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| | lpxL | Lipid A biosynthesis lauroyl/palmitoleoyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (307 aa) |
| | Sps_02993 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (306 aa) |
| | Sps_03033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Sps_03088 | 'PFAM: Adenylate cyclase, class-I; Adenylate cyclase NT domain'; Belongs to the adenylyl cyclase class-1 family. (807 aa) |
| | Sps_03146 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (252 aa) |
| | Sps_03155 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (152 aa) |
| | purH | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (529 aa) |
| | purD | Phosphoribosylamine--glycine ligase; 'PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain'; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa) |
| | Sps_03241 | PFAM: Nitrous oxide-stimulated promoter. (131 aa) |
| | Sps_03256 | Mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; mannose-6-phosphate isomerase, type 2. (479 aa) |
| | lpxC | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (306 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (489 aa) |
| | murG | UDP-N-acetylglucosamine-N- acetylmuramylpentapeptide N-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (365 aa) |
| | ftsW | Cell division-specific peptidoglycan biosynthesis regulator FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (405 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (449 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (492 aa) |
| | ftsI | Peptidoglycan synthetase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (580 aa) |
| | Sps_03302 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | Sps_03318 | (p)ppGpp synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa) |
| | Sps_03333 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme. (454 aa) |
| | Sps_03335 | Putative acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase; Glycosyl transferase family 2. (571 aa) |
| | Sps_03427 | Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase. (946 aa) |
| | Sps_03520 | Hypothetical protein; PFAM: NADH(P)-binding. (158 aa) |
| | Sps_03521 | Hypothetical protein; PFAM: NADH(P)-binding. (67 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (192 aa) |
| | Sps_03531 | Putative acyltransferase; PFAM: Acetyltransferase (GNAT) domain. (155 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | Sps_03568 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (374 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (345 aa) |
| | Sps_03614 | PFAM: Acyltransferase family. (350 aa) |
| | Sps_03615 | Glycosyltransferase; PFAM: Glycosyl transferases group 1. (426 aa) |
| | Sps_03619 | Glycosyltransferase; PFAM: Glycosyl transferases group 1. (420 aa) |
| | Sps_03620 | PFAM: Glycosyltransferase Family 4; Glycosyl transferases group 1. (383 aa) |
| | Sps_03623 | Uncharacterized protein involved in exopolysaccharide biosynthesis; PFAM: Chain length determinant protein. (665 aa) |
| | Sps_03625 | Lipid A core-O-antigen ligase-like enyme; PFAM: O-antigen ligase like membrane protein. (451 aa) |
| | Sps_03627 | Glycosyltransferase; PFAM: Glycosyl transferases group 1. (397 aa) |
| | Sps_03629 | Glycosyltransferase; PFAM: Glycosyl transferases group 1; Glycosyl transferase 4-like domain. (410 aa) |
| | Sps_03691 | Hypothetical protein. (527 aa) |
| | Sps_03692 | PFAM: Glycosyl transferase family 2. (347 aa) |
| | Sps_03695 | Glycosyl/glycerophosphate transferase, teichoic acid biosynthesis; PFAM: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. (455 aa) |
| | Sps_03704 | Putative nucleoside-diphosphate sugar epimerase; PFAM: CoA-binding domain; Polysaccharide biosynthesis protein. (645 aa) |
| | Sps_03713 | Putative PLP-dependent enzyme; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family. (395 aa) |
| | Sps_03717 | Glycosyltransferase; PFAM: Glycosyl transferases group 1. (383 aa) |
| | Sps_03718 | PFAM: NAD dependent epimerase/dehydratase family. (317 aa) |
| | Sps_03721 | PFAM: NAD dependent epimerase/dehydratase family. (309 aa) |
| | Sps_03722 | dTDP-4-dehydrorhamnose 3,5-epimerase-like enzyme. (143 aa) |
| | Sps_03723 | CDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; 'TIGRFAM: CDP-glucose 4,6-dehydratase'. (366 aa) |
| | Sps_03726 | Putative PLP-dependent enzyme; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family. (367 aa) |
| | Sps_03727 | Acetyltransferase (isoleucine patch superfamily); PFAM: Bacterial transferase hexapeptide (six repeats). (153 aa) |
| | Sps_03732 | Acyltransferase family protein; PFAM: Bacterial transferase hexapeptide (six repeats). (183 aa) |
| | Sps_03735 | CMP-N-acetylneuraminic acid synthetase; PFAM: Cytidylyltransferase. (229 aa) |
| | Sps_03744 | PFAM: Polysaccharide biosynthesis protein. (396 aa) |
| | Sps_03743 | PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; 'TIGRFAM: aminotransferase, LLPSF_NHT_00031 family'; Belongs to the DegT/DnrJ/EryC1 family. (383 aa) |
