STRINGSTRING
Sps_04160 Sps_04160 Sps_04155 Sps_04155 Sps_04112 Sps_04112 Sps_04080 Sps_04080 Sps_03929 Sps_03929 Sps_03886 Sps_03886 Sps_03786 Sps_03786 Sps_03762 Sps_03762 Sps_03688 Sps_03688 Sps_03685 Sps_03685 Sps_03657 Sps_03657 Sps_03362 Sps_03362 Sps_03182 Sps_03182 Sps_02992 Sps_02992 Sps_02911 Sps_02911 Sps_02870 Sps_02870 Sps_00576 Sps_00576 Sps_00524 Sps_00524 Sps_00453 Sps_00453 Sps_00426 Sps_00426 Sps_00772 Sps_00772 Sps_00419 Sps_00419 gyrB gyrB Sps_00173 Sps_00173 Sps_00231 Sps_00231 Sps_00249 Sps_00249 Sps_05490 Sps_05490 Sps_05280 Sps_05280 Sps_05216 Sps_05216 parE parE Sps_05064 Sps_05064 Sps_05039 Sps_05039 Sps_04950 Sps_04950 Sps_04913 Sps_04913 Sps_04791 Sps_04791 Sps_04770 Sps_04770 Sps_04628 Sps_04628 Sps_04618 Sps_04618 Sps_04454 Sps_04454 Sps_04418 Sps_04418 Sps_00838 Sps_00838 Sps_00958 Sps_00958 Sps_01019 Sps_01019 Sps_01189 Sps_01189 Sps_01302 Sps_01302 Sps_01305 Sps_01305 Sps_01334 Sps_01334 Sps_01500 Sps_01500 Sps_01577 Sps_01577 htpG htpG Sps_01727 Sps_01727 Sps_02206 Sps_02206 Sps_02219 Sps_02219 Sps_02402 Sps_02402 Sps_02600 Sps_02600 Sps_02726 Sps_02726 Sps_00334 Sps_00334 Sps_04223 Sps_04223 Sps_04216 Sps_04216 Sps_04202 Sps_04202
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sps_04160'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (430 aa)
Sps_04155'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (483 aa)
Sps_04112Hpt sensor hybrid histidine kinase; 'PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Uncharacterized signal transduction histidine kinase domain (DUF2222); Hpt domain'. (937 aa)
Sps_04080'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (517 aa)
Sps_03929'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Hpt domain'. (988 aa)
Sps_03886PAS domain S-box; 'PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; Hpt domain; PAS fold'; TIGRFAM: PAS domain S-box. (1484 aa)
Sps_03786PAS/PAC sensor signal transduction histidine kinase; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain'. (373 aa)
Sps_03762Chemotaxis protein histidine kinase-like protein; 'PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain'. (723 aa)
Sps_03688Anti-sigma regulatory factor (Ser/Thr protein kinase); PFAM: Histidine kinase-like ATPase domain. (129 aa)
Sps_03685PAS domain S-box; 'PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; Hpt domain; PAS fold'; TIGRFAM: PAS domain S-box. (1178 aa)
Sps_03657Signal transduction histidine kinase regulating C4-dicarboxylate transport system; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (586 aa)
Sps_03362Signal transduction histidine kinase, nitrogen specific, NtrB; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold'. (347 aa)
Sps_03182'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (491 aa)
Sps_02992'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (416 aa)
Sps_02911'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (546 aa)
Sps_02870'PFAM: Four helix bundle sensory module for signal transduction; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (524 aa)
Sps_00576Proteobacterial dedicated sortase system histidine kinase; 'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'; TIGRFAM: proteobacterial dedicated sortase system histidine kinase. (798 aa)
Sps_00524'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold'. (1140 aa)
Sps_00453'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (627 aa)
Sps_00426'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (535 aa)
Sps_00772'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (572 aa)
Sps_00419'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (455 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
Sps_00173Histidine kinase,HAMP domain-containing protein,histidine kinase; 'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (705 aa)
Sps_00231'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (436 aa)
Sps_00249CheA signal transduction histidine kinase; 'PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain'. (701 aa)
Sps_05490'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (445 aa)
Sps_05280Multi-sensor hybrid histidine kinase; 'PFAM: Cache domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold'; TIGRFAM: PAS domain S-box. (1235 aa)
Sps_05216'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (429 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (628 aa)
Sps_05064'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (442 aa)
Sps_05039Histidine kinase; 'PFAM: Four helix bundle sensory module for signal transduction; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (503 aa)
Sps_04950Amino acid-binding domain sensor histidine kinase; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Bacterial extracellular solute-binding proteins, family 3'. (684 aa)
Sps_04913'PFAM: Ammonium Transporter Family; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'; TIGRFAM: ammonium transporter. (727 aa)
Sps_04791Na+/proline symporter; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Sodium:solute symporter family; His Kinase A (phospho-acceptor) domain'. (940 aa)
Sps_04770'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS domain'. (422 aa)
Sps_04628'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (427 aa)
Sps_04618'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold'; TIGRFAM: PAS domain S-box. (897 aa)
Sps_04454'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold'. (1191 aa)
Sps_04418Signal transduction histidine kinase regulating citrate/malate metabolism; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Sensor_kinase_SpoOB-type, alpha-helical domain; Sensory domain of two-component sensor kinase'. (539 aa)
Sps_00838'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (689 aa)
Sps_00958'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (561 aa)
Sps_01019'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Hpt domain'. (929 aa)
Sps_01189'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (479 aa)
Sps_01302'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain'. (432 aa)
Sps_01305'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phospho-acceptor) domain; PAS domain; CHASE3 domain; PAS fold'; TIGRFAM: PAS domain S-box. (1846 aa)
Sps_01334PAS domain S-box; 'PFAM: Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold'; TIGRFAM: PAS domain S-box. (883 aa)
Sps_01500'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (423 aa)
Sps_01577'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (446 aa)
htpGMolecular chaperone of HSP90 family; Molecular chaperone. Has ATPase activity. (638 aa)
Sps_01727'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Protein of unknown function (DUF3365)'. (559 aa)
Sps_02206'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase'. (444 aa)
Sps_02219PAS/PAC sensor signal transduction histidine kinase; 'PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Domain of unknown function (DUF3329)'; TIGRFAM: phosphate regulon sensor kinase PhoR. (448 aa)
Sps_02402PAS/PAC sensor hybrid histidine kinase; 'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain'; TIGRFAM: PAS domain S-box. (680 aa)
Sps_02600Signal transduction histidine kinase, nitrate/nitrite-specific, NarQ; 'PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Type IV pili methyl-accepting chemotaxis transducer N-term'. (567 aa)
Sps_02726'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Protein of unknown function (DUF3365)'. (555 aa)
Sps_00334'PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (459 aa)
Sps_04223'PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain'. (978 aa)
Sps_04216'PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; Hpt domain'; TIGRFAM: TMAO reductase sytem sensor TorS. (995 aa)
Sps_04202Putative periplasmic ligand-binding sensor domain; 'PFAM: Y_Y_Y domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold'. (1230 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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