STRINGSTRING
ANIA_07063 ANIA_07063 mdpC mdpC mdpE mdpE mdpG mdpG ANIA_01616 ANIA_01616 ANIA_01617 ANIA_01617 ANIA_02118 ANIA_02118 ANIA_02558 ANIA_02558 ANIA_02787 ANIA_02787 ANIA_02788 ANIA_02788 ANIA_04831 ANIA_04831 ANIA_05260 ANIA_05260 ANIA_05326 ANIA_05326 ANIA_05400 ANIA_05400 ANIA_05565 ANIA_05565 ANIA_05887 ANIA_05887 ANIA_06167 ANIA_06167 ANIA_06683 ANIA_06683 napA napA ANIA_07817 ANIA_07817 ANIA_07855 ANIA_07855 orsA orsA orsB orsB ANIA_07933 ANIA_07933 ANIA_08757 ANIA_08757 ANIA_09282 ANIA_09282 stcF stcF stcB stcB stcA stcA stcU stcU fadA fadA stcW stcW stcV stcV stcT stcT stcS stcS stcQ stcQ stcO stcO stcL stcL stcK stcK stcJ stcJ stcI stcI stcE stcE stcC stcC aflR aflR fluG fluG flbA flbA brlA brlA ppoA ppoA velB velB ANIA_01300 ANIA_01300 ANIA_10110 ANIA_10110 ANIA_09210 ANIA_09210 ANIA_10704 ANIA_10704 ANIA_07812 ANIA_07812 ANIA_08645 ANIA_08645 ANIA_10860 ANIA_10860 tdiE tdiE tdiB tdiB mcsA mcsA ANIA_00025 ANIA_00025
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ANIA_07063Uncharacterized protein; Belongs to the FMO family. (551 aa)
mdpCShort chain dehydrogenase mdpC; Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that cataly [...] (265 aa)
mdpEMonodictyphenone cluster transcription factor; Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. (435 aa)
mdpGAtrochrysone carboxylic acid synthase; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase md [...] (1806 aa)
ANIA_01616Uncharacterized protein. (404 aa)
ANIA_01617Aldo_ket_red domain-containing protein. (120 aa)
ANIA_02118Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (337 aa)
ANIA_02558Flavin-binding monooxygenase, putative (AFU_orthologue AFUA_3G15050). (610 aa)
ANIA_02787Uncharacterized protein. (153 aa)
ANIA_02788Uncharacterized protein. (247 aa)
ANIA_04831Aryl-alcohol dehydrogenase Aad14, putative (AFU_orthologue AFUA_2G11250). (384 aa)
ANIA_05260Uncharacterized protein. (550 aa)
ANIA_05326Abhydrolase_3 domain-containing protein. (236 aa)
ANIA_05400Flavin-binding monooxygenase, putative (AFU_orthologue AFUA_6G13790). (568 aa)
ANIA_05565Abhydrolase_3 domain-containing protein. (335 aa)
ANIA_05887Hypothetical aryl alcohol dehydrogenase (Eurofung). (384 aa)
ANIA_06167FMN binding oxidoreductase, putative (AFU_orthologue AFUA_2G08260). (369 aa)
ANIA_06683Uncharacterized protein. (503 aa)
napAAP-1-like transcription factor napA; Transcription activator involved in oxidative stress response, specifically during hyphal growth. Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways including the mycelium-specific catalase catB (but not the conidia-specific catalase catA), thioredoxin reductase trxB and thioredoxin thiO. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the [...] (577 aa)
ANIA_07817Uncharacterized protein. (305 aa)
ANIA_07855Fatty acid synthetase beta subunit, putative (JCVI). (583 aa)
orsAOrsellinic acid synthase; Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B. (2103 aa)
orsBDecarboxylase orsB; Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B. Belongs to the metallo-dependent [...] (331 aa)
ANIA_07933Uncharacterized protein. (335 aa)
ANIA_08757Uncharacterized protein; Belongs to the FMO family. (586 aa)
ANIA_09282Flavin-binding monooxygenase, putative (AFU_orthologue AFUA_6G03020). (642 aa)
stcFProbable sterigmatocystin biosynthesis P450 monooxygenase stcF; May be involved in the hydroxylation of averantin to form 5'- hydroxyaverantin, oxidation of averufin to 1-hydroxyversicolorone and its oxidation to versiconal hemiacetal acetate. (483 aa)
stcBProbable sterigmatocystin biosynthesis P450 monooxygenase STCB; May be involved in the hydroxylation of averantin to form 5'- hydroxyaverantin, oxidation of averufin to 1-hydroxyversicolorone and its oxidation to versiconal hemiacetal acetate. (517 aa)
stcAPutative sterigmatocystin biosynthesis polyketide synthase; Involved in the synthesis of the polyketide nucleus of sterigmatocystin from hexanoyl-CoA and seven malonates. (2211 aa)
stcUVersicolorin reductase; Catalyzes the conversion of versicolorin A to sterigmatocystin; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
fadAGuanine nucleotide-binding protein subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (353 aa)
stcWPutative sterigmatocystin biosynthesis monooxygenase stcW; May be involved in the hydroxylation of averantin to form 5'- hydroxyaverantin, oxidation of averufin to 1-hydroxyversicolorone and its oxidation to versiconal hemiacetal acetate. (601 aa)
stcVPutative sterigmatocystin biosynthesis dehydrogenase stcV; May be involved in the dehydration of 5'-hydroxyaverantin to form averufin; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. (387 aa)
