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| | fadA | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa) |
| | glpE | Rhodanese-related sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (102 aa) |
| | Sps_00324 | PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (506 aa) |
| | Sps_00478 | PFAM: 5-carboxymethyl-2-hydroxymuconate isomerase. (116 aa) |
| | Sps_00484 | PFAM: Shikimate kinase; 'TIGRFAM: carbohydrate kinase, thermoresistant glucokinase family'. (172 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | Sps_00534 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa) |
| | Sps_00563 | PFAM: Monomeric isocitrate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type'; Belongs to the monomeric-type IDH family. (741 aa) |
| | Sps_00596 | PFAM: Bacterial NAD-glutamate dehydrogenase. (1612 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (376 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | glyA-2 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa) |
| | Sps_00759 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) |
| | Sps_00765 | PFAM: Isocitrate lyase family. (527 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa) |
| | Sps_00769 | Alcohol dehydrogenase AdhE; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa) |
| | Sps_00786 | Phosphoglucomutase, alpha-D-glucose phosphate-specific; 'PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I'; 'TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific'. (554 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | Sps_00843 | 'PFAM: homogentisate 1,2-dioxygenase'; 'TIGRFAM: homogentisate 1,2-dioxygenase'. (433 aa) |
| | Sps_00903 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); 'PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain'; 'TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I'; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | Sps_00905 | 'PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain'; 'TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I'; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (478 aa) |
| | Sps_00965 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (299 aa) |
| | Sps_01091 | 'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (413 aa) |
| | Sps_01093 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (360 aa) |
| | Sps_01107 | Hydroxyisourate hydrolase; PFAM: HIUase/Transthyretin family; TIGRFAM: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (113 aa) |
| | Sps_01108 | PFAM: OHCU decarboxylase; TIGRFAM: OHCU decarboxylase. (166 aa) |
| | alc | PFAM: Allantoicase repeat; TIGRFAM: allantoicase; Belongs to the allantoicase family. (352 aa) |
| | Sps_01111 | 'PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain'; 'TIGRFAM: xanthine dehydrogenase, molybdopterin binding subunit'. (786 aa) |
| | Sps_01112 | Xanthine dehydrogenase, small subunit; PFAM: 2Fe-2S iron-sulfur cluster binding domain; FAD binding domain in molybdopterin dehydrogenase; CO dehydrogenase flavoprotein C-terminal domain; [2Fe-2S] binding domain; 'TIGRFAM: xanthine dehydrogenase, small subunit'. (485 aa) |
| | Sps_01119 | PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (213 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa) |
| | Sps_01124 | 'PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain'; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa) |
| | Sps_01137 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (353 aa) |
| | Sps_01259 | Periplasmic nitrate reductase subunit NapB; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (151 aa) |
| | napA | Periplasmic nitrate reductase subunit NapA apoprotein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (829 aa) |
| | Sps_01298 | 'PFAM: Glutamine synthetase, catalytic domain'. (459 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa) |
| | Sps_01394 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. (297 aa) |
| | Sps_01526 | Aldose 1-epimerase-like enzyme; PFAM: Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (282 aa) |
| | Sps_01534 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (234 aa) |
| | Sps_01591 | PFAM: Rieske-like [2Fe-2S] domain; 'TIGRFAM: nitrite reductase [NAD(P)H], small subunit'. (115 aa) |
| | Sps_01592 | Assimilatory nitrite reductase (NAD(P)H) large subunit precursor; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Nitrite and sulphite reductase 4Fe-4S domain; BFD-like [2Fe-2S] binding domain; Nitrite/Sulfite reductase ferredoxin-like half domain; 'TIGRFAM: nitrite reductase [NAD(P)H], large subunit'. (879 aa) |
| | Sps_01595 | uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. (288 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | Sps_01627 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (396 aa) |
| | Sps_01628 | 'PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain'; 'TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component'. (940 aa) |
| | Sps_01629 | Succinate dehydrogenase subunit B; PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (235 aa) |
| | Sps_01630 | Succinate dehydrogenase subunit A; PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; 'TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup'; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa) |
| | Sps_01631 | Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | Sps_01632 | PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; 'TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit'. (124 aa) |
| | Sps_01633 | PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (430 aa) |
| | Sps_01654 | PFAM: Acylphosphatase. (91 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | fadJ | Fatty oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (708 aa) |
| | fadI | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | fabV | Putative paraquat-inducible protein B; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (400 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | Sps_01933 | Flavodoxin reductase family protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Pyridoxamine 5'-phosphate oxidase; Oxidoreductase NAD-binding domain. (552 aa) |
