STRINGSTRING
EF_1300 EF_1300 EF_3294 EF_3294 EF_3157 EF_3157 mltG mltG EF_2891 EF_2891 EF_2890 EF_2890 EF_2822 EF_2822 EF_2794 EF_2794 EF_2626 EF_2626 upp upp EF_2457 EF_2457 xpt xpt gspA-2 gspA-2 gspA-1 gspA-1 purF purF comFC comFC lgt lgt EF_1740 EF_1740 pyrR pyrR pyrE pyrE apt apt EF_1518 EF_1518 EF_1173 EF_1173 EF_1148 EF_1148 murG murG EF_0957 EF_0957 tgt tgt queA queA EF_0680 EF_0680 EF_0335 EF_0335 hpt hpt deoD-2 deoD-2 deoD-1 deoD-1 pyn pyn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EF_1300Cell division protein, FtsW/RodA/SpovE family; Similar to GP:6138753, SP:P35791, and PID:142073; identified by sequence similarity; putative; Belongs to the SEDS family. (391 aa)
EF_3294Membrane protein, putative; Identified by match to TIGR protein family HMM TIGR01770. (560 aa)
EF_3157Glycosyl hydrolase, family 65; Similar to GB:L26976, GB:L27490, GB:L27490, GB:L27488, GB:L27489, GB:S69200, GB:S69326, GB:U13216, GB:U13214, GB:X83860, GB:X83859, GB:X83857, GB:X83861, GB:X83858, GB:X83862, GB:X83863, GB:U13217, GB:U13215, GB:U13218, GB:S68874, GB:L32660, GB:S68875, SP:P43115, PID:1199761, PID:483352, PID:532738, PID:532740, PID:532742, PID:532744, PID:532746, PID:633208, PID:633210, PID:633212, PID:633214, PID:633216, PID:633218, PID:633220, and SP:P09947; identified by sequence similarity; putative. (778 aa)
mltGConserved hypothetical protein TIGR00247; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (461 aa)
EF_2891Glycosyl transferase, group 1 family protein; Identified by match to PFAM protein family HMM PF00534. (334 aa)
EF_2890Glycosyl transferase, group 1 family protein; Similar to GP:2108334; identified by sequence similarity; putative. (407 aa)
EF_2822Portal protein; Identified by match to TIGR protein family HMM TIGR01537. (408 aa)
EF_2794Membrane protein, putative; Identified by match to TIGR protein family HMM TIGR01770. (516 aa)
EF_2626Nicotinate phosphoribosyltransferase, putative; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (494 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
EF_2457Cell division protein, FtsW/RodA/SpoVE family; Similar to GP:6138753, SP:P35791, and PID:142073; identified by sequence similarity; putative; Belongs to the SEDS family. (402 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis; Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily. (193 aa)
gspA-2General stress protein A; Similar to GB:D11327, SP:P35236, PID:187228, and PID:219902; identified by sequence similarity; putative. (281 aa)
gspA-1General stress protein A; Similar to GB:D11327, SP:P35236, PID:187228, PID:219902, GB:D11327, SP:P35236, PID:187228, and PID:219902; identified by sequence similarity; putative. (300 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (479 aa)
comFCCompetence protein F; Similar to GB:M35663, GB:M85294, SP:P19525, PID:1537049, PID:189506, and PID:189782; identified by sequence similarity; putative. (228 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (278 aa)
EF_1740Penicillin-binding protein 1B, putative; Similar to GP:2982642; identified by sequence similarity; putative. (803 aa)
pyrRPyrimidine operon regulatory protein PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, by binding to the anti-antiterminator region of the 5' leader on pyr mRNA. This probably favors formation of a transcription terminator hairpin, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
EF_1518Conserved hypothetical protein; Similar to GP:6470159; identified by sequence similarity; putative. (209 aa)
EF_1173Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (248 aa)
EF_1148Penicillin-binding protein 1A; Similar to GP:6563343; identified by sequence similarity; putative. (778 aa)
murGUDPdiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (363 aa)
EF_0957Glycosyl hydrolase, family 65; Similar to GB:L18927, SP:Q08885, and PID:349619; identified by sequence similarity; putative. (764 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (381 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (343 aa)
EF_0680Penicillin-binding protein 2A; Similar to GP:2982644; identified by sequence similarity; putative. (728 aa)
EF_0335Minor head protein; A probable mono(ADP-ribosyl)transferase, it may ADP- ribosylate Arg in target protein(s). Upon expression in yeast cells causes cell death. (487 aa)
hptHypoxanthine-guanine phosphoribosyltransferase; Similar to GB:K00558, GB:S62639, SP:P04687, SP:P05215, PID:340019, PID:340021, and PID:37492; identified by sequence similarity; putative. (181 aa)
deoD-2Purine nucleoside phosphorylase; Similar to SP:P37623, PID:466611, GB:U00096, and PID:1789886; identified by sequence similarity; putative. (235 aa)
deoD-1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
pynPyrimidine-nucleoside phosphorylase; Identified by match to PFAM protein family HMM PF02885. (433 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.