STRINGSTRING
Sps_00326 Sps_00326 acsA acsA Sps_00691 Sps_00691 glyA glyA gcvH gcvH gcvP gcvP glyA-2 glyA-2 purU purU Sps_00765 Sps_00765 glcB glcB Sps_01093 Sps_01093 Sps_01119 Sps_01119 Sps_01298 Sps_01298 Sps_01358 Sps_01358 Sps_01371 Sps_01371 Sps_01633 Sps_01633 Sps_01734 Sps_01734 Sps_01937 Sps_01937 Sps_02046 Sps_02046 purU-2 purU-2 Sps_02560 Sps_02560 mdh mdh Sps_02847 Sps_02847 Sps_03047 Sps_03047 Sps_03122 Sps_03122 Sps_03358 Sps_03358 Sps_03850 Sps_03850 Sps_03945 Sps_03945 glyA-3 glyA-3 Sps_04636 Sps_04636 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT gcvT Sps_05371 Sps_05371 Sps_05377 Sps_05377 Sps_05405 Sps_05405 Sps_05513 Sps_05513 Sps_05514 Sps_05514 Sps_05515 Sps_05515 Sps_05519 Sps_05519 Sps_05520 Sps_05520 Sps_05521 Sps_05521
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sps_00326PFAM: Catalase; Catalase-related immune-responsive; Belongs to the catalase family. (502 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
Sps_00691PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein. (375 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
glyA-2Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
Sps_00765PFAM: Isocitrate lyase family. (527 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa)
Sps_01093Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (360 aa)
Sps_01119PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (213 aa)
Sps_01298'PFAM: Glutamine synthetase, catalytic domain'. (459 aa)
Sps_01358PFAM: NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; NAD binding domain of 6-phosphogluconate dehydrogenase. (291 aa)
Sps_01371PFAM: Haloacid dehalogenase-like hydrolase; 'TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; HAD-superfamily hydrolase, subfamily IIIA'. (226 aa)
Sps_01633PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (430 aa)
Sps_01734Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (330 aa)
Sps_01937PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. (389 aa)
Sps_02046acetyl-CoA acetyltransferase; 'PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain'; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa)
Sps_02560'PFAM: Glutamine synthetase, catalytic domain'. (449 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
Sps_02847PFAM: Catalase; Catalase-related immune-responsive; Belongs to the catalase family. (488 aa)
Sps_03047PFAM: short chain dehydrogenase; TIGRFAM: acetoacetyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
Sps_03122Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (380 aa)
Sps_03358'PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain'; 'TIGRFAM: glutamine synthetase, type I'. (469 aa)
Sps_03850PFAM: Malate synthase; TIGRFAM: malate synthase A. (483 aa)
Sps_03945PFAM: Malate synthase; TIGRFAM: malate synthase A. (547 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Sps_04636Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (323 aa)
gcvP-2Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
Sps_05371Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa)
Sps_05377Dihydrolipoamide dehydrogenase; 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain'; TIGRFAM: dihydrolipoamide dehydrogenase. (476 aa)
Sps_05405Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (235 aa)
Sps_05513Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (328 aa)
Sps_05514Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (189 aa)
Sps_05515Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (951 aa)
Sps_05519Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (341 aa)
Sps_05520Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (196 aa)
Sps_05521Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (949 aa)
Your Current Organism:
Shewanella psychrophila
NCBI taxonomy Id: 225848
Other names: CGMCC 1.6159, JCM 13876, S. psychrophila, Shewanella psychrophila Xiao et al. 2007 emend. Thorell et al. 2019, Shewanella sp. WP2, strain WP2
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.