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Sps_00438 Sps_00438 atpD atpD pstB-2 pstB-2 Sps_05613 Sps_05613 Sps_05610 Sps_05610 Sps_05571 Sps_05571 Sps_05494 Sps_05494 Sps_05454 Sps_05454 Sps_05394 Sps_05394 hslU hslU Sps_05354 Sps_05354 Sps_05352 Sps_05352 Sps_05314 Sps_05314 Sps_05281 Sps_05281 Sps_05207 Sps_05207 Sps_05201 Sps_05201 Sps_05174 Sps_05174 Sps_05053 Sps_05053 Sps_05025 Sps_05025 Sps_05024 Sps_05024 Sps_04994 Sps_04994 Sps_04951 Sps_04951 hmuV hmuV Sps_04895 Sps_04895 Sps_04867 Sps_04867 Sps_04789 Sps_04789 Sps_04774 Sps_04774 Sps_04771 Sps_04771 Sps_04685 Sps_04685 Sps_04679 Sps_04679 Sps_04667 Sps_04667 Sps_04633 Sps_04633 Sps_04578 Sps_04578 Sps_04569 Sps_04569 Sps_04509 Sps_04509 clpB clpB ftsH ftsH Sps_04134 Sps_04134 recA recA der der Sps_03787 Sps_03787 Sps_03785 Sps_03785 Sps_03780 Sps_03780 Sps_03684 Sps_03684 Sps_03664 Sps_03664 Sps_03658 Sps_03658 Sps_03638 Sps_03638 Sps_03577 Sps_03577 Sps_03481 Sps_03481 ntrC ntrC Sps_03223 Sps_03223 Sps_03098 Sps_03098 rho rho Sps_03060 Sps_03060 Sps_02967 Sps_02967 Sps_02863 Sps_02863 Sps_02810 Sps_02810 rbsA rbsA Sps_02679 Sps_02679 potA potA Sps_02540 Sps_02540 Sps_02485 Sps_02485 era era Sps_02339 Sps_02339 Sps_02166 Sps_02166 Sps_02034 Sps_02034 pstB pstB Sps_01942 Sps_01942 lon lon Sps_01875 Sps_01875 Sps_01870 Sps_01870 Sps_01772 Sps_01772 Sps_01771 Sps_01771 Sps_01671 Sps_01671 lolD lolD msbA msbA Sps_01556 Sps_01556 Sps_01468 Sps_01468 Sps_01349 Sps_01349 Sps_01262 Sps_01262 ruvB ruvB Sps_01070 Sps_01070 Sps_01045 Sps_01045 Sps_01044 Sps_01044 Sps_00985 Sps_00985 Sps_00874 Sps_00874 Sps_00742 Sps_00742 Sps_00601 Sps_00601 Sps_00566 Sps_00566 Sps_00427 Sps_00427 Sps_00422 Sps_00422 ccmA ccmA Sps_00325 Sps_00325 ftsE ftsE Sps_00286 Sps_00286 Sps_00172 Sps_00172 Sps_00169 Sps_00169 Sps_00118 Sps_00118 Sps_00113 Sps_00113 dnaA dnaA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sps_00438ATPase component of ABC transporters with duplicated ATPase domain; PFAM: ABC transporter. (529 aa)
atpDATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (458 aa)
pstB-2Phosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (249 aa)
Sps_05613ABC-type Na+ transport system, ATPase component; PFAM: ABC transporter. (244 aa)
Sps_05610ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter. (288 aa)
Sps_05571Type III secretion apparatus H+-transporting two-sector ATPase; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: type III secretion apparatus H+-transporting two-sector ATPase; ATPase, FliI/YscN family'. (448 aa)
Sps_05494ABC-type spermidine/putrescine transport system, ATPase component; PFAM: ABC transporter; Belongs to the ABC transporter superfamily. (369 aa)
Sps_05454Type II secretion system protein E (GspE); Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (527 aa)
Sps_05394PFAM: ABC transporter; TIGRFAM: glycine betaine/L-proline transport ATP binding subunit. (421 aa)
hslUATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (441 aa)
Sps_05354Type II secretory pathway, component ExeA (predicted ATPase); PFAM: AAA domain. (302 aa)
Sps_05352Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; 'PFAM: Type II secretion system (T2SS), protein E, N-terminal domain; Type II/IV secretion system protein'. (581 aa)
Sps_05314ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter. (318 aa)
Sps_05281PFAM: PhoH-like protein; PIN domain. (464 aa)
Sps_05207ABC-type (unclassified) transport system, ATPase component; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter. (243 aa)
Sps_05201ABC-type transport system involved in resistance to organic solvents, ATPase component; PFAM: ABC transporter. (272 aa)
Sps_05174Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)
Sps_05053ATPase component of ABC transporters with duplicated ATPase domain; PFAM: ABC transporter. (636 aa)
Sps_05025Cysteine export CydDC family ABC transporter permease subunit/ATP-binding protein CydD; PFAM: ABC transporter; ABC transporter transmembrane region; 'TIGRFAM: thiol reductant ABC exporter, CydD subunit'. (601 aa)
Sps_05024Cysteine export CydDC family ABC transporter permease subunit/ATP-binding protein CydC; PFAM: ABC transporter; ABC transporter transmembrane region; 'TIGRFAM: thiol reductant ABC exporter, CydC subunit'. (595 aa)
Sps_04994ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter. (341 aa)
Sps_04951Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (460 aa)
hmuVABC-type cobalamin/Fe3+-siderophore transport system, ATPase component; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (254 aa)
