STRINGSTRING
garR garR pta pta ackA ackA HP15_1516 HP15_1516 HP15_1517 HP15_1517 HP15_1518 HP15_1518 sdhA sdhA HP15_1520 HP15_1520 HP15_1521 HP15_1521 HP15_1522 HP15_1522 lpdG lpdG sucC sucC sucD sucD acyP acyP HP15_1631 HP15_1631 HP15_1632 HP15_1632 HP15_1633 HP15_1633 HP15_1634 HP15_1634 HP15_1636 HP15_1636 HP15_1657 HP15_1657 HP15_1797 HP15_1797 prpD prpD HP15_1929 HP15_1929 acnA acnA HP15_1931 HP15_1931 prpB2 prpB2 HP15_2020 HP15_2020 HP15_2053 HP15_2053 HP15_2203 HP15_2203 HP15_2655 HP15_2655 HP15_3045 HP15_3045 HP15_3046 HP15_3046 HP15_3142 HP15_3142 HP15_3144 HP15_3144 HP15_3255 HP15_3255 HP15_3404 HP15_3404 acnA-2 acnA-2 HP15_3800 HP15_3800 HP15_3945 HP15_3945 gcvH gcvH HP15_61 HP15_61 lipB lipB HP15_63 HP15_63 HP15_64 HP15_64 lipA-2 lipA-2 lpdG-2 lpdG-2 acsA acsA aldH6A1 aldH6A1 HP15_923 HP15_923
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
garR2-hydroxy-3-oxopropionate reductase. (290 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (709 aa)
ackAAcetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
HP15_1516Type II citrate synthase; Belongs to the citrate synthase family. (424 aa)
HP15_1517Succinate dehydrogenase, cytochrome b560 subunit. (125 aa)
HP15_1518Succinate dehydrogenase, hydrophobic membrane anchor; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase flavoprotein subunit-like protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
HP15_1520Succinate dehydrogenase/fumarate reductase iron-sulfur protein. (234 aa)
HP15_1521Alpha-ketoglutarate decarboxylase. (940 aa)
HP15_1522Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
lpdGDihydrolipoamide dehydrogenase. (480 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
acyPAcylphosphatase. (91 aa)
HP15_1631Dihydrolipoamide acetyltransferase. (378 aa)
HP15_1632Protein containing biotin/lipoyl attachment domain. (151 aa)
HP15_16332-oxoisovalerate dehydrogenase, E1 component, beta subunit. (325 aa)
HP15_1634Branched-chain alpha-keto acid dehydrogenase complex E1 alpha subunit; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (382 aa)
HP15_1636NADP-dependent isocitrate dehydrogenase-like protein. (572 aa)
HP15_1657Dihydrolipoamide dehydrogenase. (473 aa)
HP15_1797Quinone oxidoreductase, YhdH/YhfP family. (333 aa)
prpD2-methylcitrate dehydratase PrpD. (494 aa)
HP15_1929AcnD-accessory protein PrpF. (379 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (865 aa)
HP15_19312-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (376 aa)
prpB2Methylisocitrate lyase 2; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (295 aa)
HP15_2020Succinate-semialdehyde dehydrogenase I; Belongs to the aldehyde dehydrogenase family. (489 aa)
HP15_2053PrpE protein. (624 aa)
HP15_2203Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (864 aa)
HP15_2655Methylmalonate-semialdehyde dehydrogenase. (503 aa)
HP15_3045Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (554 aa)
HP15_3046Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
HP15_3142Quinone oxidoreductase, YhdH/YhfP family. (312 aa)
HP15_3144NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (533 aa)
HP15_3255Mercuric ion reductase. (480 aa)
HP15_3404Succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
acnA-2Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (919 aa)
HP15_3800Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (747 aa)
HP15_3945Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (471 aa)
gcvHGlycine cleavage H-protein, subgroup; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
HP15_61Chain A, alpha-keto acid dehydrogenase-like protein. (409 aa)
lipBLipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (212 aa)
HP15_632-oxoisovalerate dehydrogenase, E1 component, beta subunit. (268 aa)
HP15_64Catalytic domain of components of various dehydrogenase complexes. (432 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (350 aa)
lpdG-2Dihydrolipoamide dehydrogenase. (461 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
aldH6A1Methylmalonate-semialdehyde dehydrogenase. (497 aa)
HP15_923acetyl-coA synthetase/AMP-(fatty) acid ligase. (549 aa)
Your Current Organism:
Marinobacter adhaerens
NCBI taxonomy Id: 225937
Other names: M. adhaerens HP15, Marinobacter adhaerens HP15, Marinobacter adhaerens str. HP15, Marinobacter adhaerens strain HP15, marine bacterium HP15
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