| | Sps_01937 | PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. (389 aa) |
| | Sps_02009 | Putative hydrolase or acyltransferase of alpha/beta superfamily; PFAM: Alpha/beta hydrolase family. (329 aa) |
| | Sps_02046 | acetyl-CoA acetyltransferase; 'PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain'; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | Sps_02076 | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (517 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; PFAM: Hexapeptide repeat of succinyl-transferase; Bacterial transferase hexapeptide (six repeats); Tetrahydrodipicolinate N-succinyltransferase N-terminal; 'TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase'; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | Sps_02235 | PFAM: Isocitrate/isopropylmalate dehydrogenase; 'TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases'. (335 aa) |
| | Sps_02314 | Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (382 aa) |
| | Sps_02326 | L-threonine aldolase; PFAM: Beta-eliminating lyase. (336 aa) |
| | Sps_02395 | Phosphoketolase; PFAM: XFP N-terminal domain; D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; XFP C-terminal domain. (792 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa) |
| | pgi | PFAM: Phosphoglucose isomerase; Belongs to the GPI family. (545 aa) |
| | Sps_02405 | PFAM: Threonine synthase N terminus; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (426 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | Sps_02407 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa) |
| | Sps_02457 | Glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1482 aa) |
| | Sps_02458 | Glutamate synthase (NADPH) small subunit; 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster'; 'TIGRFAM: glutamate synthase small subunit family protein, proteobacterial'. (469 aa) |
| | hemL | PFAM: Aminotransferase class-III; 'TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase'. (428 aa) |
| | Sps_02560 | 'PFAM: Glutamine synthetase, catalytic domain'. (449 aa) |
| | nrfA | Respiratory nitrite reductase (cytochrome); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (466 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa) |
| | Sps_02638 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pgk | PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | Sps_02641 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | Sps_02664 | PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (456 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa) |
| | Sps_02789 | uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (292 aa) |
| | cysH | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (261 aa) |
| | cysI | Sulfite reductase (NADPH) beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (577 aa) |
| | Sps_02800 | Sulfite reductase (NADPH) alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (600 aa) |
| | Sps_02823 | PFAM: Aminotransferase class-III; 'TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | Sps_02824 | PFAM: Aldehyde dehydrogenase family; TIGRFAM: succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa) |
| | Sps_02853 | 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (409 aa) |
| | napA-2 | Periplasmic nitrate reductase subunit NapA apoprotein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (827 aa) |
| | Sps_02873 | Periplasmic nitrate reductase subunit NapB; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (141 aa) |
| | Sps_02924 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (344 aa) |
| | Sps_02954 | PFAM: Methylenetetrahydrofolate reductase; 'TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form'; Belongs to the methylenetetrahydrofolate reductase family. (318 aa) |
| | Sps_02955 | Aspartate kinase; 'PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family'; TIGRFAM: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (795 aa) |
| | Sps_02986 | PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (366 aa) |
| | Sps_03032 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa) |
| | Sps_03033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | Sps_03047 | PFAM: short chain dehydrogenase; TIGRFAM: acetoacetyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | Sps_03058 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (338 aa) |
| | Sps_03073 | Succinate dehydrogenase subunit B; PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa) |
| | Sps_03074 | Succinate dehydrogenase subunit A; PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; 'TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup'. (670 aa) |
| | Sps_03075 | PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (242 aa) |
| | Sps_03076 | PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (243 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | Sps_03090 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (216 aa) |
| | Sps_03091 | Putative enzyme of heme biosynthesis; PFAM: HemX. (380 aa) |
| | Sps_03122 | Alanine-glyoxylate aminotransferase apoenzyme; PFAM: Aminotransferase class-V. (380 aa) |
| | Sps_03132 | 'PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (six repeats)'; TIGRFAM: serine O-acetyltransferase. (261 aa) |
| | Sps_03186 | Putative amidohydrolase; PFAM: Carbon-nitrogen hydrolase. (311 aa) |
| | Sps_03358 | 'PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain'; 'TIGRFAM: glutamine synthetase, type I'. (469 aa) |
| | Sps_03543 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | Sps_03564 | Formate acetyltransferase 1; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1. (760 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | Sps_03568 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (715 aa) |
| | Sps_03594 | Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (six repeats); TIGRFAM: serine O-acetyltransferase. (273 aa) |
| | Sps_03603 | Siroheme synthase, N-terminal domain; PFAM: Sirohaem biosynthesis protein central; Putative NAD(P)-binding; Sirohaem synthase dimerisation region; 'TIGRFAM: siroheme synthase, N-terminal domain'. (303 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (469 aa) |
