node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EF_1058 | EF_3035 | EF_1058 | EF_3035 | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | 0.427 |
EF_1058 | sodA | EF_1058 | EF_0463 | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.405 |
EF_1982 | sodA | EF_1982 | EF_0463 | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.426 |
EF_3035 | EF_1058 | EF_3035 | EF_1058 | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | 0.427 |
EF_3035 | sodA | EF_3035 | EF_0463 | Universal stress protein family; Similar to GP:10175807; identified by sequence similarity; putative. | Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.426 |
ccpA | codY | EF_1741 | EF_1645 | Catabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative. | Transcriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.811 |
ccpA | eno | EF_1741 | EF_1961 | Catabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.468 |
codY | ccpA | EF_1645 | EF_1741 | Transcriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Catabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative. | 0.811 |
dnaJ | dnaK | EF_1310 | EF_1308 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
dnaJ | fba | EF_1310 | EF_1167 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Fructose-bisphosphate aldolase class-II; Similar to SP:O65944; identified by sequence similarity; putative. | 0.546 |
dnaJ | grpE | EF_1310 | EF_1307 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.997 |
dnaJ | hrcA | EF_1310 | EF_1306 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.975 |
dnaJ | sodA | EF_1310 | EF_0463 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.751 |
dnaK | dnaJ | EF_1308 | EF_1310 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.999 |
dnaK | eno | EF_1308 | EF_1961 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.746 |
dnaK | grpE | EF_1308 | EF_1307 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.999 |
dnaK | hrcA | EF_1308 | EF_1306 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.994 |
dnaK | pyraB | EF_1308 | EF_1716 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Carbamoyl-phosphate synthase, large subunit; Similar to GP:2598551, and SP:P25994; identified by sequence similarity; putative. | 0.481 |
dnaK | sodA | EF_1308 | EF_0463 | Dnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. | 0.548 |
eno | ccpA | EF_1961 | EF_1741 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Catabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative. | 0.468 |