Sps_04895PFAM: ABC transporter; ABC transporter transmembrane region; 'TIGRFAM: ABC transporter, permease/ATP-binding protein'. (634 aa)
Sps_04867'PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; PAS domain'; TIGRFAM: PAS domain S-box. (492 aa)
Sps_04789ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component; PFAM: ABC transporter. (308 aa)
Sps_04774ABC-type antimicrobial peptide transport system, ATPase component; PFAM: ABC transporter. (258 aa)
Sps_04771Two component, sigma54 specific, transcriptional regulator, Fis family; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (503 aa)
Sps_04685'PFAM: CagE, TrbE, VirB family, component of type IV transporter system; AAA-like domain'; 'TIGRFAM: type IV secretion/conjugal transfer ATPase, VirB4 family'. (820 aa)
Sps_04679P-type conjugative transfer ATPase TrbB; PFAM: Type II/IV secretion system protein; TIGRFAM: P-type conjugative transfer ATPase TrbB. (308 aa)
Sps_04667Colicin V processing peptidase; PFAM: ABC transporter; ABC transporter transmembrane region; Peptidase C39 family. (718 aa)
Sps_04633PFAM: ATPase family associated with various cellular activities (AAA). (489 aa)
Sps_04578Fused permease/ATPase component of ABC transporter involved in Fe-S cluster assembly; PFAM: ABC transporter; ABC transporter transmembrane region. (589 aa)
Sps_04569ABC-type spermidine/putrescine transport system, ATPase component; PFAM: ABC transporter; TOBE domain. (342 aa)
Sps_04509PFAM: ATPase family associated with various cellular activities (AAA). (467 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
ftsHMembrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (657 aa)
Sps_04134PFAM: ABC transporter; 'TIGRFAM: ATP-binding cassette protein, ChvD family'. (554 aa)
recAProtein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (352 aa)
derRibosome-associated GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (490 aa)
Sps_03787Sigma54 specific transcriptional regulator, Fis family; 'PFAM: Flagellar regulatory protein FleQ; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (477 aa)
Sps_03785Two component, sigma54 specific, transcriptional regulator, Fis family; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (453 aa)
Sps_03780Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (446 aa)
Sps_03684Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (500 aa)
Sps_03664Transcriptional regulator, TyrR; PFAM: ACT domain; Sigma-54 interaction domain. (534 aa)
Sps_03658Two component, sigma54 specific, transcriptional regulator, Fis family; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (459 aa)
Sps_03638ABC-type multidrug transport system, ATPase and permease component; PFAM: ABC transporter; ABC transporter transmembrane region. (609 aa)
Sps_03577Putative ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; PFAM: ABC transporter. (250 aa)
Sps_03481PFAM: AAA domain. (242 aa)
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
Sps_03223Mg chelatase-related protein; 'PFAM: Magnesium chelatase, subunit ChlI; Subunit ChlI of Mg-chelatase'; TIGRFAM: Mg chelatase-related protein. (507 aa)
Sps_03098Type I secretion system ATPase, LssB family; PFAM: ABC transporter; ABC transporter transmembrane region; Peptidase C39 family; 'TIGRFAM: type I secretion system ATPase, LssB family'. (724 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (422 aa)
Sps_03060Type I secretion system ATPase, LssB family; PFAM: ABC transporter; ABC transporter transmembrane region; 'TIGRFAM: type I secretion system ATPase, LssB family'. (710 aa)
Sps_02967Flp pilus assembly protein, ATPase CpaF; PFAM: Type II/IV secretion system protein. (424 aa)
Sps_02863ABC-type antimicrobial peptide transport system, ATPase component; PFAM: ABC transporter. (222 aa)
Sps_02810PFAM: AFG1-like ATPase. (379 aa)
rbsARibose ABC transporter ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (494 aa)
Sps_02679Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; PFAM: GAF domain; Sigma-54 interaction domain. (570 aa)
potASpermidine/putrescine ABC transporter ATP-binding subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (378 aa)
Sps_02540Type II secretion system protein A; PFAM: Putative peptidoglycan binding domain; AAA domain. (544 aa)
Sps_02485Flagellar biosynthesis/type III secretory pathway ATPase; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (420 aa)
eraGTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (335 aa)