| | Sps_03662 | Maleylacetoacetate isomerase; 'PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain'; TIGRFAM: maleylacetoacetate isomerase. (218 aa) |
| | Sps_03663 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; PFAM: Fumarylacetoacetate (FAA) hydrolase family. (328 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (220 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (477 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2; PFAM: Phosphoadenosine phosphosulfate reductase family; 'TIGRFAM: sulfate adenylyltransferase, small subunit'. (301 aa) |
| | Sps_03850 | PFAM: Malate synthase; TIGRFAM: malate synthase A. (483 aa) |
| | Sps_03940 | PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (508 aa) |
| | Sps_03945 | PFAM: Malate synthase; TIGRFAM: malate synthase A. (547 aa) |
| | Sps_04040 | PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (377 aa) |
| | Sps_04082 | Sodium ion-translocating decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (430 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | phnW | 2-aminoethylphosphonate--pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (373 aa) |
| | phnX | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. (269 aa) |
| | Sps_04168 | Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit; PFAM: Cytochrome c552; Belongs to the cytochrome c-552 family. (462 aa) |
| | Sps_04209 | Hypothetical protein; 'PFAM: NapC/NirT cytochrome c family, N-terminal region'. (230 aa) |
| | Sps_04210 | trimethylamine-N-oxide reductase TorA; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; TIGRFAM: molybdopterin guanine dinucleotide-containing S/N-oxide reductases; trimethylamine-N-oxide reductase TorA; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (830 aa) |
| | torD | Tat proofreading chaperone TorD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (232 aa) |
| | Sps_04230 | Phosphoserine phosphatase; PFAM: haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB'. (326 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | Sps_04286 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (285 aa) |
| | Sps_04287 | PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (386 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | Sps_04476 | Glutamate synthase family protein; PFAM: Iron-binding zinc finger CDGSH type; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (523 aa) |
| | Sps_04558 | PFAM: Nitroreductase family. (218 aa) |
| | Sps_04565 | PFAM: Aminotransferase class-III; 'TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | Sps_04623 | 'PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain'. (391 aa) |
| | Sps_04636 | Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (323 aa) |
| | Sps_04758 | PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (350 aa) |
| | Sps_04811 | 2-haloalkanoic acid dehalogenase, type II; PFAM: Haloacid dehalogenase-like hydrolase; 'TIGRFAM: Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; 2-haloalkanoic acid dehalogenase, type II'. (257 aa) |
| | Sps_04932 | Dienelactone hydrolase-like enzyme; PFAM: Dienelactone hydrolase family. (245 aa) |
| | Sps_04933 | Lactate dehydrogenase-like oxidoreductase; 'PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain'. (329 aa) |
| | Sps_04943 | PFAM: Amino acid kinase family; 'TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase'; Belongs to the aspartokinase family. (449 aa) |
| | fbp | D-fructose 1,6-bisphosphatase; PFAM: Fructose-1-6-bisphosphatase; Belongs to the FBPase class 1 family. (330 aa) |
| | Sps_04949 | PFAM: FAD binding domain; Cytochrome c3; TIGRFAM: flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (595 aa) |
| | ubiX | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (220 aa) |
| | Sps_05059 | PFAM: Phosphoribulokinase / Uridine kinase family. (295 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; PFAM: Aminotransferase class-III; 'TIGRFAM: succinylornithine transaminase family; transaminase, acetylornithine/succinylornithine family'; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa) |
| | nrfA-2 | Respiratory nitrite reductase (cytochrome); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (469 aa) |
| | fhs | PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (570 aa) |
| | Sps_05321 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); 'PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain'; 'TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I'; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | Sps_05361 | 'PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain'. (415 aa) |
| | Sps_05371 | Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | Sps_05377 | Dihydrolipoamide dehydrogenase; 'PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain'; TIGRFAM: dihydrolipoamide dehydrogenase. (476 aa) |
| | Sps_05378 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa) |
| | Sps_05379 | Pyruvate dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa) |
| | Sps_05406 | Ribulose-5-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | ppc | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (271 aa) |
| | pckA | ATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa) |
| | Sps_05513 | Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (328 aa) |
| | Sps_05514 | Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (189 aa) |
| | Sps_05515 | Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (951 aa) |
| | Sps_05519 | Formate dehydrogenase gamma subunit; PFAM: Cytochrome b(N-terminal)/b6/petB; 'TIGRFAM: formate dehydrogenase, gamma subunit'. (341 aa) |
| | Sps_05520 | Formate dehydrogenase beta subunit; PFAM: 4Fe-4S dicluster domain. (196 aa) |
| | Sps_05521 | Formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (949 aa) |
| | Sps_05595 | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family. (256 aa) |
| | Sps_05600 | 'PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain'; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (401 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
