Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Identified by match to PFAM protein family HMM PF02901.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Nucleoside diphosphate kinase; Similar to SP:P24326, GB:X57315, and PID:1573320; identified by sequence similarity; putative.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

comE operon protein 2, putative; Similar to GP:10173950, GB:M14624, and PID:177203; identified by sequence similarity; putative.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Anaerobic ribonucleoside-triphosphate reductase; Similar to GP:4098081, and GP:4098081; identified by sequence similarity; putative.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Thymidine kinase; Similar to GB:Z24680, SP:Q14392, and PID:439296; identified by sequence similarity; putative.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.

Identified by match to PFAM protein family HMM PF02901.

Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Identified by match to PFAM protein family HMM PF02901.

comE operon protein 2, putative; Similar to GP:10173950, GB:M14624, and PID:177203; identified by sequence similarity; putative.

Identified by match to PFAM protein family HMM PF02901.

2',3'-cyclic-nucleotide 2'-phosphodiesterase, putative; Similar to SP:P08331; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.

Identified by match to PFAM protein family HMM PF02901.

Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.

Identified by match to PFAM protein family HMM PF02901.

Cytidylate kinase; Similar to GB:X56351, SP:P13196, and PID:28583; identified by sequence similarity; putative.

Identified by match to PFAM protein family HMM PF02901.

Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Identified by match to PFAM protein family HMM PF02901.

Purine nucleoside phosphorylase; Similar to SP:P37623, PID:466611, GB:U00096, and PID:1789886; identified by sequence similarity; putative.

Identified by match to PFAM protein family HMM PF02901.

Pyrimidine-nucleoside phosphorylase; Identified by match to PFAM protein family HMM PF02885.

Identified by match to PFAM protein family HMM PF02901.

Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.

Identified by match to PFAM protein family HMM PF02901.

Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.

Identified by match to PFAM protein family HMM PF02901.

Pyrimidine operon regulatory protein PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, by binding to the anti-antiterminator region of the 5' leader on pyr mRNA. This probably favors formation of a transcription terminator hairpin, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.