STRINGSTRING
ANIA_09529 ANIA_09529 ANIA_06496 ANIA_06496 ANIA_10827 ANIA_10827 ANIA_06162 ANIA_06162 ANIA_10529 ANIA_10529 ANIA_04031 ANIA_04031 ANIA_09460 ANIA_09460 ANIA_10439 ANIA_10439 ANIA_10465 ANIA_10465 ANIA_11231 ANIA_11231 ANIA_10611 ANIA_10611 ANIA_11129 ANIA_11129 ANIA_11133 ANIA_11133 ANIA_11232 ANIA_11232 ANIA_06975 ANIA_06975 ANIA_06973 ANIA_06973 ANIA_10987 ANIA_10987 ANIA_10874 ANIA_10874 ANIA_10877 ANIA_10877 cyn1 cyn1 ANIA_11019 ANIA_11019 ANIA_11081 ANIA_11081 ANIA_05107 ANIA_05107 ANIA_10639 ANIA_10639 ANIA_10648 ANIA_10648 ANIA_05788 ANIA_05788 ANIA_10367 ANIA_10367 ANIA_10247 ANIA_10247 ANIA_01933 ANIA_01933 ANIA_08907 ANIA_08907 ANIA_10191 ANIA_10191 ANIA_01455 ANIA_01455 ANIA_02464 ANIA_02464 ANIA_00235 ANIA_00235 ANIA_00930 ANIA_00930 ANIA_05105 ANIA_05105 ubp16 ubp16 ANIA_09462 ANIA_09462 ANIA_09275 ANIA_09275 ausE ausE ANIA_09167 ANIA_09167 ANIA_08258 ANIA_08258 ANIA_08117 ANIA_08117 ANIA_08070 ANIA_08070 ANIA_08018 ANIA_08018 atnI atnI ANIA_07721 ANIA_07721 ANIA_07715 ANIA_07715 ANIA_07575 ANIA_07575 ANIA_07472 ANIA_07472 ANIA_07426 ANIA_07426 ANIA_07302 ANIA_07302 alg8 alg8 ANIA_07282 ANIA_07282 cdc48 cdc48 ANIA_06941 ANIA_06941 ANIA_06913 ANIA_06913 rot1 rot1 ANIA_06627 ANIA_06627 ANIA_06610 ANIA_06610 ANIA_06606 ANIA_06606 ANIA_06602 ANIA_06602 ANIA_06532 ANIA_06532 ANIA_06528 ANIA_06528 ANIA_06435 ANIA_06435 ANIA_06269 ANIA_06269 ANIA_06136 ANIA_06136 ANIA_06071 ANIA_06071 ANIA_05951 ANIA_05951 alg10 alg10 ANIA_05900 ANIA_05900 ANIA_05888 ANIA_05888 ANIA_05862 ANIA_05862 AN5861 AN5861 ANIA_05819 ANIA_05819 ANIA_05736 ANIA_05736 ANIA_05725 ANIA_05725 ANIA_04966 ANIA_04966 ANIA_04766 ANIA_04766 ANIA_04761 ANIA_04761 ANIA_04728 ANIA_04728 ANIA_04683 ANIA_04683 ANIA_04674 ANIA_04674 ANIA_04589 ANIA_04589 ANIA_04441 ANIA_04441 ANIA_04406 ANIA_04406 ANIA_04332 ANIA_04332 ANIA_03833 ANIA_03833 ANIA_03826 ANIA_03826 ANIA_03759 ANIA_03759 ANIA_03728 ANIA_03728 ANIA_03475 ANIA_03475 ANIA_03177 ANIA_03177 sec11 sec11 ANIA_02684 ANIA_02684 ANIA_02573 ANIA_02573 ANIA_02069 ANIA_02069 ANIA_02056 ANIA_02056 ANIA_01968 ANIA_01968 ANIA_01775 ANIA_01775 ANIA_01683 ANIA_01683 ANIA_01526 ANIA_01526 ANIA_01525 ANIA_01525 ANIA_01488 ANIA_01488 ANIA_01459 ANIA_01459 ANIA_01442 ANIA_01442 AN1412 AN1412 ANIA_01161 ANIA_01161 ANIA_01102 ANIA_01102 chs7 chs7 ANIA_01039 ANIA_01039 PSD1 PSD1 ANIA_00871 ANIA_00871 ANIA_00834 ANIA_00834 ANIA_00810 ANIA_00810 ANIA_00640 ANIA_00640 ANIA_00636 ANIA_00636 ANIA_00417 ANIA_00417 ANIA_00405 ANIA_00405 ANIA_00366 ANIA_00366 ANIA_00329 ANIA_00329 ANIA_00315 ANIA_00315 ANIA_00229 ANIA_00229 hacA hacA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANIA_09529DUF1183 domain protein (AFU_orthologue AFUA_6G04410). (308 aa)
ANIA_06496Transferase (Gpi7), putative (AFU_orthologue AFUA_6G05260). (847 aa)
ANIA_10827Uncharacterized protein. (123 aa)
ANIA_06162Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (322 aa)
ANIA_10529Aminotran_1_2 domain-containing protein. (580 aa)
ANIA_04031Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (170 aa)
ANIA_09460Microsomal signal peptidase subunit (Gp23), putative (AFU_orthologue AFUA_5G03220). (247 aa)
ANIA_10439GPI transamidase component (GAA1), putative (AFU_orthologue AFUA_6G12760). (631 aa)
