(8 nodes) Thiamine metabolic process, and Vitamin B6 biosynthetic process network (Aspergillus nidulans)

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Your Input:
	ANIA_10762	Thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue AFUA_2G10740). (510 aa)
	ANIA_10472	Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970). (519 aa)
	thiA	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (331 aa)
	ANIA_06141	Uncharacterized protein. (271 aa)
	ANIA_08009	Thiamine biosynthesis protein (Eurofung). (341 aa)
	ANIA_05933	Uncharacterized protein. (559 aa)
	ANIA_00270	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900). (328 aa)
	pyroA	Pyridoxal 5'-phosphate synthase subunit pyroA; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers; Belongs to the PdxS/SNZ family. (304 aa)

Your Current Organism:

Aspergillus nidulans

NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANIA_00270	ANIA_05933	Q5BGR0	Q5B0J7	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	Uncharacterized protein.	0.734
ANIA_00270	ANIA_06141	Q5BGR0	G5EB85	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	Uncharacterized protein.	0.954
ANIA_00270	ANIA_08009	Q5BGR0	Q5AUM1	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	Thiamine biosynthesis protein (Eurofung).	0.800
ANIA_00270	ANIA_10762	Q5BGR0	C8V3I9	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	Thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue AFUA_2G10740).	0.734
ANIA_00270	pyroA	Q5BGR0	Q9UW83	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	Pyridoxal 5'-phosphate synthase subunit pyroA; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers; Belongs to the PdxS/SNZ family.	0.923
ANIA_05933	ANIA_00270	Q5B0J7	Q5BGR0	Uncharacterized protein.	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	0.734
ANIA_05933	thiA	Q5B0J7	G5EAZ2	Uncharacterized protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.722
ANIA_06141	ANIA_00270	G5EB85	Q5BGR0	Uncharacterized protein.	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	0.954
ANIA_06141	ANIA_08009	G5EB85	Q5AUM1	Uncharacterized protein.	Thiamine biosynthesis protein (Eurofung).	0.812
ANIA_06141	pyroA	G5EB85	Q9UW83	Uncharacterized protein.	Pyridoxal 5'-phosphate synthase subunit pyroA; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers; Belongs to the PdxS/SNZ family.	0.999
ANIA_06141	thiA	G5EB85	G5EAZ2	Uncharacterized protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.473
ANIA_08009	ANIA_00270	Q5AUM1	Q5BGR0	Thiamine biosynthesis protein (Eurofung).	Pyridoxal kinase, putative (AFU_orthologue AFUA_1G02900).	0.800
ANIA_08009	ANIA_06141	Q5AUM1	G5EB85	Thiamine biosynthesis protein (Eurofung).	Uncharacterized protein.	0.812
ANIA_08009	ANIA_10472	Q5AUM1	C8V6D0	Thiamine biosynthesis protein (Eurofung).	Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970).	0.579
ANIA_08009	ANIA_10762	Q5AUM1	C8V3I9	Thiamine biosynthesis protein (Eurofung).	Thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue AFUA_2G10740).	0.469
ANIA_08009	pyroA	Q5AUM1	Q9UW83	Thiamine biosynthesis protein (Eurofung).	Pyridoxal 5'-phosphate synthase subunit pyroA; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers; Belongs to the PdxS/SNZ family.	0.914
ANIA_08009	thiA	Q5AUM1	G5EAZ2	Thiamine biosynthesis protein (Eurofung).	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.812
ANIA_10472	ANIA_08009	C8V6D0	Q5AUM1	Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970).	Thiamine biosynthesis protein (Eurofung).	0.579
ANIA_10472	ANIA_10762	C8V6D0	C8V3I9	Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970).	Thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue AFUA_2G10740).	0.953
ANIA_10472	thiA	C8V6D0	G5EAZ2	Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970).	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.655