| | Sps_03745 | PFAM: Chain length determinant protein; G-rich domain on putative tyrosine kinase. (319 aa) |
| | Sps_03780 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (446 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1293 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa) |
| | pyrB | 'PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain'; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | Sps_04157 | Outer membrane protein V; PFAM: MltA-interacting protein MipA. (286 aa) |
| | Sps_04164 | Outer membrane protein V; PFAM: MltA-interacting protein MipA. (257 aa) |
| | Sps_04212 | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (330 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (405 aa) |
| | carB | 'PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain'; 'TIGRFAM: carbamoyl-phosphate synthase, large subunit'; Belongs to the CarB family. (1072 aa) |
| | carA | 'PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I'; 'TIGRFAM: carbamoyl-phosphate synthase, small subunit'; Belongs to the CarA family. (381 aa) |
| | kdsA | PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family. (282 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | Sps_04365 | Putative Mg2+ and Co2+ transporter CorC; PFAM: CBS domain; Transporter associated domain. (291 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (618 aa) |
| | mrdB | Cell elongation-specific peptidoglycan biosynthesis regulator RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (368 aa) |
| | Sps_04379 | Penicillin-binding protein 6; 'PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain'; Belongs to the peptidase S11 family. (390 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (424 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | Sps_04622 | 'PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain'. (747 aa) |
| | Sps_04625 | Outer membrane protein V; PFAM: MltA-interacting protein MipA. (293 aa) |
| | Sps_04735 | Hypothetical protein; 'PFAM: Uncharacterized ACR, YhhQ family COG1738'; TIGRFAM: conserved hypothetical integral membrane protein. (278 aa) |
| | Sps_04973 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (780 aa) |
| | Sps_04995 | PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (475 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | Sps_05204 | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (185 aa) |
| | Sps_05233 | Hypothetical protein; PFAM: Calcineurin-like phosphoesterase superfamily domain. (294 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | Sps_05397 | PFAM: LppC putative lipoprotein. (629 aa) |
| | gmhA-2 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (196 aa) |
| | Sps_05417 | Penicillin-binding protein, 1A family; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; 'TIGRFAM: penicillin-binding protein, 1A family'. (843 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (288 aa) |
| | Sps_05508 | PFAM: Acetyltransferase (GNAT) domain. (151 aa) |
| | Sps_05571 | Type III secretion apparatus H+-transporting two-sector ATPase; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: type III secretion apparatus H+-transporting two-sector ATPase; ATPase, FliI/YscN family'. (448 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (458 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | Proton translocating ATP synthase, F1 alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | ATP synthase, F1 delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | ATP synthase, F0 subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (83 aa) |
| | atpB | F0F1-type ATP synthase, alpha subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (264 aa) |
| | Sps_00097 | Hypothetical protein. (347 aa) |
| | Sps_00113 | Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (444 aa) |
| | Sps_00145 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (428 aa) |
| | kdkA | Lipopolysaccharide kinase (Kdo/WaaP) family; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (260 aa) |
| | Sps_00147 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (288 aa) |
| | Sps_00149 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | Sps_00150 | Glycosyl transferase; PFAM: N-terminal domain of galactosyltransferase; Glycosyl transferase family 2. (266 aa) |
| | Sps_00151 | PFAM: Glycosyltransferase family 9 (heptosyltransferase). (351 aa) |
| | Sps_00155 | PFAM: Glycosyltransferase family 25 (LPS biosynthesis protein). (249 aa) |
| | Sps_00157 | PFAM: Glycosyltransferase family 9 (heptosyltransferase). (371 aa) |
| | Sps_00158 | PFAM: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. (351 aa) |
| | hldD | ADP-glyceromanno-heptose 6-epimerase precursor; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (317 aa) |
| | hldE | D-heptose-7- phosphate 1-kinase,D-heptose-1-phosphate adenylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | Sps_00174 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (213 aa) |
