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nth nth recF recF ssb-1 ssb-1 radA radA ruvA ruvA ruvB ruvB EF_0109 EF_0109 mfd mfd EF_0259 EF_0259 EF_0275 EF_0275 ogt ogt tag-1 tag-1 EF_0325 EF_0325 sodA sodA ssb-2 ssb-2 ssb-3 ssb-3 EF_0655 EF_0655 EF_0659 EF_0659 EF_0682 EF_0682 ligA ligA uvrB uvrB uvrA uvrA EF_0780 EF_0780 polA polA fpg fpg ung ung EF_0971 EF_0971 recN recN drrC drrC EF_1080 EF_1080 rexB rexB rexA rexA EF_1130 EF_1130 recU recU EF_1165 EF_1165 trxB trxB mutS2 mutS2 uvrC uvrC EF_1435 EF_1435 lexA lexA EF_1587 EF_1587 EF_1595 EF_1595 msrA msrA recJ recJ nfo nfo EF_1750 EF_1750 comFA comFA EF_1978 EF_1978 EF_2128 EF_2128 EF_2131 EF_2131 EF_2322 EF_2322 recO recO comEA comEA EF_2481 EF_2481 mutY mutY exoA exoA EF_2738 EF_2738 dinP dinP recR recR EF_2840 EF_2840 EF_2974 EF_2974 tag-2 tag-2 recG recG hexB hexB hexA hexA recA recA EF_3173 EF_3173 EF_3218 EF_3218 EF_3241 EF_3241 EF_3242 EF_3242
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (375 aa)
ssb-1Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (188 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (338 aa)
EF_0109ThiJ/PfpI family protein; Similar to GP:6683550; identified by sequence similarity; putative. (226 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1189 aa)
EF_0259S4 RNA-binding domain protein; Similar to GB:M97796, SP:Q02363, PID:184552, and PID:471126; identified by sequence similarity; putative. (87 aa)
EF_0275Ada regulatory protein, putative; Similar to GB:L07557, GB:X98025, GB:X98027, GB:X98029, GB:X98022, GB:X98024, GB:X98026, GB:X98028, SP:Q05086, PID:178745, GB:L07557, GB:X98025, GB:X98027, GB:X98029, GB:X98022, GB:X98024, GB:X98026, GB:X98028, SP:Q05086, and PID:178745; identified by sequence similarity; putative. (188 aa)
ogtmethylated-DNA--protein-cysteine S-methyltransferase; Similar to GP:9946904; identified by sequence similarity; putative. (143 aa)
tag-1DNA-3-methyladenine glycosylase I; Similar to GP:6434028; identified by sequence similarity; putative. (170 aa)
EF_0325DNA polymerase, putative; Similar to SP:P37965, GB:Z26522, PID:403373, and GB:AL009126; identified by sequence similarity; putative. (653 aa)
sodASuperoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (202 aa)
ssb-2Single-strand binding protein; Similar to GP:5001700, and GP:9789553; identified by sequence similarity; putative. (152 aa)
ssb-3Single-strand binding protein; Similar to GP:8248160; identified by sequence similarity; putative. (138 aa)
EF_0655Nitroreductase family protein, putative; Identified by match to PFAM protein family HMM PF00881. (198 aa)
EF_0659Phage SPO1 DNA polymerase-related protein, putative; Identified by match to PFAM protein family HMM PF03167. (216 aa)
EF_0682DNA repair exonuclease family protein; Similar to SP:P80102; identified by sequence similarity; putative. (411 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (676 aa)
uvrBExcinuclease ABC, subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (665 aa)
uvrAExcinuclease ABC, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa)
EF_0780Identified by match to TIGR protein family HMM TIGR00586. (135 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (882 aa)
fpgformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (280 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (226 aa)
EF_0971Conserved hypothetical protein; Similar to GB:M20471, SP:P09496, and PID:179397; identified by sequence similarity; putative. (150 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (557 aa)
drrCDaunorubicin resistance protein; Similar to GB:D31887, and PID:505102; identified by sequence similarity; putative. (745 aa)
EF_1080ImpB/MucB/SamB family protein; Similar to GP:2696022; identified by sequence similarity; putative; Belongs to the DNA polymerase type-Y family. (438 aa)
rexBExonuclease RexB; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. (1196 aa)
rexAExonuclease RexA; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1264 aa)
EF_1130Hexulose-6-phosphate isomerase SgbU, putative; Identified by match to TIGR protein family HMM TIGR00542. (286 aa)
recURecombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (205 aa)
EF_1165Conserved hypothetical protein; Similar to SP:P08063, PID:154718, PID:154801, SP:P08063, PID:154718, and PID:154801; identified by sequence similarity; putative; Belongs to the UPF0234 family. (164 aa)
trxBThioredoxin reductase; Similar to SP:P80880, GB:M94225, SP:Q02420, and PID:153745; identified by sequence similarity; putative. (304 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (788 aa)
uvrCExcinuclease ABC, subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (598 aa)
EF_1435Recombination protein U, putative; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Belongs to the RecU family. (166 aa)
lexATranscriptional repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (209 aa)
EF_1587Identified by match to PFAM protein family HMM PF00293. (190 aa)
EF_1595Identified by match to TIGR protein family HMM TIGR00586; Belongs to the Nudix hydrolase family. (141 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (171 aa)
recJsingle-stranded-DNA-specific exonuclease RecJ; Similar to GP:10173856; identified by sequence similarity; putative. (770 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (297 aa)
EF_1750Endo/excinuclease amino terminal domain protein; Similar to GB:M23197, SP:P20138, and PID:180098; identified by sequence similarity; putative. (320 aa)
comFACompetence protein F; Similar to GB:L07033, SP:P35914, PID:1292941, PID:184503, GB:L07033, SP:P35914, PID:1292941, and PID:184503; identified by sequence similarity; putative. (438 aa)
EF_1978DNA-3-methyladenine glycosylase; Identified by match to PFAM protein family HMM PF02245; Belongs to the DNA glycosylase MPG family. (229 aa)
EF_2128Conserved hypothetical protein; Similar to GP:7248467; identified by sequence similarity; putative. (141 aa)
EF_2131Conserved hypothetical protein; Identified by match to TIGR protein family HMM TIGR00372. (270 aa)
EF_2322Conserved domain protein; Similar to GP:8100669, and GP:8100669; identified by sequence similarity; putative. (434 aa)
recODNA repair protein RecO, putative; Involved in DNA repair and RecF pathway recombination. (262 aa)
comEACompetence protein comEA; Identified by match to PFAM protein family HMM PF00633. (214 aa)
EF_2481Hydrolase, haloacid dehalogenase-like family; Similar to GP:3341431; identified by sequence similarity; putative. (243 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (394 aa)
exoAExodeoxyribonuclease; Similar to GB:D10704, SP:P35790, and PID:219541; identified by sequence similarity; putative. (251 aa)
EF_2738Thioredoxin reductase/glutathione-related protein; Similar to SP:Q05741, GB:M14218, GB:M57638, GB:Y00753, PID:179083, and PID:179087; identified by sequence similarity; putative. (560 aa)
dinPDNA-damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (372 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
EF_2840Conserved hypothetical protein; Identified by match to TIGR protein family HMM TIGR00372. (267 aa)
EF_2974MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (702 aa)
tag-2DNA-3-methyladenine glycosylase I; Identified by match to PFAM protein family HMM PF03352. (183 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (678 aa)
hexBDNA mismatch repair protein HexB; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (710 aa)
hexADNA mismatch repair protein HexA; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (858 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
EF_3173Identified by match to TIGR protein family HMM TIGR01742. (401 aa)
EF_3218Mutator MutT protein, putative; Similar to SP:P25262, SP:P25266, and PID:43471; identified by sequence similarity; putative. (138 aa)
EF_3241Abortive phage resistance protein, putative; Similar to GB:Z36909, and PID:535280; identified by sequence similarity; putative. (210 aa)
EF_3242Abortive phage resistance protein, putative; Similar to GB:Z36909, PID:535280, GB:Z36909, and PID:535280; identified by sequence similarity; putative. (431 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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