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| | Sps_00001 | PFAM: Flavodoxin. (146 aa) |
| | Sps_00050 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; WD40-like Beta Propeller Repeat; Amidohydrolase family. (1081 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | Sps_00462 | Acetyltransferase, GNAT family; PFAM: Acetyltransferase (GNAT) domain. (155 aa) |
| | Sps_00480 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (558 aa) |
| | Sps_00575 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme; 'TIGRFAM: cystathionine beta-lyase, bacterial'. (392 aa) |
| | Sps_00596 | PFAM: Bacterial NAD-glutamate dehydrogenase. (1612 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | Sps_00645 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (296 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (376 aa) |
| | dadA | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (417 aa) |
| | Sps_00691 | PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein. (375 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa) |
| | glyA-2 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa) |
| | Sps_00702 | PFAM: FAD dependent oxidoreductase; 'TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form'. (417 aa) |
| | Sps_00703 | 'PFAM: Sarcosine oxidase, delta subunit family'; 'TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form'. (104 aa) |
| | Sps_00705 | 'PFAM: Sarcosine oxidase, gamma subunit family'; 'TIGRFAM: sarcosine oxidase, gamma subunit family, heterotetrameric form'. (236 aa) |
| | Sps_00778 | PFAM: Aminotransferase class I and II. (404 aa) |
| | astE | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (344 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | Sps_00814 | PFAM: Aminotransferase class I and II. (401 aa) |
| | Sps_00843 | 'PFAM: homogentisate 1,2-dioxygenase'; 'TIGRFAM: homogentisate 1,2-dioxygenase'. (433 aa) |
| | Sps_00886 | Protein of unknown function (DUF227); PFAM: Ecdysteroid kinase. (347 aa) |
| | Sps_00911 | PFAM: Aminotransferase class I and II. (397 aa) |
| | Sps_00963 | Aspartate ammonia-lyase; PFAM: Fumarase C C-terminus; Lyase; TIGRFAM: aspartate ammonia-lyase. (480 aa) |
| | Sps_00966 | Cupin domain-containing protein; PFAM: Cupin domain. (148 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | Sps_01074 | 'PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain'; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa) |
| | Sps_01099 | PFAM: Ornithine cyclodeaminase/mu-crystallin family. (332 aa) |
| | Sps_01137 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (353 aa) |
| | Sps_01194 | PFAM: Glutamine amidotransferases class-II. (263 aa) |
| | Sps_01295 | GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (232 aa) |
| | Sps_01298 | 'PFAM: Glutamine synthetase, catalytic domain'. (459 aa) |
| | Sps_01310 | Hypothetical protein; PFAM: Serine dehydratase alpha chain; Belongs to the UPF0597 family. (424 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (231 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa) |
| | Sps_01394 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. (297 aa) |
| | Sps_01406 | Transcriptional regulator, GntR family; 'PFAM: Aminotransferase class I and II; Bacterial regulatory proteins, gntR family'. (456 aa) |
| | Sps_01409 | PFAM: Small subunit of acetolactate synthase; ACT domain; 'TIGRFAM: acetolactate synthase, small subunit'. (164 aa) |
| | Sps_01424 | 1-aminocyclopropane-1-carboxylate deaminase; PFAM: Pyridoxal-phosphate dependent enzyme. (313 aa) |
| | Sps_01497 | Tryptophanase; PFAM: Beta-eliminating lyase; 'TIGRFAM: tryptophanase, leader peptide-associated'. (465 aa) |
| | Sps_01572 | HIT family hydrolase, diadenosine tetraphosphate hydrolase; PFAM: HIT domain. (118 aa) |
| | Sps_01594 | 'PFAM: Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain'. (400 aa) |
| | Sps_01623 | PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (547 aa) |
| | Sps_01627 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa) |
| | Sps_01634 | Acetyltransferase, GNAT family; PFAM: Acetyltransferase (GNAT) domain. (158 aa) |
| | astB | Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (445 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpC family. (491 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | Sps_01864 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase. (392 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | Sps_02013 | Selenocysteine lyase; PFAM: Aminotransferase class-V. (395 aa) |
| | kynA | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (281 aa) |