| | murB | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (343 aa) |
| | coaA | PFAM: Phosphoribulokinase / Uridine kinase family; 'TIGRFAM: pantothenate kinase, bacterial type'. (316 aa) |
| | Sps_00447 | PFAM: 6-pyruvoyl tetrahydropterin synthase. (293 aa) |
| | Sps_00466 | Ykud domain-containing protein; 'PFAM: L,D-transpeptidase catalytic domain'. (179 aa) |
| | Sps_00473 | Flavodoxin reductase family protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain. (339 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; 'PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain'; TIGRFAM: phosphoribosylaminoimidazole synthetase. (345 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | Sps_00558 | PFAM: Lyase; Adenylosuccinate lyase C-terminal; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa) |
| | Sps_00616 | 'PFAM: Putative peptidoglycan binding domain; L,D-transpeptidase catalytic domain'. (466 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus. Belongs to the KdsB family. (245 aa) |
| | Sps_00648 | Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (356 aa) |
| | Sps_00649 | Putative PLP-dependent enzyme; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family. (394 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | Sps_00732 | PFAM: Glycosyl transferase family 2. (315 aa) |
| | Sps_00738 | 'PFAM: Putative peptidoglycan binding domain; L,D-transpeptidase catalytic domain'. (494 aa) |
| | Sps_00776 | Putative HD superfamily hydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (195 aa) |
| | Sps_00808 | Ribonucleoside-diphosphate reductase class Ia beta subunit; 'PFAM: Ribonucleotide reductase, small chain'. (376 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa) |
| | Sps_00966 | Cupin domain-containing protein; PFAM: Cupin domain. (148 aa) |
| | Sps_00985 | ATPase FliI/YscN family; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (442 aa) |
| | Sps_01115 | Putative membrane-associated, metal-dependent hydrolase; PFAM: Sulfatase; Domain of unknown function (DUF1705). (543 aa) |
| | queE | Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (222 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (336 aa) |
| | Sps_01296 | Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (389 aa) |
| | purC | PFAM: SAICAR synthetase; 'TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio type'. (368 aa) |
| | lpxM | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (311 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | mltG | Conserved hypothetical protein, YceG family; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (335 aa) |
| | udk | PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase. (211 aa) |
| | lpxK | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (340 aa) |
| | nagZ | Beta-glucosidase-like glycosyl hydrolase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (332 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | Sps_01817 | Ribonucleoside-triphosphate reductase class III activase subunit; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (157 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (244 aa) |
| | Sps_02077 | propionyl-CoA synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (654 aa) |
| | Sps_02078 | Hypothetical protein; PFAM: Putative peptidoglycan binding domain. (325 aa) |
| | Sps_02079 | Hypothetical protein; 'PFAM: L,D-transpeptidase catalytic domain'. (328 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (381 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (255 aa) |
| | fabZ | 3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (264 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (285 aa) |
| | Sps_02209 | PFAM: Acetyltransferase (GNAT) domain. (164 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | Sps_02314 | Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (382 aa) |
| | Sps_02335 | Putative transcriptional regulator; 'PFAM: Uncharacterized ACR, COG1678'; Belongs to the UPF0301 (AlgH) family. (186 aa) |
| | Sps_02387 | PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (311 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (510 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (283 aa) |
| | Sps_02485 | Flagellar biosynthesis/type III secretory pathway ATPase; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (420 aa) |
| | Sps_02543 | Hypothetical protein; 'PFAM: LysM domain; L,D-transpeptidase catalytic domain'. (300 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (266 aa) |
| | Sps_02572 | Putative membrane protein; PFAM: Domain of unknown function (DUF368). (306 aa) |
| | Sps_02609 | Uncharacterized lipoprotein; PFAM: Protein of unknown function (DUF3897); TIGRFAM: uncharacterized proteobacterial lipoprotein. (197 aa) |
| | Sps_02612 | Putative phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (188 aa) |
| | Sps_02665 | Putative HD superfamily hydrolase; PFAM: HD domain. (199 aa) |
| | Sps_02801 | Outer membrane protein V; PFAM: MltA-interacting protein MipA. (505 aa) |
