STRINGSTRING
cysK cysK cysK-2 cysK-2 BC_1964 BC_1964 thrC thrC thrB thrB mtnN mtnN BC_2548 BC_2548 metE metE BC_4034 BC_4034 BC_4035 BC_4035 metH metH BC_4251 BC_4251 BC_4253 BC_4253 metC metC BC_4366 BC_4366 BC_4367 BC_4367 mtnN-2 mtnN-2 BC_4369 BC_4369 BC_4653 BC_4653 megL megL BC_4730 BC_4730 metK metK luxS luxS BC_4906 BC_4906 BC_5404 BC_5404 metAA metAA BC_5406 BC_5406
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
cysK-2Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
BC_1964Homoserine dehydrogenase. (431 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa)
mtnNS-Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (240 aa)
BC_2548Homoserine dehydrogenase. (341 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa)
BC_4034Nitrilase. (259 aa)
BC_4035Aspartate aminotransferase. (392 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1133 aa)
BC_42515-methyltetrahydrofolate--homocysteine methyltransferase. (610 aa)
BC_4253Cystathionine gamma-synthase. (370 aa)
metCCystathionine beta-lyase. (387 aa)
BC_4366Cystathionine beta-lyase. (377 aa)
BC_4367Cysteine synthase. (307 aa)
mtnN-2S-Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa)
BC_4369Dimethyladenosine transferase; Could be a S-adenosyl-L-methionine-dependent methyltransferase. (188 aa)
BC_4653GAF domain-containing proteins. (159 aa)
megLMethionine gamma-lyase. (391 aa)
BC_4730Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (374 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa)
luxSAutoinducer-2 production protein luxS / Ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa)
BC_4906Aspartate aminotransferase. (383 aa)
BC_5404Homoserine dehydrogenase. (431 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa)
BC_5406O-acetylhomoserine sulfhydrylase. (421 aa)
Your Current Organism:
Bacillus cereus ATCC 14579
NCBI taxonomy Id: 226900
Other names: B. cereus ATCC 14579, Bacillus cereus (strain ATCC 14579 / DSM 31)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.