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purA purA guaA guaA tilS tilS EF_0625 EF_0625 lplA-1 lplA-1 murE murE gatC gatC gatA gatA gatB gatB EF_0737 EF_0737 ddl ddl murF murF murD murD EF_1033 EF_1033 pyrG pyrG pyraB pyraB pyraA pyraA fhs fhs purD purD purM purM purL purL purQ purQ purS purS purC purC purK-1 purK-1 panC panC murC murC glnA glnA vanB vanB purK-2 purK-2 EF_2415 EF_2415 EF_2585 EF_2585 EF_2586 EF_2586 nadE nadE EF_2626 EF_2626 lplA-2 lplA-2 EF_2791 EF_2791 tmcAL tmcAL accC accC EF_2928 EF_2928 EF_2983 EF_2983 gshAB gshAB birA birA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
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purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
tilSConserved domain protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (462 aa)
EF_0625Hypothetical protein; Identified by Glimmer2; putative. (228 aa)
lplA-1Lipoate-protein ligase A; Similar to SP:P26997, and PID:217186; identified by sequence similarity; putative. (337 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase, putative; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (508 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (101 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (489 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (476 aa)
EF_0737Amidase, putative; Similar to GB:L23970, SP:P40593, GB:M80522, PID:142316, and PID:398002; identified by sequence similarity; putative. (528 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (348 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (457 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (456 aa)
EF_10336-aminohexanoate-cyclic-dimer hydrolase, putative; Similar to SP:P13397, GB:U03161, SP:P42512, and PID:454353; identified by sequence similarity; putative; Belongs to the amidase family. (729 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa)
pyraBCarbamoyl-phosphate synthase, large subunit; Similar to GP:2598551, and SP:P25994; identified by sequence similarity; putative. (1060 aa)
pyraACarbamoyl-phosphate synthase, small subunit; Similar to GP:7688228, and SP:P25993; identified by sequence similarity; putative; Belongs to the CarA family. (359 aa)
fhsFormate--tetrahydrofolate ligase; Similar to GB:L33075, SP:P46940, PID:473931, PID:536844, GB:D29640, SP:P46940, PID:473931, and PID:536844; identified by sequence similarity; putative; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
purDPhosphoribosylamine--glycine ligase; Similar to SP:P12039; identified by sequence similarity; putative; Belongs to the GARS family. (415 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Similar to SP:P12043; identified by sequence similarity; putative. (343 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (739 aa)
purQPhosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (224 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (83 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to SP:P12046; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. (237 aa)
purK-1Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (374 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (445 aa)
glnAGlutamine synthetase, type I; Identified by match to PFAM protein family HMM PF03951. (446 aa)
vanBD-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding. (342 aa)
purK-2Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (371 aa)
EF_2415Conserved hypothetical protein; Similar to GP:10173971, and SP:P54464; identified by sequence similarity; putative. (149 aa)
EF_2585Mur ligase family protein; Similar to GP:3820539; identified by sequence similarity; putative. (450 aa)
EF_2586Cobyric acid synthase, putative; Similar to GP:3820538; identified by sequence similarity; putative. (230 aa)
nadENH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)
EF_2626Nicotinate phosphoribosyltransferase, putative; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (494 aa)
lplA-2Lipoate-protein ligase A; Similar to GP:10173297, and SP:P32099; identified by sequence similarity; putative. (334 aa)
EF_27915-formyltetrahydrofolate cyclo-ligase family protein; Similar to GP:10174034; identified by sequence similarity; putative; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (180 aa)
tmcALConserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (392 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
EF_2928FolC family protein; Similar to GB:X16468, GB:J00116, GB:X58709, GB:M27468, GB:X06268, GB:M63281, GB:X13783, GB:X16711, GB:X03320, GB:X02378, GB:X02376, GB:X02375, GB:X02372, GB:X02374, GB:X57010, GB:S76829, GB:U15195, GB:X02371, SP:P02458, PID:1335019, PID:1335020, PID:1335022, PID:1335023, PID:1335024, PID:180396, PID:180811, PID:29516, PID:30041, PID:30097, PID:394700, PID:529398, PID:557054, PID:562268, PID:575948, PID:673389, PID:825645, PID:930050, GB:X16468, GB:J00116, GB:X58709, GB:M27468, GB:X06268, GB:M63281, GB:X13783, GB:X16711, GB:X03320, GB:X02378, GB:X02376, GB:X02375, G [...] (440 aa)
EF_2983glutamyl-tRNA(Gln) amidotransferase, A subunit, putative; Similar to GB:U03161, SP:P42512, and PID:454353; identified by sequence similarity; putative; Belongs to the amidase family. (482 aa)
gshABGlutamate--cysteine ligase, putative/amino acid ligase, putative; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. (756 aa)
birABirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (330 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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