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purF purF mltF mltF luxS luxS dnaK dnaK gdhA gdhA pgi pgi pyrF pyrF pyrD-2 pyrD-2 pyrB pyrB pyrR pyrR purD purD pgk pgk asnS asnS groEL groEL pfs pfs
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (479 aa)
mltFPTS system, mannitol-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (145 aa)
luxSAutoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (152 aa)
dnaKDnak protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (609 aa)
gdhAGlutamate dehydrogenase; Similar to GP:10174720; identified by sequence similarity; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)
pgiGlucose-6-phosphate isomerase; Similar to GP:4928281, SP:P80860, and SP:P80860; identified by sequence similarity; putative. (449 aa)
pyrFOrotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrD-2Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. (312 aa)
pyrBAspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
pyrRPyrimidine operon regulatory protein PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, by binding to the anti-antiterminator region of the 5' leader on pyr mRNA. This probably favors formation of a transcription terminator hairpin, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa)
purDPhosphoribosylamine--glycine ligase; Similar to SP:P12039; identified by sequence similarity; putative; Belongs to the GARS family. (415 aa)
pgkPhosphoglycerate kinase; Similar to SP:Q9Z5C4, SP:P13954, GB:Y07536, PID:46552, and PID:46749; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family. (397 aa)
asnSasparaginyl-tRNA synthetase; Similar to GB:X03795, GB:M19989, GB:M21571, GB:M19984, GB:M19985, GB:M19986, GB:M19987, GB:M19988, GB:A09204, GB:S62078, SP:P04085, PID:2294398, PID:2294423, PID:2297381, PID:35364, PID:35366, PID:387007, PID:387008, and PID:412189; identified by sequence similarity; putative. (450 aa)
groELChaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
pfsMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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