family'. (448 aa) |
| | Sps_05508 | PFAM: Acetyltransferase (GNAT) domain. (151 aa) |
| | Sps_05443 | NUDIX family protein; PFAM: NUDIX domain. (181 aa) |
| | Sps_05426 | Competence/damage-inducible protein cinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; 'TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; amidohydrolase, PncC family; molybdenum cofactor synthesis domain'. (424 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | Sps_05383 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); 'PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain'; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (305 aa) |
| | Sps_05379 | Pyruvate dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa) |
| | Sps_05378 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa) |
| | Sps_05336 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (198 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | Sps_05106 | Protein containing C-terminal region of TrgB protein; PFAM: NUDIX domain; 'TIGRFAM: nudix-type nucleoside diphosphatase, YffH/AdpP family'. (203 aa) |
| | nnrE | yjeF-like protein, hydroxyethylthiazole kinase-related; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydrata [...] (499 aa) |
| | Sps_05001 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. (205 aa) |
| | Sps_04995 | PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | Sps_04790 | Fructose-2,6-bisphosphatase; PFAM: Histidine phosphatase superfamily (branch 1). (170 aa) |
| | Sps_04735 | Hypothetical protein; 'PFAM: Uncharacterized ACR, YhhQ family COG1738'; TIGRFAM: conserved hypothetical integral membrane protein. (278 aa) |
| | Sps_04622 | 'PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (747 aa) |
| | Sps_04548 | PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain. (622 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | Sps_04493 | PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. (264 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (424 aa) |
| | add | PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (331 aa) |
| | Sps_04409 | Hypothetical protein; PFAM: Region found in RelA / SpoT proteins. (267 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (211 aa) |
| | Sps_04365 | Putative Mg2+ and Co2+ transporter CorC; PFAM: CBS domain; Transporter associated domain. (291 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | carA | 'PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I'; 'TIGRFAM: carbamoyl-phosphate synthase, small subunit'; Belongs to the CarA family. (381 aa) |
| | carB | 'PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain'; 'TIGRFAM: carbamoyl-phosphate synthase, large subunit'; Belongs to the CarB family. (1072 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (257 aa) |
| | deoA | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (443 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (405 aa) |
| | deoD-2 | PFAM: Phosphorylase superfamily; 'TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD)'. (236 aa) |
| | Sps_04225 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. (187 aa) |
| | Sps_04212 | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (330 aa) |
| | deoD | PFAM: Phosphorylase superfamily; 'TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD)'. (234 aa) |
| | Sps_04110 | (p)ppGpp synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (734 aa) |
| | Sps_04109 | MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein. (265 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (430 aa) |
| | surE | 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | Sps_03950 | Cytosine deaminase-like metal-dependent hydrolase; PFAM: Amidohydrolase family. (454 aa) |
| | Sps_03948 | PFAM: OHCU decarboxylase; TIGRFAM: OHCU decarboxylase. (171 aa) |
| | Sps_03905 | Hypothetical protein. (155 aa) |
| | Sps_03892 | Hypothetical protein. (163 aa) |
| | pyrB | 'PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain'; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | Sps_03854 | PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. (273 aa) |
| | Sps_03841 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; 'PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase'; Belongs to the 5'-nucleotidase family. (582 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1293 aa) |
| | Sps_03780 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (446 aa) |
| | Sps_03742 | UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; PFAM: UDP-N-acetylglucosamine 2-epimerase; 'TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing'. (386 aa) |
| | Sps_03733 | dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; 'TIGRFAM: dTDP-glucose 4,6-dehydratase'; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (359 aa) |
| | Sps_03723 | CDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; 'TIGRFAM: CDP-glucose 4,6-dehydratase'. (366 aa) |
| | Sps_03722 | dTDP-4-dehydrorhamnose 3,5-epimerase-like enzyme. (143 aa) |
