STRINGSTRING
EF_0372 EF_0372 EF_0373 EF_0373 kdpA kdpA kdpB kdpB kdpC kdpC kdpD kdpD EF_0571 EF_0571 EF_0697 EF_0697 kup kup EF_1038 EF_1038 EF_1050 EF_1050 EF_1051 EF_1051 EF_1186 EF_1186 EF_1187 EF_1187 EF_1188 EF_1188 EF_1189 EF_1189 EF_1190 EF_1190 EF_1191 EF_1191 EF_1192 EF_1192 vicR vicR vicK vicK EF_1195 EF_1195 EF_1196 EF_1196 EF_1197 EF_1197 EF_1198 EF_1198 EF_1199 EF_1199 EF_1260 EF_1260 EF_1261 EF_1261 EF_1701 EF_1701 EF_1702 EF_1702 phoP phoP EF_1704 EF_1704 EF_1705 EF_1705 EF_1744 EF_1744 EF_1745 EF_1745 lgt lgt hprK hprK EF_1751 EF_1751 EF_1752 EF_1752 EF_1753 EF_1753 EF_1754 EF_1754 pstB1 pstB1 pstB2 pstB2 EF_1757 EF_1757 EF_1758 EF_1758 EF_1759 EF_1759 EF_2558 EF_2558 EF_2695 EF_2695 EF_2696 EF_2696 EF_2697 EF_2697 EF_2698 EF_2698 EF_2699 EF_2699 EF_2700 EF_2700 EF_2701 EF_2701 EF_2908 EF_2908 EF_2909 EF_2909 EF_2910 EF_2910 EF_2911 EF_2911 EF_2912 EF_2912 EF_2913 EF_2913 greA greA mltG mltG EF_3289 EF_3289 EF_3290 EF_3290 EF_3329 EF_3329
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EF_0372DNA-binding response regulator; Similar to GP:10174197, GB:S59346, SP:P37198, and PID:432654; identified by sequence similarity; putative. (230 aa)
EF_0373Sensor histidine kinase; Similar to GB:U09281, GB:U09280, GB:U09279, PID:1468955, PID:1468956, PID:532764, PID:532768, and PID:624871; identified by sequence similarity; putative. (493 aa)
kdpAPotassium-transporting ATPase, subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (558 aa)
kdpBPotassium-transporting ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (676 aa)
kdpCPotassium-transporting ATPase, subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (176 aa)
kdpDSensor histidine kinase KdpD; Similar to GB:D13184, SP:Q08784, PID:602761, GB:D13184, SP:Q08784, and PID:602761; identified by sequence similarity; putative. (850 aa)
EF_0571DNA-binding response regulator; Similar to GB:D13184, SP:Q08784, PID:602761, SP:Q02940, and PID:151433; identified by sequence similarity; putative. (229 aa)
EF_0697Conserved hypothetical protein; Similar to GP:10173555; identified by sequence similarity; putative; Belongs to the UPF0374 family. (177 aa)
kupPotassium uptake protein; Transport of potassium into the cell; Belongs to the HAK/KUP transporter (TC 2.A.72) family. (668 aa)
EF_1038Lipoprotein, putative. (361 aa)
EF_1050DNA-binding response regulator; Similar to GP:6117972, and GP:9230552; identified by sequence similarity; putative. (228 aa)
EF_1051Sensor histidine kinase; Identified by match to PFAM protein family HMM PF03070. (502 aa)
EF_1186Identified by match to TIGR protein family HMM TIGR01390; Belongs to the 5'-nucleotidase family. (460 aa)
EF_1187Conserved hypothetical protein; Similar to GP:10176056; identified by sequence similarity; putative. (209 aa)
EF_1188Hydrolase, haloacid dehalogenase family; Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro; Belongs to the HAD-like hydrolase superfamily. NagD family. (256 aa)
EF_1189Conserved hypothetical protein; Identified by Glimmer2; putative. (217 aa)
EF_1190Conserved hypothetical protein; Identified by Glimmer2; putative. (189 aa)
EF_1191DegV family protein; Similar to GB:M13144, GB:M13981, GB:X04446, GB:X04445, SP:P05111, PID:1204105, PID:186413, PID:307068, and PID:490130; identified by sequence similarity; putative. (286 aa)
EF_1192Aquaporin Z; Similar to SP:P48838; identified by sequence similarity; putative; Belongs to the MIP/aquaporin (TC 1.A.8) family. (221 aa)
vicRDNA-binding response regulator VicR; Enterococcus facaelis VicR ORF may be annotated incorrectly in AJ012050. The DNA sequences are identical, thus AJ012050 also contains two in-frame stop codons upstream of start site used in ORF03244, and there is an RBS found near the start site for ORF03244; similar to GP:6687469, and GP:5114230; identified by sequence similarity; putative. (234 aa)
vicKSensory box histidine kinase VicK; Similar to GP:6687470; identified by sequence similarity; putative. (609 aa)
EF_1195Hypothetical protein; Identified by Glimmer2; putative. (436 aa)
EF_1196Conserved hypothetical protein; Similar to GP:6687473, GB:U09281, GB:U09280, GB:U09279, PID:1468955, PID:1468956, PID:532764, PID:532768, and PID:624871; identified by sequence similarity; putative. (284 aa)
EF_1197Metallo-beta-lactamase YycJ; Similar to GP:6687474, and GP:6687474; identified by sequence similarity; putative. (268 aa)
EF_1198Conserved hypothetical protein; Identified by match to PFAM protein family HMM PF02673. (304 aa)
EF_1199Conserved hypothetical protein; Similar to SP:P30197, GB:X62386, and PID:46970; identified by sequence similarity; putative. (288 aa)
EF_1260DNA-binding response regulator; Similar to GP:4104608, GB:S59346, SP:P37198, and PID:432654; identified by sequence similarity; putative. (239 aa)
EF_1261Sensor histidine kinase; Similar to GP:4104609; identified by sequence similarity; putative. (489 aa)