ANIA_10465Rhomboid family protein, putative (AFU_orthologue AFUA_6G12750). (273 aa)
ANIA_11231CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (456 aa)
ANIA_10611N-acetylglucosaminyl transferase component Gpi1 (AFU_orthologue AFUA_3G09860). (665 aa)
ANIA_11129Uncharacterized protein. (379 aa)
ANIA_11133Microsomal signal peptidase Spc12, putative (AFU_orthologue AFUA_5G05800). (91 aa)
ANIA_11232Phosphatidylinositol:UDP-GlcNAc transferase PIG-C (AFU_orthologue AFUA_3G07170). (505 aa)
ANIA_06975UVSB; Belongs to the PI3/PI4-kinase family. (2454 aa)
ANIA_06973C-4 methyl sterol oxidase Erg25, putative (AFU_orthologue AFUA_4G04820); Belongs to the sterol desaturase family. (302 aa)
ANIA_10987TPR_REGION domain-containing protein. (217 aa)
ANIA_10874Ubiquitin-conjugating enzyme Ubc6, putative (AFU_orthologue AFUA_4G04612). (277 aa)
ANIA_10877Ubiquitin fusion degradation protein (Ufd1), putative (AFU_orthologue AFUA_4G04640). (756 aa)
cyn1Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (160 aa)
ANIA_11019Erf4 domain-containing protein. (223 aa)
ANIA_110813Beta_HSD domain-containing protein. (364 aa)
ANIA_05107Uncharacterized protein; Belongs to the CTL (choline transporter-like) family. (745 aa)
ANIA_10639GPI transamidase component PIG-S, putative (AFU_orthologue AFUA_6G07180). (565 aa)
ANIA_10648Sterol reductase (Eurofung). (567 aa)
ANIA_05788Uncharacterized protein. (218 aa)
ANIA_10367Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1221 aa)
ANIA_10247Cytomegalovirus gH-receptor family protein, putative (AFU_orthologue AFUA_2G04390). (1009 aa)
ANIA_01933Evolutionarily conserved protein with similarity to Orm2p (Eurofung). (349 aa)
ANIA_08907C-4 methyl sterol oxidase, putative (AFU_orthologue AFUA_8G02440); Belongs to the sterol desaturase family. (291 aa)
ANIA_10191AAA family ATPase, putative (AFU_orthologue AFUA_8G04270). (1631 aa)
ANIA_01455Uncharacterized protein. (741 aa)
ANIA_02464Ceramide synthase LagA (Eurofung). (439 aa)
ANIA_00235Serine-threonine kinase and endoribonuclease (Eurofung). (1121 aa)
ANIA_00930Auxin efflux transporter family protein (Eurofung). (584 aa)
ANIA_05105Uncharacterized protein. (740 aa)
ubp16Ubiquitin carboxyl-terminal hydrolase 16. (624 aa)
ANIA_09462Uncharacterized protein. (133 aa)
ANIA_09275C-4 methylsterol oxidase, putative (AFU_orthologue AFUA_2G01160); Belongs to the sterol desaturase family. (259 aa)
ausEMultifunctional dioxygenase ausE; Dioxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by ausE vi [...] (298 aa)
ANIA_09167Uncharacterized protein. (358 aa)
ANIA_08258Ubiquitin conjugating enzyme (UbcH), putative (AFU_orthologue AFUA_5G04060); Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
ANIA_08117Elongation of fatty acids protein. (340 aa)
ANIA_08070PIG-P domain-containing protein. (357 aa)
ANIA_08018Auxin efflux transporter family protein (Eurofung). (445 aa)
atnIProbable lipid transporter atnI; Probable lipid transporter; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol). The core structure of aspercryptins is as follows: Ser/Ala-Thr-Ile/Val-2aoa-Asn-2adol. The first step of aspercryptin biosynthesis is the generation of the fatty acid precursors, octanoic and dodecanoic acids, by the FAS subunits atnF and atnM. The fatty acid precursors are likely transform [...] (383 aa)