| | Sps_03718 | PFAM: NAD dependent epimerase/dehydratase family. (317 aa) |
| | Sps_03667 | UDP-glucose pyrophosphorylase; PFAM: Nucleotidyl transferase; TIGRFAM: UTP--glucose-1-phosphate uridylyltransferase. (307 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (345 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (374 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | Sps_03568 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | Sps_03531 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (155 aa) |
| | Sps_03506 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. (179 aa) |
| | Sps_03427 | Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase. (946 aa) |
| | Sps_03424 | Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family; PFAM: XdhC Rossmann domain; XdhC and CoxI family. (329 aa) |
| | Sps_03333 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme. (454 aa) |
| | Sps_03318 | (p)ppGpp synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | Sps_03302 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | Sps_03256 | Mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; mannose-6-phosphate isomerase, type 2. (479 aa) |
| | Sps_03248 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. (313 aa) |
| | Sps_03241 | PFAM: Nitrous oxide-stimulated promoter. (131 aa) |
| | purD | Phosphoribosylamine--glycine ligase; 'PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain'; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa) |
| | Sps_03155 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (152 aa) |
| | Sps_03146 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (252 aa) |
| | Sps_03088 | 'PFAM: Adenylate cyclase, class-I; Adenylate cyclase NT domain'; Belongs to the adenylyl cyclase class-1 family. (807 aa) |
| | Sps_03033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Sps_02993 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (306 aa) |
| | Sps_02987 | Hypothetical protein. (134 aa) |
| | Sps_02721 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (149 aa) |
| | Sps_02665 | Putative HD superfamily hydrolase; PFAM: HD domain. (199 aa) |
| | Sps_02654 | Hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (194 aa) |
| | pgk | PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | Sps_02638 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | Sps_02612 | Putative phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (188 aa) |
| | Sps_02485 | Flagellar biosynthesis/type III secretory pathway ATPase; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (420 aa) |
| | Sps_02469 | Hypothetical protein; PFAM: Isochorismatase family. (88 aa) |
| | Sps_02468 | Hypothetical protein; PFAM: Isochorismatase family. (93 aa) |
| | mtnN | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (283 aa) |
| | Sps_02442 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (537 aa) |
| | pgi | PFAM: Phosphoglucose isomerase; Belongs to the GPI family. (545 aa) |
| | Sps_02387 | PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (311 aa) |
| | Sps_02344 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa) |
| | Sps_02335 | Putative transcriptional regulator; 'PFAM: Uncharacterized ACR, COG1678'; Belongs to the UPF0301 (AlgH) family. (186 aa) |
| | Sps_02322 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (122 aa) |
| | Sps_02292 | Hypothetical protein; PFAM: ASCH domain; Belongs to the UPF0267 family. (105 aa) |
| | nadK | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | Sps_02209 | PFAM: Acetyltransferase (GNAT) domain. (164 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (285 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa) |
| | tdk | PFAM: Thymidine kinase. (192 aa) |
| | Sps_02077 | propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa) |
| | Sps_02059 | PFAM: Acyl-CoA thioesterase; TIGRFAM: acyl-CoA thioesterase II. (288 aa) |
| | Sps_02001 | PFAM: Inosine-uridine preferring nucleoside hydrolase; Belongs to the IUNH family. (313 aa) |
| | Sps_01955 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (127 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | Sps_01827 | Putative metal-dependent hydrolase; PFAM: Protein of unknown function DUF45. (169 aa) |
| | Sps_01817 | Ribonucleoside-triphosphate reductase class III activase subunit; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (157 aa) |
| | Sps_01781 | Hypothetical protein; PFAM: ATP-NAD kinase. (374 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | Sps_01746 | PFAM: Glyoxalase-like domain; TIGRFAM: lactoylglutathione lyase family protein. (194 aa) |
| | Sps_01715 | Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family; PFAM: XdhC Rossmann domain; XdhC and CoxI family. (339 aa) |
| | Sps_01714 | Putative MobA-like protein; PFAM: MobA-like NTP transferase domain. (218 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | Sps_01627 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa) |
