STRINGSTRING
EF_0029 EF_0029 cysE cysE EF_0289 EF_0289 metC metC EF_0368 EF_0368 EF_0395 EF_0395 dapF dapF metK metK EF_1031 EF_1031 EF_1063 EF_1063 dapD dapD EF_1134 EF_1134 luxS luxS asd asd dapA dapA EF_1314 EF_1314 gdhA gdhA lysA lysA dapB dapB cysK cysK EF_1706 EF_1706 ilvE ilvE thrB thrB thrC thrC hom hom EF_2423 EF_2423 pfs pfs EF_2895 EF_2895 gshAB gshAB EF_3178 EF_3178 EF_3284 EF_3284
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EF_0029Aminotransferase, class II; Identified by match to TIGR protein family HMM TIGR01265. (404 aa)
cysESerine O-acetyltransferase; Identified by match to TIGR protein family HMM TIGR01853. (179 aa)
EF_0289Cysteine synthase B, putative; Similar to SP:P26945, GB:X57853, PID:580700, SP:P26945, GB:X57853, and PID:580700; identified by sequence similarity; putative. (305 aa)
metCCystathionine beta-lyase; Similar to GP:6513595; identified by sequence similarity; putative. (378 aa)
EF_0368Aspartate kinase; Similar to SP:P07105, GB:X05797, and PID:41406; identified by sequence similarity; putative; Belongs to the aspartokinase family. (450 aa)
EF_0395Methionine synthase, putative; Similar to GB:M17642, SP:P11469, PID:142968, and GB:AL009126; identified by sequence similarity; putative. (375 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (326 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (394 aa)
EF_1031Phosphorylase family protein; Similar to GP:10175861, and SP:O32028; identified by sequence similarity; putative. (218 aa)
EF_1063Conserved hypothetical protein; Similar to GP:10175831; identified by sequence similarity; putative. (159 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (233 aa)
EF_1134Peptidase, M20/M25/M40 family; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (389 aa)
luxSAutoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (152 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
EF_1314Aspartate aminotransferase, putative; Similar to GB:L05611, SP:Q04729, and PID:551706; identified by sequence similarity; putative. (405 aa)
gdhAGlutamate dehydrogenase; Similar to GP:10174720; identified by sequence similarity; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (259 aa)
cysKCysteine synthase A; Similar to SP:P37887; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
EF_1706Aminotransferase, class I; Similar to GP:6318592, and GP:6318592; identified by sequence similarity; putative. (392 aa)
ilvEBranched-chain amino acid aminotransferase; Identified by match to TIGR protein family HMM TIGR01121. (339 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (287 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa)
homHomoserine dehydrogenase; Similar to GB:X66975, GB:X60648, GB:X65371, GB:X62006, GB:X65372, SP:P26599, PID:32354, PID:35770, PID:35772, GB:X66975, GB:X60648, GB:X65371, GB:X62006, GB:X65372, SP:P26599, PID:32354, PID:35770, and PID:35772; identified by sequence similarity; putative. (430 aa)
EF_2423Transcriptional regulator, ArsR family; Identified by match to PFAM protein family HMM PF03551. (95 aa)
pfsMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
EF_2895Aminotransferase, class II; Similar to GB:M72150, GB:J02907, GB:M57888, SP:P20718, PID:181157, PID:181164, PID:183155, PID:338430, GB:M72150, GB:J02907, GB:M57888, SP:P20718, PID:181157, PID:181164, PID:183155, and PID:338430; identified by sequence similarity; putative. (388 aa)
gshABGlutamate--cysteine ligase, putative/amino acid ligase, putative; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. (756 aa)
EF_3178Peptidase, M20/M25/M40 family; Similar to GP:3980137; identified by sequence similarity; putative. (378 aa)
EF_3284Cystathionine gamma-synthase, putative; Similar to GB:U09072, SP:P01594, SP:P01602, SP:P01606, SP:P01609, SP:P01611, SP:P80362, PID:33319, PID:470556, PID:470562, PID:470576, PID:470592, PID:470594, PID:470596, PID:470598, PID:470600, PID:470602, PID:470604, PID:470606, PID:470608, PID:470610, PID:470612, PID:470618, PID:483882, PID:483884, PID:483886, PID:483892, PID:483908, PID:506423, PID:506425, PID:567134, PID:567136, PID:567138, PID:567148, PID:567154, PID:567158, PID:567168, PID:567172, PID:587326, PID:587328, PID:587330, PID:587332, PID:587334, PID:619602, PID:619603, PID:61961 [...] (395 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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