ANIA_07721Plug_translocon domain-containing protein. (478 aa)
ANIA_07715Dolichyl-phosphate beta-glucosyltransferase, putative (AFU_orthologue AFUA_5G08210). (405 aa)
ANIA_07575C-3 sterol dehydrogenase/C-4 decarboxylase (AFU_orthologue AFUA_2G15030). (410 aa)
ANIA_07472Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (502 aa)
ANIA_07426Oligosaccharyl transferase subunit (Gamma), putative (AFU_orthologue AFUA_2G06280). (127 aa)
ANIA_07302Lectin family integral membrane protein, putative (AFU_orthologue AFUA_2G16800). (419 aa)
alg8Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family. (509 aa)
ANIA_07282APH domain-containing protein. (529 aa)
cdc48Cell division control protein 48; Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated n [...] (823 aa)
ANIA_06941Integral membrane protein (AFU_orthologue AFUA_3G03520). (405 aa)
ANIA_06913Ubiquitin C-terminal hydrolase, putative (AFU_orthologue AFUA_5G13620); Belongs to the peptidase C19 family. (630 aa)
rot1Protein rot1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity); Belongs to the ROT1 family. (234 aa)
ANIA_06627Signal sequence receptor alpha subunit, putative (AFU_orthologue AFUA_6G03850). (636 aa)
ANIA_06610PAP2 domain protein (AFU_orthologue AFUA_6G04240). (238 aa)
ANIA_06606Mannosyl-oligosaccharide glucosidase, putative (AFU_orthologue AFUA_6G04210). (749 aa)
ANIA_06602Short chain dehydrogenase/reductase family protein (AFU_orthologue AFUA_6G04120). (394 aa)
ANIA_06532Short chain dehydrogenase/reductase family protein (AFU_orthologue AFUA_6G04850). (372 aa)
ANIA_06528CaaX protease. (352 aa)
ANIA_06435Elongation of fatty acids protein. (299 aa)
ANIA_06269Translocation protein sec62 (Eurofung). (394 aa)
ANIA_06136RING finger membrane protein (AFU_orthologue AFUA_2G08650). (1573 aa)
ANIA_06071DUF221 domain protein, putative (AFU_orthologue AFUA_2G09070). (1196 aa)
ANIA_05951ER membrane DUF1077 domain protein, putative (AFU_orthologue AFUA_2G10350). (255 aa)
alg10Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (608 aa)
ANIA_05900AMFR protein, putative (AFU_orthologue AFUA_2G11100). (197 aa)
ANIA_05888UDP-N-acetyl-glucosamine-1-P transferase Alg7, putative (AFU_orthologue AFUA_2G11240). (408 aa)
ANIA_05862Ergosterol biosynthesis protein Erg28, putative (AFU_orthologue AFUA_2G11550). (141 aa)
AN5861Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (346 aa)
ANIA_05819SRP receptor beta subunit (Srp102), putative (AFU_orthologue AFUA_2G07600). (317 aa)
ANIA_05736Glycosyltransferase family protein (AFU_orthologue AFUA_6G06940). (301 aa)
ANIA_05725Alpha-1,2-mannosyltransferase (Alg11), putative (AFU_orthologue AFUA_1G06890). (585 aa)
ANIA_04966Uncharacterized protein. (384 aa)
ANIA_04766Uncharacterized protein. (316 aa)
ANIA_04761Protein mannosyltransferase 1 (AFU_orthologue AFUA_3G06450). (918 aa)
ANIA_04728EMC1_C domain-containing protein. (889 aa)
ANIA_04683Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (460 aa)
ANIA_04674ER membrane protein Wsc4, putative (AFU_orthologue AFUA_5G09020). (304 aa)
ANIA_04589Protein translocation complex subunit Sss1, putative (AFU_orthologue AFUA_3G06901). (70 aa)