Sps_02339Pilus retraction ATPase PilT; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT. (345 aa)
Sps_02166ABC-type antimicrobial peptide transport system, ATPase component; PFAM: ABC transporter. (243 aa)
Sps_02034ATPase component of ABC transporters with duplicated ATPase domain; PFAM: ABC transporter. (530 aa)
pstBPhosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (272 aa)
Sps_01942ATPase component of Mn/Zn ABC-type transporter; PFAM: ABC transporter. (287 aa)
lonATP-dependent proteinase; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (785 aa)
Sps_01875ABC-type antimicrobial peptide transport system, ATPase component; 'PFAM: ABC transporter; Oligopeptide/dipeptide transporter, C-terminal region'. (275 aa)
Sps_01870Psp operon transcriptional activator PspF; 'PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'; TIGRFAM: psp operon transcriptional activator PspF. (356 aa)
Sps_01772ABC-type multidrug transport system, ATPase and permease component; PFAM: ABC transporter; ABC transporter transmembrane region. (550 aa)
Sps_01771ABC-type multidrug transport system, ATPase and permease component; PFAM: ABC transporter; ABC transporter transmembrane region. (562 aa)
Sps_01671'PFAM: DNA polymerase III tau subunit V interacting with alpha; DNA polymerase III subunits gamma and tau domain III; DNA polymerase III, delta subunit'; 'TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau'. (940 aa)
lolDLipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (236 aa)
msbALipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (606 aa)
Sps_01556ABC-type antimicrobial peptide transport system, ATPase component; PFAM: ABC transporter. (228 aa)
Sps_01468PFAM: ATPase family associated with various cellular activities (AAA). (695 aa)
Sps_01349ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter. (299 aa)
Sps_01262ATP-dependent helicase HrpA; PFAM: Helicase conserved C-terminal domain; Helicase associated domain (HA2); Oligonucleotide/oligosaccharide-binding (OB)-fold; Domain of unknown function (DUF3418); DEAD/DEAH box helicase; TIGRFAM: RNA helicase HrpA. (1299 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (339 aa)
Sps_01070Recombination protein MgsA; PFAM: MgsA AAA+ ATPase C terminal; ATPase family associated with various cellular activities (AAA). (443 aa)
Sps_01045Type VI secretion ATPase, ClpV1 family; 'PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA)'; 'TIGRFAM: type VI secretion ATPase, ClpV1 family'; Belongs to the ClpA/ClpB family. (861 aa)
Sps_01044'PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (519 aa)
Sps_00985ATPase FliI/YscN family; 'PFAM: ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: ATPase, FliI/YscN family'. (442 aa)
Sps_00874ATPase component of ABC transporters with duplicated ATPase domain; PFAM: ABC transporter. (536 aa)
Sps_00742Hypothetical protein. (438 aa)
Sps_00601ATPase component of ABC transporters with duplicated ATPase domain; PFAM: ABC transporter. (639 aa)
Sps_00566ATP-dependent Clp protease ATP-binding subunit ClpA; 'PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA)'; TIGRFAM: ATP-dependent Clp protease ATP-binding subunit clpA; Belongs to the ClpA/ClpB family. (752 aa)
Sps_00427Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (450 aa)
Sps_00422ABC-type phosphate/phosphonate transport system, ATPase component; PFAM: ABC transporter. (229 aa)
ccmAHeme ABC exporter, ATP-binding protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (215 aa)
Sps_00325GAF modulated sigma54 specific transcriptional regulator, Fis family; 'PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (596 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (231 aa)
Sps_00286ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component; PFAM: ABC transporter. (255 aa)
Sps_00172Two component, sigma54 specific, transcriptional regulator, Fis family; 'PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (460 aa)
Sps_00169ABC-type cobalt transport system, ATPase component; PFAM: ABC transporter. (239 aa)
Sps_00118Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; 'PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain'. (433 aa)
Sps_00113Flagellar protein export ATPase FliI; 'PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain'; 'TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family'. (444 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (462 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
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