stcTPutative sterigmatocystin biosynthesis protein stcT. (215 aa)
stcSProbable sterigmatocystin biosynthesis P450 monooxygenase stcS; Catalyzes the conversion of versicolorin A to demethylsterigmatocystin. (488 aa)
stcQAverufin oxidase A homolog; Involved in the conversion of averufin (AVF) to versiconal hemiacetal acetate (VHA); Belongs to the avfA family. (274 aa)
stcOAverufin oxidase A homolog; Involved in the conversion of averufin (AVF) to versiconal hemiacetal acetate (VHA); Belongs to the avfA family. (297 aa)
stcLVersicolorin B desaturase; Required for bisfuran desaturation during sterigmatocystin biosynthesis by catalyzing the conversion of versicolorin B to versicolorin A; Belongs to the cytochrome P450 family. (496 aa)
stcKPutative sterigmatocystin biosynthesis fatty acid synthase subunit beta; Involved in the synthesis of sterigmatocystin. May be involved in the synthesis of a six-carbon fatty acid that serves to initiate polyketide synthesis; Belongs to the fungal fatty acid synthetase subunit beta family. (1914 aa)
stcJSterigmatocystin biosynthesis fatty acid synthase subunit alpha; Required for the synthesis of sterigmatocystin, a polyketide, but not for primary fatty acid metabolism. Involved in the synthesis of a six-carbon fatty acid that serves to initiate the polyketide synthesis. (1559 aa)
stcIPutative sterigmatocystin biosynthesis lipase/esterase stcI; May be involved in the conversion of versiconal hemiacetal acetate to versiconal; Belongs to the 'GDXG' lipolytic enzyme family. (286 aa)
stcEPutative sterigmatocystin biosynthesis ketoreductase stcE; May be involved in the dehydration of norsolorinic acid to form averantin; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
stcCPutative sterigmatocystin biosynthesis peroxidase stcC. (305 aa)
aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)
fluGProtein fluG; May function as a GSI-related enzyme in synthesizing a small diffusible factor that acts as an extracellular signal directing asexual sporulation and perhaps other aspects of colony growth. May be involved in brlA activation (an early transcriptional regulator for conidiation specific gene); Belongs to the glutamine synthetase family. (865 aa)
flbADevelopmental regulator flbA; Required for asexual sporulation and normal colony development. May be involved in brlA activation. Could play a regulatory role in controlling the flug-initiated signal transduction pathway that triggers the asexual reproduction. (719 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...] (432 aa)
ppoA9,12-octadecadienoate 8-hydroperoxide 8R-isomerase; Bifunctional heme-containing enzyme that oxidizes linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (within the N- terminal heme peroxidase domain), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (within the C- terminal P450 heme thiolate domain). Oxidized unsaturated fatty acids, so-called oxylipins, derived from endogenous fatty acids, influence the development of the asexual conidiophores and sexual cleistothecia and regulate the secondary metabolism. These substances were coll [...] (1081 aa)
velBVelvet complex subunit B; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA th [...] (369 aa)
ANIA_01300Short chain dehydrogenase/reductase family oxidoreductase (JCVI). (260 aa)
ANIA_10110Hydantoin racemase (Dcg1), putative (AFU_orthologue AFUA_1G13380). (295 aa)
ANIA_09210Cytochrome P450, putative (Eurofung). (517 aa)
ANIA_10704Cytochrome P450, putative (Eurofung). (548 aa)
ANIA_07812PAS domain-containing protein. (639 aa)
ANIA_08645Putative Zn(II)2Cys6 transcription factor (Eurofung). (462 aa)
ANIA_10860Aldo_ket_red domain-containing protein. (172 aa)
tdiEProbable methyltransferase tdiE; Probable methyltransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. TdiA then immediately converts unstable IDA to didemethylasterriquinone D (DDAQ D). TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquino [...] (317 aa)
tdiBIndole prenyltransferase tdiB; Indole prenyltransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. TdiA then immediately converts unstable IDA to didemethylasterriquinone D (DDAQ D). TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C [...] (419 aa)
mcsA2-methylcitrate synthase, mitochondrial; Catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate and also from acetyl-CoA and oxaloacetate with a greater efficiency. Also has citrate synthase activity and can substitute for the loss of citA activity. (460 aa)
ANIA_00025Uncharacterized protein. (603 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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