ANIA_04441ER associated DnaJ chaperone (Hlj1), putative (AFU_orthologue AFUA_4G07330). (339 aa)
ANIA_04406Integral ER membrane protein Scs2, putative (AFU_orthologue AFUA_4G06950). (263 aa)
ANIA_04332Ceramide synthase BarA (Eurofung). (429 aa)
ANIA_03833AB hydrolase-1 domain-containing protein. (417 aa)
ANIA_03826GPI transamidase component PIG-U, putative (AFU_orthologue AFUA_4G08200). (407 aa)
ANIA_03759Sulfhydryl oxidase. (212 aa)
ANIA_03728Serine palmitoyl CoA transferase subunit LCBA. (504 aa)
ANIA_03475HET domain-containing protein. (760 aa)
ANIA_03177Phosphatidate cytidylyltransferase, putative (AFU_orthologue AFUA_3G13270). (381 aa)
sec11Signal peptidase complex catalytic subunit sec11; Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity). (192 aa)
ANIA_02684Sterol reductase (Eurofung). (488 aa)
ANIA_02573Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (313 aa)
ANIA_02069Cytochrome b5, putative (AFU_orthologue AFUA_2G04710); Belongs to the cytochrome b5 family. (136 aa)
ANIA_02056Uncharacterized protein. (436 aa)
ANIA_01968Steroid alpha reductase family protein (AFU_orthologue AFUA_4G10760). (273 aa)
ANIA_01775GPI transamidase component Gpi16, putative (AFU_orthologue AFUA_6G09020). (582 aa)
ANIA_01683Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (290 aa)
ANIA_01526ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (266 aa)
ANIA_01525Signal peptidase complex component, putative (AFU_orthologue AFUA_8G05340). (180 aa)
ANIA_01488RING finger protein (AFU_orthologue AFUA_8G04840). (775 aa)
ANIA_01459Mannosyltransferase PMTI (AFU_orthologue AFUA_8G04500). (773 aa)
ANIA_01442Translocation protein (Sec66), putative (AFU_orthologue AFUA_8G04260). (272 aa)
AN1412Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity); Belongs to the LIMR family. LMBRD1 subfamily. (575 aa)
ANIA_01161Uncharacterized protein. (123 aa)
ANIA_01102Serine palmitoyl transferase subunit. (672 aa)
chs7Chitin synthase export chaperone; Chaperone required for the export of the chitin synthase chs3 from the endoplasmic reticulum. (331 aa)
ANIA_01039Membrane-tethered transcription factor (SPT23), putative (AFU_orthologue AFUA_1G12550). (1393 aa)
PSD1Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. (547 aa)
ANIA_00871GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (397 aa)
ANIA_00834Protein translocation complex componenet (Npl1), putative (AFU_orthologue AFUA_1G14940). (696 aa)
ANIA_00810Ubiquitin-protein ligase Sel1/Ubx2, putative (AFU_orthologue AFUA_1G14690). (1121 aa)
ANIA_00640Sphinganine hydroxylase BasA (Eurofung); Belongs to the sterol desaturase family. (430 aa)
ANIA_00636Uncharacterized protein. (488 aa)
ANIA_00417Translocon protein Sec61beta, putative (AFU_orthologue AFUA_1G04890). (250 aa)
ANIA_00405Uncharacterized protein. (143 aa)
ANIA_00366Uncharacterized protein. (242 aa)
ANIA_00329Ubiquitin fusion degradation protein Ufd1, putative (AFU_orthologue AFUA_1G02430). (393 aa)
ANIA_00315Uncharacterized protein. (234 aa)
ANIA_00229DUF221 domain protein, putative (AFU_orthologue AFUA_5G10920). (875 aa)
hacATranscriptional activator hacA; Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway (By similarity). (350 aa)
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
Server load: low (24%) [HD]