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dnaA dnaA mprF mprF kdpA kdpA kdpB kdpB kdpC kdpC kdpD kdpD EF_0571 EF_0571 rpoN rpoN EF_0856 EF_0856 vicR vicR vicK vicK EF_1206 EF_1206 EF_1207 EF_1207 phoP phoP EF_1704 EF_1704 EF_1705 EF_1705 EF_1759 EF_1759 EF_1820 EF_1820 agrBfs agrBfs fsrA fsrA EF_2049 EF_2049 EF_2050 EF_2050 cydB cydB cydA cydA glnA glnA EF_2218 EF_2218 EF_2219 EF_2219 vanX vanX vanB vanB vanHB vanHB vanW vanW vanYB vanYB vanSB vanSB vanRB vanRB EF_2556 EF_2556 EF_2630 EF_2630 dltD dltD dltC dltC dtlB dtlB dltA dltA EF_2911 EF_2911 EF_2912 EF_2912 EF_2913 EF_2913 EF_2917 EF_2917 phoZ phoZ htrA htrA EF_3058 EF_3058 lrgB lrgB EF_3194 EF_3194 lytT lytT lytS lytS citG citG EF_3316 EF_3316 citX citX citF citF citE citE citD citD citC citC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (447 aa)
mprFMembrane protein, putative; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (863 aa)
kdpAPotassium-transporting ATPase, subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (558 aa)
kdpBPotassium-transporting ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (676 aa)
kdpCPotassium-transporting ATPase, subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (176 aa)
kdpDSensor histidine kinase KdpD; Similar to GB:D13184, SP:Q08784, PID:602761, GB:D13184, SP:Q08784, and PID:602761; identified by sequence similarity; putative. (850 aa)
EF_0571DNA-binding response regulator; Similar to GB:D13184, SP:Q08784, PID:602761, SP:Q02940, and PID:151433; identified by sequence similarity; putative. (229 aa)
rpoNRNA polymerase sigma-54 factor; Similar to GB:S51768, GB:D13510, GB:L15533, GB:X68641, SP:Q06141, PID:189601, PID:285971, PID:312807, PID:482909, GB:D00937, SP:P33651, PID:216998, and PID:46881; identified by sequence similarity; putative. (437 aa)
EF_0856Aldo/keto reductase family protein; Similar to GP:5106364; identified by sequence similarity; putative. (250 aa)
vicRDNA-binding response regulator VicR; Enterococcus facaelis VicR ORF may be annotated incorrectly in AJ012050. The DNA sequences are identical, thus AJ012050 also contains two in-frame stop codons upstream of start site used in ORF03244, and there is an RBS found near the start site for ORF03244; similar to GP:6687469, and GP:5114230; identified by sequence similarity; putative. (234 aa)
vicKSensory box histidine kinase VicK; Similar to GP:6687470; identified by sequence similarity; putative. (609 aa)
EF_1206Malate dehydrogenase, decarboxylating; Similar to GP:1006839, and GP:1006839; identified by sequence similarity; putative. (389 aa)
EF_1207Citrate carrier protein, CCS family; Similar to GP:1146122; identified by sequence similarity; putative. (441 aa)
phoPAlkaline phosphatase synthesis transcriptional regulatory protein PhoP; Similar to GP:10175779, GB:M18391, GB:Z27409, SP:P21709, PID:339717, and PID:482917; identified by sequence similarity; putative. (236 aa)
EF_1704Sensory box histidine kinase; Similar to GP:10175778; identified by sequence similarity; putative. (591 aa)
EF_1705Identified by match to PFAM protein family HMM PF03466. (296 aa)
EF_1759Phosphate ABC transporter, phosphate-binding protein; Identified by match to TIGR protein family HMM TIGR00975. (284 aa)
EF_1820Histidine kinase, putative; Similar to GP:6492220, and GP:6492220; identified by sequence similarity; putative. (447 aa)
agrBfsagrBfs protein; May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor required for the regulation of the virulence genes for gelatinase (gelE) and a serine protease (sprE). Belongs to the AgrB family. (242 aa)
fsrAResponse regulator; Similar to GP:2564260, GB:X70340, GB:K03222, SP:P01135, PID:183080, PID:339538, PID:339546, and PID:37090; identified by sequence similarity; putative. (243 aa)
EF_2049ABC transporter, permease protein, putative; Similar to GB:M19364, SP:P07316, PID:181099, and PID:181118; identified by sequence similarity; putative. (609 aa)
EF_2050ABC transporter, ATP-binding protein; Similar to SP:P42423; identified by sequence similarity; putative. (249 aa)
cydBCytochrome d ubiquinol oxidase, subunit II; Similar to GB:X59066, GB:X65460, GB:D28126, GB:D14710, SP:P25705, PID:28938, PID:34468, PID:559317, and PID:559325; identified by sequence similarity; putative. (337 aa)
cydACytochrome d ubiquinol oxidase, subunit I; Similar to SP:P11026; identified by sequence similarity; putative. (472 aa)
glnAGlutamine synthetase, type I; Identified by match to PFAM protein family HMM PF03951. (446 aa)
EF_2218DNA-binding response regulator, AraC family; Similar to GP:10173407, and GP:10173407; identified by sequence similarity; putative. (493 aa)
EF_2219Sensor histidine kinase; Similar to GP:5830535; identified by sequence similarity; putative. (570 aa)
vanXD-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. Belongs to the peptidase M15D family. (202 aa)
