node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANIA_00556 | ANIA_03619 | Q5BFX4 | Q5B761 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Subunit of MRX complex (Eurofung). | 0.999 |
ANIA_00556 | ANIA_04279 | Q5BFX4 | C8V3Z7 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Cell-cycle checkpoint serine-threonine kinase (Eurofung). | 0.617 |
ANIA_00556 | ANIA_04324 | Q5BFX4 | C8V968 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Putative b-zip transcription factor (Eurofung). | 0.538 |
ANIA_00556 | ANIA_04632 | Q5BFX4 | Q5B498 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Cytoplasm to vacuole targeting Vps64, putative (AFU_orthologue AFUA_2G02420). | 0.457 |
ANIA_00556 | ANIA_04872 | Q5BFX4 | G5EB17 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Ubiquitin-like domain-containing protein. | 0.538 |
ANIA_00556 | ANIA_06908 | Q5BFX4 | C8V2Y7 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | FHA domain protein (AFU_orthologue AFUA_5G13560). | 0.452 |
ANIA_00556 | ANIA_07563 | Q5BFX4 | Q5AVW7 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Protein kinase (Eurofung). | 0.617 |
ANIA_00556 | ANIA_07686 | Q5BFX4 | Q5AVJ4 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | FHA domain protein (AFU_orthologue AFUA_2G01670). | 0.452 |
ANIA_00556 | esa1 | Q5BFX4 | C8VBH4 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] | 0.580 |
ANIA_00556 | htbA | Q5BFX4 | P23754 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.516 |
ANIA_00556 | tel1 | Q5BFX4 | Q5BHE2 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). | 0.982 |
ANIA_03619 | ANIA_00556 | Q5B761 | Q5BFX4 | Subunit of MRX complex (Eurofung). | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.999 |
ANIA_03619 | ANIA_04279 | Q5B761 | C8V3Z7 | Subunit of MRX complex (Eurofung). | Cell-cycle checkpoint serine-threonine kinase (Eurofung). | 0.539 |
ANIA_03619 | ANIA_04632 | Q5B761 | Q5B498 | Subunit of MRX complex (Eurofung). | Cytoplasm to vacuole targeting Vps64, putative (AFU_orthologue AFUA_2G02420). | 0.450 |
ANIA_03619 | ANIA_06908 | Q5B761 | C8V2Y7 | Subunit of MRX complex (Eurofung). | FHA domain protein (AFU_orthologue AFUA_5G13560). | 0.450 |
ANIA_03619 | ANIA_07563 | Q5B761 | Q5AVW7 | Subunit of MRX complex (Eurofung). | Protein kinase (Eurofung). | 0.539 |
ANIA_03619 | ANIA_07686 | Q5B761 | Q5AVJ4 | Subunit of MRX complex (Eurofung). | FHA domain protein (AFU_orthologue AFUA_2G01670). | 0.450 |
ANIA_03619 | esa1 | Q5B761 | C8VBH4 | Subunit of MRX complex (Eurofung). | Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] | 0.609 |
ANIA_03619 | htbA | Q5B761 | P23754 | Subunit of MRX complex (Eurofung). | Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.506 |
ANIA_03619 | tel1 | Q5B761 | Q5BHE2 | Subunit of MRX complex (Eurofung). | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). | 0.975 |