EF_1701Conserved hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. (112 aa)
EF_1702Conserved hypothetical protein; Similar to SP:P36681, GB:U00096, and PID:1786290; identified by sequence similarity; putative. (154 aa)
phoPAlkaline phosphatase synthesis transcriptional regulatory protein PhoP; Similar to GP:10175779, GB:M18391, GB:Z27409, SP:P21709, PID:339717, and PID:482917; identified by sequence similarity; putative. (236 aa)
EF_1704Sensory box histidine kinase; Similar to GP:10175778; identified by sequence similarity; putative. (591 aa)
EF_1705Identified by match to PFAM protein family HMM PF03466. (296 aa)
EF_1744General stress protein, putative; Similar to GP:6165966; identified by sequence similarity; putative. (195 aa)
EF_1745Conserved hypothetical protein; Similar to GP:4321110, and GP:12723517; identified by sequence similarity; putative. (143 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (278 aa)
hprKHPr(Ser) serine kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisa [...] (311 aa)
EF_1751Membrane protein, putative; Similar to GP:6688476; identified by sequence similarity; putative. (118 aa)
EF_1752Conserved hypothetical protein; Similar to GB:L31616, PID:520778, GB:AE000785, and GB:AE000788; identified by sequence similarity; putative. (107 aa)
EF_1753Conserved hypothetical protein; Similar to GP:6688474, and GP:6688474; identified by sequence similarity; putative. (533 aa)
EF_1754PhoU family protein; Plays a role in the regulation of phosphate uptake. (225 aa)
pstB1Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (252 aa)
pstB2Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (269 aa)
EF_1757Phosphate ABC transporter, permease protein; Similar to GB:M36860, GB:M16983, GB:M17265, GB:M17266, GB:M17267, GB:M17268, GB:M17271, GB:M17272, GB:M17273, GB:M17275, GB:M17276, GB:M17277, GB:M17278, GB:M17279, GB:M17281, GB:M17282, GB:M17270, GB:M17280, GB:M17274, GB:M24782, GB:X15603, GB:M26867, SP:P15502, PID:1432162, PID:182020, PID:182062, PID:182064, GB:M36860, GB:M16983, GB:M17265, GB:M17266, GB:M17267, GB:M17268, GB:M17271, GB:M17272, GB:M17273, GB:M17275, GB:M17276, GB:M17277, GB:M17278, GB:M17279, GB:M17281, GB:M17282, GB:M17270, GB:M17280, GB:M17274, GB:M24782, GB:X15603, GB: [...] (294 aa)
EF_1758Phosphate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (306 aa)
EF_1759Phosphate ABC transporter, phosphate-binding protein; Identified by match to TIGR protein family HMM TIGR00975. (284 aa)
EF_2558Cation transporter; Similar to SP:P43440, and SP:P26829; identified by sequence similarity; putative. (471 aa)
EF_2695Hypothetical protein; Identified by Glimmer2; putative. (98 aa)
EF_2696Identified by match to PFAM protein family HMM PF03118. (198 aa)
EF_2697Conserved domain protein; Similar to GB:M81757, SP:P39019, PID:337733, GB:M81757, SP:P39019, and PID:337733; identified by sequence similarity; putative. (226 aa)
EF_2698Tellurite resistance protein, putative; Similar to GB:U14003, SP:P39390, PID:537182, GB:U00096, and PID:1790798; identified by sequence similarity; putative; Belongs to the TelA family. (395 aa)
EF_2699Hypothetical protein; Identified by Glimmer2; putative. (31 aa)
EF_2700MutT/nudix family protein; Similar to GP:8163717; identified by sequence similarity; putative. (273 aa)
EF_2701Acetyltransferase, GNAT family; Identified by match to TIGR protein family HMM TIGR01575. (174 aa)
EF_2908Glycosyl transferase, group 2 family protein; Similar to SP:P19690, PID:216911, and PID:1575711; identified by sequence similarity; putative. (312 aa)
EF_2909Conserved hypothetical protein; Similar to SP:P35092, and SP:P35093; identified by sequence similarity; putative. (103 aa)
EF_2910Potassium uptake protein; Similar to GP:10175284, and GP:3288678; identified by sequence similarity; putative. (221 aa)
EF_2911DNA-binding response regulator, LuxR family; Similar to GP:5830527, and GP:9501772; identified by sequence similarity; putative. (210 aa)
EF_2912Sensor histidine kinase, putative; Similar to GB:L35044, and PID:516627; identified by sequence similarity; putative. (367 aa)
EF_2913Conserved hypothetical protein; Similar to GP:9501770, and GP:16413478; identified by sequence similarity; putative. (243 aa)
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (159 aa)
mltGConserved hypothetical protein TIGR00247; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (461 aa)
EF_3289DNA-binding response regulator; Similar to GP:4104605; identified by sequence similarity; putative. (229 aa)
EF_3290Sensor histidine kinase; Similar to GP:4104606; identified by sequence similarity; putative. (393 aa)
EF_3329DNA-binding response regulator; Similar to GP:10173434, GB:M64571, GB:U19727, SP:P27816, PID:187383, and PID:641916; identified by sequence similarity; putative. (240 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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