vanBD-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding. (342 aa)
vanHBD-specific alpha-keto acid dehydrogenase; Required for high-level resistance to glycopeptides antibiotics. Catalyzes the reduction of 2-keto acids to 2-D-hydroxy acids that give rise to peptidoglycan precursors that terminate in the depsipeptide D-alanine-2-lactate rather than the dipeptide D-alanine-D- alanine thus preventing vancomycin binding; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
vanWVancomycin B-type resistance protein VanW; Similar to GB:M94362, GB:M94363, SP:Q03252, PID:1054874, GB:M94362, GB:M94363, SP:Q03252, and PID:1054874; identified by sequence similarity; putative. (275 aa)
vanYBD-alanyl-D-alanine carboxypeptidase; Carboxypeptidase that cleaves the C-terminal D-alanine residue from the peptidoglycan-derived pentapeptide L-Ala-gamma-D-Glu- L-Lys-D-Ala-D-Ala in vitro. Therefore, should contribute in vivo to the hydrolysis of the D-alanyl-D-alanine-containing peptidoglycan precursors. May increase the level of glycopeptide antibiotics resistance by decreasing the availability of D-Ala-D-Ala termini from the cell surface, which constitute the antibiotic target residues. (268 aa)
vanSBSensor histidine kinase VanSB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates VanR by phosphorylation. (447 aa)
vanRBDNA-binding response regulator VanRB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. (220 aa)
EF_2556Fumarate reductase flavoprotein subunit precursor, putative; Similar to GP:6573307, GB:D00210, GB:M16552, GB:X05495, GB:J02973, GB:M74564, SP:P07204, PID:220127, PID:339657, PID:339659, and PID:736251; identified by sequence similarity; putative; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (505 aa)
EF_2630Transcriptional regulator; Similar to GP:6689205; identified by sequence similarity; putative. (174 aa)
dltDdltD protein; Similar to GP:6456613, GB:D00726, SP:P22830, and PID:219656; identified by sequence similarity; putative. (424 aa)
dltCD-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (78 aa)
dtlBBasic membrane protein DtlB; Could be involved in the transport of activated D-alanine through the membrane. (400 aa)
dltAD-alanine-activating enzyme, putative; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dep [...] (506 aa)
EF_2911DNA-binding response regulator, LuxR family; Similar to GP:5830527, and GP:9501772; identified by sequence similarity; putative. (210 aa)
EF_2912Sensor histidine kinase, putative; Similar to GB:L35044, and PID:516627; identified by sequence similarity; putative. (367 aa)
EF_2913Conserved hypothetical protein; Similar to GP:9501770, and GP:16413478; identified by sequence similarity; putative. (243 aa)
EF_2917UDP-N-acetylglucosamine 2-epimerase; Similar to SP:P27828; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (382 aa)
phoZAlkaline phosphatase; Similar to GP:5020414, SP:P19405, and GP:5020414; identified by sequence similarity; putative; Belongs to the alkaline phosphatase family. (471 aa)
htrASerine protease DO; Similar to GP:7363330, and GP:7363330; identified by sequence similarity; putative. (432 aa)
EF_3058Phosphotyrosine protein phosphatase; Similar to GP:10174857, GB:X75958, PID:473008, and PID:530791; identified by sequence similarity; putative; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (156 aa)
lrgBLrgB family protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. (227 aa)
EF_3194LrgA family protein; Identified by match to PFAM protein family HMM PF03788. (139 aa)
lytTResponse regulator; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. (242 aa)
lytSSensor histidine kinase; Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. (589 aa)
citGCitG family protein; Similar to SP:O53080, SP:P35076, GB:X64876, and PID:580818; identified by sequence similarity; putative. (289 aa)
EF_3316Malic enzyme family protein; Similar to GP:6249490; identified by sequence similarity; putative. (390 aa)
citXApo-citrate lyase pyrophosphoribosyl-dephosph-CoA transferase; Similar to SP:O53080, SP:P35076, GB:X64876, and PID:580818; identified by sequence similarity; putative. (178 aa)
citFCitrate lyase, alpha subunit; Similar to SP:O53079, SP:P10805, GB:X13548, PID:41354, GB:U00096, PID:1651235, PID:1778480, and PID:1786778; identified by sequence similarity; putative. (470 aa)
citECitrate lyase, beta subunit; Similar to SP:O53078, and SP:P77770; identified by sequence similarity; putative; Belongs to the HpcH/HpaI aldolase family. (295 aa)
citDCitrate lyase, gamma subunit; Covalent carrier of the coenzyme of citrate lyase. (102 aa)
citCCitrate lyase ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (336 aa)
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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