| | Sps_02041 | PFAM: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; NAD binding domain of 6-phosphogluconate dehydrogenase; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (312 aa) |
| | Sps_02042 | PFAM: Enoyl-CoA hydratase/isomerase family; 2-enoyl-CoA Hydratase C-terminal region. (377 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (314 aa) |
| | Sps_02086 | hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like. (296 aa) |
| | Sps_02099 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase; Amidohydrolase family. (1027 aa) |
| | Sps_02100 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase. (454 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; PFAM: Hexapeptide repeat of succinyl-transferase; Bacterial transferase hexapeptide (six repeats); Tetrahydrodipicolinate N-succinyltransferase N-terminal; 'TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase'; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | Sps_02143 | PFAM: Flavodoxin. (154 aa) |
| | Sps_02151 | PFAM: Protein of unknown function (DUF2789). (75 aa) |
| | Sps_02235 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. (335 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | glsA | L-glutaminase; PFAM: Glutaminase; TIGRFAM: glutaminase A; Belongs to the glutaminase family. (304 aa) |
| | Sps_02405 | PFAM: Threonine synthase N terminus; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | Sps_02407 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa) |
| | Sps_02414 | Chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; DAHP synthetase I family; 'TIGRFAM: chorismate mutase domain of proteobacterial P-protein, clade 1'. (660 aa) |
| | Sps_02419 | Chorismate mutase; PFAM: Prephenate dehydrogenase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of T-protein. (379 aa) |
| | Sps_02457 | Glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1482 aa) |
| | mtnN | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | Sps_02560 | 'PFAM: Glutamine synthetase, catalytic domain'. (449 aa) |
| | Sps_02561 | Gamma-glutamyl-gamma-aminobutyrate hydrolase; PFAM: Peptidase C26. (253 aa) |
| | Sps_02658 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (404 aa) |
| | Sps_02690 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (156 aa) |
| | cysI | Sulfite reductase (NADPH) beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (577 aa) |
| | Sps_02800 | Sulfite reductase (NADPH) alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (600 aa) |
| | Sps_02853 | 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (409 aa) |
| | Sps_02941 | Putative dehydrogenase; PFAM: FAD dependent oxidoreductase. (375 aa) |
| | Sps_02949 | PFAM: Cysteine-rich CWC. (75 aa) |
| | Sps_02954 | PFAM: Methylenetetrahydrofolate reductase; 'TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form'; Belongs to the methylenetetrahydrofolate reductase family. (318 aa) |
| | Sps_02955 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (795 aa) |
| | Sps_02956 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: O-succinylhomoserine (thiol)-lyase. (386 aa) |
| | Sps_02957 | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. (124 aa) |
| | Sps_03048 | Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase; PFAM: Arginase family; Belongs to the arginase family. (347 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | ilvD | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | Sps_03126 | Acetolactate synthase, small subunit; PFAM: ACT domain. (75 aa) |
| | Sps_03128 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (521 aa) |
| | Sps_03132 | 'PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (six repeats)'; TIGRFAM: serine O-acetyltransferase. (261 aa) |
| | Sps_03207 | 5-phosphonooxy-L-lysine phospho-lyase apoenzyme; PFAM: Aminotransferase class-III; Phosphotransferase enzyme family;hydroxylysine kinase. (791 aa) |
| | Sps_03208 | 'PFAM: Alanine dehydrogenase/PNT, N-terminal domain'. (368 aa) |
| | Sps_03227 | PFAM: Aminotransferase class IV; 'TIGRFAM: branched-chain amino acid aminotransferase, group II'. (362 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | argA | N-acetylglutamate synthase; PFAM: Acetyltransferase (GNAT) family; Amino acid kinase family; TIGRFAM: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (439 aa) |
| | Sps_03313 | PFAM: Phosphotransferase enzyme family. (355 aa) |
| | Sps_03336 | Histidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: phenylalanine ammonia-lyase. (520 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | Sps_03358 | 'PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain'; 'TIGRFAM: glutamine synthetase, type I'. (469 aa) |