| | Sps_01486 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; 'PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase'; 'TIGRFAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase'; Belongs to the 5'-nucleotidase family. (648 aa) |
| | Sps_01412 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; 'PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase'; Belongs to the 5'-nucleotidase family. (578 aa) |
| | Sps_01411 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; 'PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase'; Belongs to the 5'-nucleotidase family. (576 aa) |
| | udk | PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase. (211 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | Sps_01369 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (196 aa) |
| | Sps_01359 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (159 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (296 aa) |
| | purC | PFAM: SAICAR synthetase; 'TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type'. (368 aa) |
| | Sps_01264 | Cytosine deaminase-like metal-dependent hydrolase; PFAM: Amidohydrolase family. (431 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa) |
| | queE | Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa) |
| | Sps_01124 | 'PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain'; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa) |
| | Sps_01110 | Molybdenum cofactor sulfurylase; PFAM: XdhC Rossmann domain; XdhC and CoxI family; TIGRFAM: xanthine dehydrogenase accessory protein XdhC. (307 aa) |
| | alc | PFAM: Allantoicase repeat; TIGRFAM: allantoicase; Belongs to the allantoicase family. (352 aa) |
| | Sps_01108 | PFAM: OHCU decarboxylase; TIGRFAM: OHCU decarboxylase. (166 aa) |
| | Sps_01107 | Hydroxyisourate hydrolase; PFAM: HIUase/Transthyretin family; TIGRFAM: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (113 aa) |
| | Sps_01106 | PFAM: Ureidoglycolate hydrolase. (172 aa) |
| | Sps_01105 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (428 aa) |
| | Sps_00985 | ATPase FliI/YscN family; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (442 aa) |
| | Sps_00875 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. (223 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | cmk | PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (230 aa) |
| | Sps_00808 | Ribonucleoside-diphosphate reductase class Ia beta subunit; 'PFAM: Ribonucleotide reductase, small chain'. (376 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (355 aa) |
| | Sps_00791 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme. (536 aa) |
| | Sps_00776 | Putative HD superfamily hydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (195 aa) |
| | Sps_00775 | Hypothetical protein; PFAM: HD domain; 'TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative'. (197 aa) |
| | Sps_00774 | Hypothetical protein; PFAM: Phosphohydrolase-associated domain; 'TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative'. (204 aa) |
| | Sps_00757 | NTP pyrophosphohydrolase; PFAM: NUDIX domain. (196 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa) |
| | Sps_00558 | PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | Sps_00528 | acyl-CoA hydrolase; PFAM: Thioesterase superfamily. (142 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; 'PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain'; TIGRFAM: phosphoribosylaminoimidazole synthetase. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa) |
| | Sps_00477 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (116 aa) |
| | Sps_00474 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (128 aa) |
| | Sps_00447 | PFAM: 6-pyruvoyl tetrahydropterin synthase. (293 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa) |
| | coaA | PFAM: Phosphoribulokinase / Uridine kinase family; 'TIGRFAM: pantothenate kinase, bacterial type'. (316 aa) |
| | Sps_00274 | Lactoylglutathione lyase family protein; PFAM: Glyoxalase-like domain. (275 aa) |
| | Sps_00216 | PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain). (255 aa) |
| | Sps_00174 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (213 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | hldE | D-heptose-7- phosphate 1-kinase,D-heptose-1-phosphate adenylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa) |
| | hldD | ADP-glyceromanno-heptose 6-epimerase precursor; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (317 aa) |
| | Sps_00149 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | Sps_00148 | dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; 'TIGRFAM: dTDP-glucose 4,6-dehydratase'; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (356 aa) |
| | Sps_00147 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (288 aa) |
| | Sps_00113 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (444 aa) |
| | Sps_00027 | Putative acid phosphatase; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE. (348 aa) |
