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sodA sodA fhuG fhuG EF_2662 EF_2662 pyrC pyrC pyraB pyraB pyrF pyrF pyrE pyrE EF_1084 EF_1084 codY codY dnaJ dnaJ dnaK dnaK grpE grpE fba fba EF_1058 EF_1058 pyrB pyrB ccpA ccpA eno eno EF_1982 EF_1982 hrcA hrcA EF_3035 EF_3035
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
sodASuperoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (202 aa)
fhuGFerrichrome ABC transporter, permease protein; Similar to SP:P49937, GB:U10998, GB:U10999, GB:U11000, GB:U11001, GB:U11002, GB:U11003, GB:U11004, GB:U11005, GB:X80910, SP:P08129, SP:P37140, PID:506772, and PID:531476; identified by sequence similarity; putative; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (334 aa)
EF_2662Choline binding protein; Similar to GP:9454349, GP:9454349, and GP:9454351; identified by sequence similarity; putative. (373 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (427 aa)
pyraBCarbamoyl-phosphate synthase, large subunit; Similar to GP:2598551, and SP:P25994; identified by sequence similarity; putative. (1060 aa)
pyrFOrotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
EF_1084Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. (143 aa)
codYTranscriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (260 aa)
dnaJdnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (389 aa)
dnaKDnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (609 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (179 aa)
fbaFructose-bisphosphate aldolase class-II; Similar to SP:O65944; identified by sequence similarity; putative. (289 aa)
EF_1058Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. (141 aa)
pyrBAspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
ccpACatabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative. (333 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
EF_1982Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. (157 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (347 aa)
EF_3035Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. (151 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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