| | Sps_03403 | glycine/D-amino acid oxidase, deaminating; PFAM: FAD dependent oxidoreductase. (421 aa) |
| | cysZ | Uncharacterized protein involved in cysteine biosynthesis; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (266 aa) |
| | Sps_03543 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | Sps_03594 | Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (six repeats); TIGRFAM: serine O-acetyltransferase. (273 aa) |
| | Sps_03666 | Phenylalanine 4-hydroxylase; PFAM: Biopterin-dependent aromatic amino acid hydroxylase; 'TIGRFAM: phenylalanine-4-hydroxylase, monomeric form'. (265 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1293 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | Sps_03974 | D-cysteine desulfhydrase; PFAM: Pyridoxal-phosphate dependent enzyme; 'TIGRFAM: pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family'. (339 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | dsdA | D-serine ammonia-lyase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (442 aa) |
| | Sps_04230 | Phosphoserine phosphatase; PFAM: haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. (326 aa) |
| | carB | 'PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain'; 'TIGRFAM: carbamoyl-phosphate synthase, large subunit'; Belongs to the CarB family. (1072 aa) |
| | carA | 'PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I'; 'TIGRFAM: carbamoyl-phosphate synthase, small subunit'; Belongs to the CarA family. (381 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | Sps_04277 | PFAM: Acetyltransferase (GNAT) family. (142 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (424 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | Sps_04476 | Glutamate synthase family protein; PFAM: Iron-binding zinc finger CDGSH type; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (523 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa) |
| | Sps_04487 | Hypothetical protein; PFAM: Amidohydrolase family. (70 aa) |
| | Sps_04488 | Hypothetical protein; PFAM: Amidohydrolase. (114 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (539 aa) |
| | Sps_04796 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa) |
| | Sps_04805 | PFAM: Pyridoxal-phosphate dependent enzyme; 'TIGRFAM: 2,3-diaminopropionate biosynthesis protein SbnA'. (312 aa) |
| | Sps_04806 | 2,3-diaminopropionate biosynthesis protein SbnB; PFAM: Ornithine cyclodeaminase/mu-crystallin family; 'TIGRFAM: 2,3-diaminopropionate biosynthesis protein SbnB'. (337 aa) |
| | Sps_04844 | 5,10-methylenetetrahydrofolate reductase. (324 aa) |
| | gcvP-2 | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | Sps_04943 | PFAM: Amino acid kinase family; 'TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase'; Belongs to the aspartokinase family. (449 aa) |
| | Sps_05022 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1059 aa) |
| | astD | Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (486 aa) |
| | Sps_05067 | PFAM: Arginine N-succinyltransferase beta subunit; TIGRFAM: arginine N-succinyltransferase; arginine and ornithine succinyltransferase subunits. (339 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; PFAM: Aminotransferase class-III; 'TIGRFAM: succinylornithine transaminase family; transaminase, acetylornithine/succinylornithine family'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | Sps_05173 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (358 aa) |
| | Sps_05252 | GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (238 aa) |
| | argH | PFAM: Lyase; Argininosuccinate lyase C-terminal; TIGRFAM: argininosuccinate lyase. (455 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa) |
| | Sps_05420 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (261 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa) |
| | Sps_05423 | Acetylornithine deacetylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: acetylornithine deacetylase (ArgE). (383 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (346 aa) |
| | Sps_05517 | PFAM: Acetyltransferase (GNAT) family. (159 aa) |
| | hutH | Histidine ammonia-lyase; PFAM: Aromatic amino acid lyase; TIGRFAM: histidine ammonia-lyase. (510 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa) |
| | hutI | Imidazolonepropionase; PFAM: Amidohydrolase; TIGRFAM: imidazolonepropionase. (408 aa) |
| | Sps_05600 | 'PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain'; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (401 aa) |
| | mtnC | Acireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (225 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
